IRIS
PIERMATTEO, LORENZO
 Distribuzione geografica
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Continente #
NA - Nord America 5.246
AS - Asia 2.506
EU - Europa 1.871
SA - Sud America 465
Continente sconosciuto - Info sul continente non disponibili 390
OC - Oceania 83
AF - Africa 62
Totale 10.623
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Nazione #
US - Stati Uniti d'America 5.061
SG - Singapore 1.181
IT - Italia 738
CN - Cina 436
BR - Brasile 362
RU - Federazione Russa 303
VN - Vietnam 227
HK - Hong Kong 209
DE - Germania 150
BD - Bangladesh 142
GB - Regno Unito 116
JP - Giappone 103
CA - Canada 94
IE - Irlanda 91
FI - Finlandia 83
AU - Australia 76
SE - Svezia 75
IN - India 64
ES - Italia 63
FR - Francia 57
NL - Olanda 49
AR - Argentina 42
PL - Polonia 35
MX - Messico 34
AT - Austria 30
TR - Turchia 28
ID - Indonesia 24
CO - Colombia 20
JM - Giamaica 20
IQ - Iraq 16
CZ - Repubblica Ceca 15
ZA - Sudafrica 15
CR - Costa Rica 14
CH - Svizzera 13
EC - Ecuador 12
VE - Venezuela 12
EG - Egitto 10
NG - Nigeria 10
UA - Ucraina 10
LT - Lituania 8
PH - Filippine 8
PY - Paraguay 8
AE - Emirati Arabi Uniti 7
MY - Malesia 7
NZ - Nuova Zelanda 7
BE - Belgio 6
KR - Corea 6
PK - Pakistan 6
DZ - Algeria 5
HN - Honduras 5
IR - Iran 5
JO - Giordania 5
UZ - Uzbekistan 5
IL - Israele 4
MA - Marocco 4
PE - Perù 4
SK - Slovacchia (Repubblica Slovacca) 4
TN - Tunisia 4
BB - Barbados 3
BG - Bulgaria 3
CM - Camerun 3
DK - Danimarca 3
GT - Guatemala 3
KE - Kenya 3
KH - Cambogia 3
KZ - Kazakistan 3
PR - Porto Rico 3
PT - Portogallo 3
SA - Arabia Saudita 3
TT - Trinidad e Tobago 3
TW - Taiwan 3
AL - Albania 2
AZ - Azerbaigian 2
CL - Cile 2
EE - Estonia 2
GR - Grecia 2
HU - Ungheria 2
LV - Lettonia 2
NI - Nicaragua 2
OM - Oman 2
RO - Romania 2
SN - Senegal 2
SV - El Salvador 2
TH - Thailandia 2
UY - Uruguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
BH - Bahrain 1
BN - Brunei Darussalam 1
CG - Congo 1
CI - Costa d'Avorio 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GE - Georgia 1
GY - Guiana 1
IS - Islanda 1
LC - Santa Lucia 1
LK - Sri Lanka 1
MD - Moldavia 1
MT - Malta 1
Totale 10.230
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Città #
Singapore 710
San Jose 558
Wilmington 479
Ashburn 384
Houston 310
Rome 227
Hong Kong 206
Chandler 195
Council Bluffs 188
Beijing 165
New York 162
Los Angeles 139
Fairfield 138
Santa Clara 119
Tokyo 102
Ho Chi Minh City 79
The Dalles 74
Dublin 70
Dallas 66
Helsinki 65
Milan 64
Buffalo 58
Hanoi 55
Denver 54
Woodbridge 54
Munich 53
Seattle 44
Nuremberg 42
Cambridge 38
Orem 38
São Paulo 38
Chicago 37
Moscow 37
Ann Arbor 35
Montreal 32
Medford 31
La Veta 29
Melbourne 28
Naples 28
Sydney 28
London 27
Engelhard 25
Washington 25
Phoenix 24
Brooklyn 21
Chennai 21
Toronto 19
Warsaw 19
Lauterbourg 18
Mexico City 18
Atlanta 17
Frankfurt am Main 17
Poplar 17
Redondo Beach 17
Stockholm 17
Canberra 16
Madrid 16
North Bergen 16
Vienna 16
Genoa 15
Lappeenranta 15
Lawrence 15
San Francisco 15
Amsterdam 14
Jakarta 14
Palermo 14
Barcelona 13
Cedarhurst 13
Kingston 13
Manchester 13
St. George 13
Bari 12
Brasília 12
Paris 12
San Diego 12
San José 12
Creede 11
Johannesburg 11
Philadelphia 11
Haiphong 10
Boston 9
Florence 9
Las Vegas 9
Boardman 8
Brno 8
Chandigarh 8
Charlotte 8
Guangzhou 8
Mumbai 8
Padova 8
Palo Alto 8
Rio de Janeiro 8
Auckland 7
Belo Horizonte 7
Hải Dương 7
Pesaro 7
St Louis 7
Suzhou 7
Ankara 6
Biên Hòa 6
Totale 6.048
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Nome #
High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance 392
HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets 350
A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro 279
A snapshot of virological presentation and outcome of immunosuppression-driven HBV reactivation from real clinical practice: Evidence of a relevant risk of death and evolution from silent to chronic infection 272
