La vulnerabilità nel settore energetico. Il quadro del diritto europeo e l’approccio dell’ordinamento italiano

Targeting Cancer Cell Energy Metabolism in Colorectal Cancer: Opportunities and Challenges from Drug Repositioning

Highlights: What are the main findings? Multiple repurposed drugs act on metabolic vulnerabilities of colorectal cancer (CRC), revealing untapped therapeutic potential beyond their original indications. These agents target key metabolic and signaling pathways (e.g., AMPK/mTOR, glycolysis) to suppress CRC growth and improve response to standard therapies. What are the implications of the main findings? Repositioning existing drugs provides a time- and cost-efficient route to accelerate therape...

Association between door-to-needle time and outcomes in acute ischemic stroke patients treated with intravenous thrombolysis plus mechanical thrombectomy: Analysis from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS)

Introduction: We aim to evaluate the association between door-to-needle time (DTN) and outcomes in a population of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) + mechanical thrombectomy (MT) in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS). Materials and methods: Patients with AIS secondary to middle cerebral artery or intracranial internal carotid artery occlusion with known times of symptoms onset, directly presenting to an MT-ca...

Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched analysis

Background: Dual antiplatelet therapy (DAPT) is a cornerstone of secondary prevention in patients with minor ischemic stroke or high-risk transient ischemic attack. The effectiveness and safety of DAPT may differ between patients with posterior (PCI) and anterior circulation infarct (ACI).Objectives: We aimed to compare short-term outcomes following DAPT between mild-to-moderate stroke patients with PCI versus ACI.Design: Propensity-matched analysis from a prospective real-world multicentric ...