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Hemofiltration for neuroprotection in acute ischemic stroke: A prospective, pilot study

Background: Hemofiltration reduces blood levels of cytokines, glutamate, and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients. Methods: A total of 37 patients (mean age 56 ± 16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n = 19) or standard treatment (n...

Extra corporeal membrane oxygenation in the critical trauma patient

Purpose of review The purpose of this review is to describe recent evidence regarding the use of extracorporeal membrane oxygenation (ECMO) as salvage therapy for severe cardiac or respiratory failure in patients with trauma. The characteristics of this cohort of patients, including the risk of bleeding and the need for systemic anticoagulation, are generally considered as relative contraindications to ECMO treatment. However, recent evidence suggests that the use of ECMO shou...

Hydroxyethyl starch and fluid resuscitation. Patient-oriented outcome is the “right way”

he intensive care unit (ICU) [1]. Fluid resuscitation is a relevant topic in critical care and the debate on optimal fluid management is evolving. Hydroxyethyl starch (HES) is a colloid used for volume replacement therapy with a controversial history: recently HES-derived products' market authorizations have been reevaluated and more restrictive rules have been released [2-5]. In the United States, the Food and Drug Administration has been requested to withdraw HES-based products by Publi...

Education in neuroanesthesia and neurocritical care: trends, challenges and advancements

Purpose of review We summarize the latest evidence in neuroanesthesia and neurocritical care (NCC) training. In addition, we describe the newer advancements that clinical educators face in these subspecialties. Lastly, we highlight educational approaches that may lead to an enhanced learning experience and development of necessary skills for neurosciences trainees. Recent findings Current neuroanesthesia and NCC training requires acquisition of specific skills for increasing complex surgical ...

Expanding Genetic and Clinical Spectra of Inherited Retinal Dystrophies: Identification of Three Novel PRPH2 Variants

Background/Objectives: Pathogenic variants in the PRPH2 gene are implicated in a wide spectrum of Inherited Retinal Dystrophies (IRDs), which show significant phenotypic heterogeneity. This study combines genomic, clinical, and instrumental data, including BCVA, OCT, ERG, and visual field testing, using a multimodal approach to identify known and novel PRPH2 variants, with the aim of refine genotype-phenotype correlations and improving the diagnosis of IRDs. Methods: A total of 830 Italian su...

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Prodotti recenti

Hemofiltration for neuroprotection in acute ischemic stroke: A prospective, pilot study

Extra corporeal membrane oxygenation in the critical trauma patient

Hydroxyethyl starch and fluid resuscitation. Patient-oriented outcome is the “right way”

Education in neuroanesthesia and neurocritical care: trends, challenges and advancements

Expanding Genetic and Clinical Spectra of Inherited Retinal Dystrophies: Identification of Three Novel PRPH2 Variants

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