Droplet digital PCR assay as an innovative and promising highly sensitive assay to unveil residual and cryptic HBV replication in peripheral compartment 225
Virological reactivation of hepatitis B virus is a frequent event in anti-HBc-positive/HBsAg-negative HIV-infected patients switching to Tenofovir-sparing therapy as revealed by highly-sensitive HBV assays. 221
Highly Sensitive HBsAg, Anti-HBc and Anti HBsAg Titres in Early Diagnosis of HBV Reactivation in Anti-HBc-Positive Onco-Haematological Patients 201
Cryptic HBV replicative activity is frequently revealed in anti-HBC-positive/hbsag-negative patients with HIV infection by highly sensitive molecular assays, and can be predicted by integrating classical and novel serological HBV markers 191
Quantification of intrahepatic total HBV DNA in liver biopsies of HBV-infected patients by a modified version of COBAS® Ampliprep/COBAS®TaqMan HBV test v2.0 187
Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection 181
Establishment of a Seronegative Occult Infection With an Active Hepatitis B Virus Reservoir Enriched of Vaccine Escape Mutations in a Vaccinated Infant After Liver Transplantation 175
Frequency of atypical mutations in the spike glycoprotein in SARS-CoV-2 circulating from July 2020 to July 2022 in central Italy: a refined analysis by Next Generation Sequencing 169
Long-term SARS-CoV-2 infection associated with viral dissemination in different body fluids Including bile in two patients with acute cholecystitis 166
In the setting of HIV-infection, HBV-reactivation is revealed by highly sensitive assays in a conspicuous fraction of anti-HBc-positive/HBsAg-negative patients switching to Tenofovir-sparing therapy. 161
HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015-21 157
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control 153
Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B 138
HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV Reactivation 138
New markers in monitoring the reactivation of hepatitis B virus infection in immunocompromised hosts 137
for the Icona Foundation Study Group Reactivation of hepatitis B virus is a frequent event in anti-HBc-positive/HBsAg-negative HIV-infected patients switching to Tenofovir sparing therapy as revealed by highly sensitive HBV assays. 129
Prevalence of hepatitis D virus infection in Central Italy has remained stable across the last 2 decades with dominance of subgenotypes 1 and characterized by elevated viral replication 124
HBcrAg tightly correlates with elevated HDV replicative activity and with enhanced liver inflammation and damage: role of HBcrAg as a biomarker of liver disease progression in the setting of HDV co-infection 123
Circulation of sars-cov-2 variants in central Italy: spike variability characterization by deep-sequencing. 117
Acquisition of positively charged amino acids in HBsAg C-terminus correlates with HBV-induced liver cancer, hampers HBsAg stability and secretion and promotes cell survival 117
SARS-CoV-2 variants and their relevant mutational profiles: update summer 2021 116
Utility of accessible SARS-CoV-2 specific immunoassays in vaccinated adults with a history of advanced HIV infection 114
Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies 110
Human monocyte-derived macrophages (MDM): model 1 (GM-CSF) 108
The acquisition of positively charged amino acids in HBsAg C-terminus correlates with HBV-induced liver cancer in vivo, impairs HBsAg secretion and affects its structural stability in vitro 107
HIV DNA viral reservoirs in blood and gut-associated lymphoid tissues (GALT): Implications of switch from triple antiretroviral therapy (ART) to 2-drug dolutegravir/lamivudine regimens 107
Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile 106
HIV/HBV coinfection remodels the immune landscape and natural killer cell ADCC functional responses 105
HUMAN ENDOGENOUS RETROVIRUSES EXPRESSION CORRELATES WITH HIV RESERVOIR, LYMPHOCYTES ACTIVATION AND LOW CD4 COUNT IN VIROLOGICALLY SUPPRESSED PATIENTS 104
HDV epidemic in Central Italy is stable over the last two decades and is characterized by the circulation of multiple HDV subgenotypes 1 inducing different inflammatory stimuli 103
An in-depth characterization of VOCs circulation by using NGS analysis of the Spike protein. 102
Novel concepts on mechanisms underlying Hepatitis Delta virus persistence and related pathogenesis 101
Kinetics of HBsAg forms in chronic hepatitis delta patients treated with bulevirtide for 48 weeks: correlation with virological response 100
An increase in the levels of middle surface antigen characterizes patients developing HBV-driven liver cancer despite prolonged virological suppression 100
HDV replicative activity parallels the production of the three HBsAg forms (Large, Middle and Small HBsAg) and its pathogenetic impact is exacerbated by concomitant HBV replication 99
Determinants of worse liver-related outcome according to HDV infection among HBsAg positive persons living with HIV: Data from the ICONA cohort 99
Hepatitis delta virus (HDV) infection : frequency and outcome in persons living with HIV (PLWH). Data from the ICONA (Italian cohort of naïve for antiretrovirals) cohort 99
The acquisition of positively charged amino acids in HBsAg C- terminus impairs HBsAg secretion, affects its structural stability and is associated with HBV-induced liver cancer 98
ULTRASENSITIVE HBV-RNA QUANTIFICATION AS A PROMISING BIOMARKER TO OPTIMIZE THE STAGING OF CHRONIC HBV INFECTION AND TO DETECT MINIMAL VIRAL ACTIVITY UNDER PROLONGED VIROLOGICAL SUPPRESSION AND OCCULT HBV INFECTION. 97
Higher levels of three HBsAg forms (Large, Middle and Small HBsAg) are associated with HDV replication and with the degree of disease and liver damage. 97
Impact of pre-existent drug resistance on virological efficacy of single tablet regimens in people living with HIV 95
Insights into the Currently Available Drugs and Investigational Compounds Against RSV with a Focus on Their Drug-Resistance Profiles 94
Stable temporal trend of HDV seroprevalence in central Italy across the last two decades with the circulation of HDV sub-genotypes 1 inducing different inflammatory stimuli 93
Ultrasensitive HBV-RNA quantification by droplet digital PCR is a promising biomarker to optimize the staging of chronic HBV infection and to identify minimal viral activity under prolonged virological suppression. 91
Kinetics of hepatitis B virus replication in anti-HBc positive/HBsAg-negative people with HIV switching to tenofovir sparing therapy 91
HDV INFECTION IS STABLE IN CENTRAL ITALY ACROSS THE LAST TWO DECADES AND IS CHARACTERIZED BY THE CIRCULATION OF MULTIPLE HDV SUB-GENOTYPES 1 WITH A DIFFERENT PRO-INFLAMMATORY POTENTIAL 90
Hepatitis B-related hepatic flare during immune reconstitution syndrome after antiretroviral treatment initiation in an HBV surface antigen-positive patient with HIV: viroimmunological and histological characterization 89
Chronic HDV coinfection (CHD) is characterized by a different HBsAg isoforms composition respect to HBV mono-infection with higher middle- and large-HBs levels paralleling the replicative and cytolytic activity of HDV. 89
A peculiar HBsAg isoforms composition characterizes chronic HDV coinfection respect to HBV mono-infection, with higher middle-/large-HBs levels paralleling HDV activity. 88
POTENT ANTIVIRAL ACTIVITY OF NEW GENERATION HIV-1 MATURATION INHIBITORS ON HUMAN PRIMARY CELLS 87
Heterogeneity in the diagnostic sensitivities of HDV RNA quantification assays used in clinical practice in Italy: data from the first national quality control multicenter study. 87
Evaluation of HIV-DNA and residual viremia levels through week 96 in HIV-infected individuals who continue a two-drug or switch to a three-drug integrase strand transfer inhibitor-based regimen 87
Evidence of extensive transcriptionally active HBV integrations involving genetic regions crucial for cell proliferation in the early phases of chronic infection even in the setting of limited liver damage 86
Neuro-Axonal Damage and Alteration of Blood–Brain Barrier Integrity in COVID-19 Patients 85
PREVALENCE AND OUTCOME OF HEPATITIS DELTA VIRUS (HDV) INFECTION AMONG PERSONS LIVING WITH HIV (PLWH) IN ITALY: THE DELTA-ICONA STUDY OC 150 81
Cryptic HBV activity is frequently observed among anti-HBc positive/HBsAg negative people living with HIV infection during HBV-active art and can jeopardize the full control of HIV replication. 81
The intrahepatic activity of Hepatitis Delta virus is sustained by an abundant production of HBs transcripts, mainly derived from integrated HBV-DNA, and is not strictly related to the extent of HBV reservoir 80
Total HIV DNA and cell-associated HIV RNA viral reservoirs in PBMCs and GALT in patients on triple-ART and switching to dual-ART regimens. 79
Heterogeneity in the diagnostic performances of HDV RNA quantification assays used in clinical practice in Italy: results from a national quality control multicenter study. 79
Kinetics of the Three HBsAg Isoforms along with HDV-RNA Predict Virological Response in CHD Patients Treated with Bulevirtide for 48 Weeks 77
Evidence of abundant transcriptionally active HBV-integration events involving genetic regions crucial for cell proliferation in the setting of HBeAg positive infection. 77
Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cure 76
Chronic HDV infection is sustained by an intense HBsAg production fromintegrated HBVDNA in the setting of a limited or even absent HBV reservoir. 76
THE ENRICHMENT OF POSITIVELY CHARGED AMINO ACIDS IN HBsAg C-TERMINUS IMPAIRS HBsAg SECRETION, AFFECTS ITS STRUCTURAL STABILITY AND IS CORRELATED WITH HBV-INDUCED LIVER CANCER. 76
PATHWAYS UNDERLYING HDV PERSISTENCE ACT INDEPENDENTLY FROM THE EXTENT OF HBV RESEVOIR AND ARE SUSTAINED BY AN ABUNDANT PRODUCTION OF HBSAG DERIVED FROM INTEGRATED HBV-DNA P 214 76
KINETICS OF THE THREE HBSAG ISOFORMS ALONG WITH HDV-RNA PREDICT VIROLOGICAL RESPONSE IN CHD PATIENTS TREATED WITH BULEVIRTIDE UP TO 96 WEEKS P 215 75
The transactivation of endogenous retroviruses correlates with HIV reservoir, lymphocytes activation and low CD4 count in virologically suppressed patients 74
Chronic HDV coinfection is characterized by a peculiar HBsAg isoforms composition respect to HBV mono-infection, with higher middle-/large-HBs levels paralleling HDV activity. 73
Different diagnostic performances of HDV RNA quantification assays used in clinical practicein Italy: results from a national quality control multicenter study. 71
Biological and clinical significance of classic and innovative virological parameters in the pathogenesis and in the clinical management of HBV infection 71
Evidence of extensive transcriptionally active HBV integrations involving genetic regions crucial for cell proliferation in the setting of HBeAg positive infection 70
The transactivation of human endogenous retroviruses is associated with HIV-1 reservoir, lymphocyte activation and low CD4 count in virologically suppressed PLWH 69
New insights into hepatitis B virus lymphotropism: implications for HBV-related lymphomagenesis 68
Kinetics of the three HBsAg forms along with HDV-RNA predict virological and biochemical responses in chronic hepatitis delta patients treated with bulevirtide for 48 weeks. 66
HDV persistence is sustained by HBsAg mainly derived from integrated HBV-DNA and is independent from the extent of HBV reservoir 66
HBsAg production from integrated HBV-DNA sustains HDV persistence in the setting of a limited or even absent HBV reservoir 65
Pathways sustaining HDV activity act independently from the size of HBV resevoir and are fueled by an abundant expression of HBsAg from integrated HBV-DNA 64
Total HIV-DNA quantification (automated Elitech InGenius platform) in antiretroviral treated people living with HIV: viro-immunological correlations 63
Serum HBsAg and highly-sensitive HBV-DNA quantification can predict HBsAg loss after nucleos(t)ide analogue systematic discontinuation in non cirrhotic patients with chronic hepatitis B 63
Comparison of diagnostic performances of HDV-RNA quantification assays used in clinical practice: Results from a national quality control multicenter study 61
HBs isoforms as innovative biomarkers in predicting virological response in chronic hepatitis delta patients treated with bulevirtide monotherapy. 59
The burden of HDV chronic infection and the gaps in HDV screening across Europe: an urgent need to strengthen diagnostic strategies at pan-European level 57
Transcriptionally active HBV integrations frequently occur in the early phases of chronic infection and mostly involve genetic regions crucial for cell proliferation. 55
Serum HBsAg and ddPCR HBV-DNA as predictive parameters of HBsAg loss after nucleo (s) tide analogue (NA) treatment discontinuation in non-cirrhotic patients with Chronic Hepatitis B 55
The composition of HBsAg along with HDV-RNA predicts virological response in chronic hepatitis delta patients treated with bulevirtide for 48 weeks. 54
HBs isoforms can play a role in predicting virological response in patients with chronic hepatitis delta under bulevirtide monotherapy. 50
Intrahepatic HDV Activity Is Fueled By Integrated HBV DNA-Derived HBs Independently From CccDNA Size 48
A high degree of genetic variability characterises HDV sub-genotypes 1 and can drive the selection of divergent genetic pathways modulating HDV replicative potential and cytolytic activity. 47
Chronic HDV coinfection is characterized by a more elevated production of all three HBsAg isoforms compared to HBV mono-infection, that parallels HDV replicative and cytolytic activity. 45
HDV persistence acts independently from HBV reservoir extent and is sustained by HBsAg production mainly derived from integrated HBV-DNA 43
Kinetics of occult hepatitis B infection in people with HIV switching from HBV-active ART to long-acting cabotegravir/rilpivirine 41
Despite a substantial burden of HDV infection, gaps in HDV screening still persists across Europe: an urgent need to strengthen diagnostic strategies at pan-European level 41
Clinical and laboratory parameters correlated to HDV undetectability after 48 weeks of bulevirtide 40
HDV sub-genotype 1 is characterized by increased genetic variability, which can promote the emergence of divergent genetic pathways that modulate HDV replicative potential and cytolytic activity. 37
Malagnino Valutazione della risposta biochimica e virologica dopo 72 settimane di terapia con Bulevirtide ed analisi della cinetica virale intraepatica in una coorte di pazienti affetti da epatite delta. 36
HBV integration can sustain intrahepatic HDV activity and can modulate HBV pathogenetic potential. 34
Totale 10.446
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Categoria #
all - tutte 44.397
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.397
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022231 0 0 0 16 9 26 25 17 86 8 1 43
2022/2023485 31 61 44 50 53 76 33 47 38 3 35 14
2023/2024726 138 16 74 49 73 80 38 11 25 134 24 64
2024/20251.952 70 358 227 143 88 159 212 103 200 127 133 132
2025/20264.471 456 171 400 433 439 177 506 533 530 384 247 195
2026/20271.616 299 272 759 286 0 0 0 0 0 0 0 0
Totale 10.623