Home page

Prodotti recenti

Histaminergic transmission slows progression of amyotrophic lateral sclerosis

Background Histamine is an immune modulator, neuroprotective, and remyelinating agent, beneficially acting on skeletal muscles and promoting anti-inflammatory features in amyotrophic lateral sclerosis (ALS) microglia. Drugs potentiating the endogenous release of histamine are in trial for neurological diseases, with a role not systematically investigated in ALS. Here, we examine histamine pathway associations in ALS patients and the efficacy of a histamine-mediated therapeutic strategy in ALS...

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

Amyotrophic lateral sclerosis (ALS) is a disease with a strong neuroinflammatory component sustained by activated microglia contributing to motoneuron death. However, how to successfully balance neuroprotective versus neurotoxic actions by the use of antinflammatory agents is still under scrutiny. We have recently shown that the antihistamine clemastine, an FDA-approved drug, can influence the M1/M2 switch occurring in SOD1-G93A ALS microglia.Here, we have chronically treated female SOD1-G93A...

Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis

Multiple sclerosis (MS) is characterized by macrophage accumulation and inflammatory infiltrates into the CNS contributing to demyelination. Because purinergic P2X7 receptor (P2X7R) is known to be abundantly expressed on cells of the hematopoietic lineage and of the nervous system, we further investigated its phenotypic expression in MS and experimental autoimmune encephalomyelitis conditions. By quantitative reverse transcription polymerase chain reaction and flow cytometry, we analyzed the ...

P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis

Muscle weakness plays an important role in neuromuscular disorders comprising amyotrophic lateral sclerosis (ALS). However, it is not established whether muscle denervation originates from the motor neurons, the muscles or more likely both. Previous studies have shown that the expression of the SOD1G93A mutation in skeletal muscles causes denervation of the neuromuscular junctions, inability to regenerate and consequent atrophy, all clear symptoms of ALS. In this work, we used SOD1G93A mice, ...

Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS

(1) Background: Amyotrophic lateral sclerosis (ALS) is a multifactorial non-cell autonomous disease where activation of microglia and astrocytes largely contributes to motor neurons death. Heat shock proteins have been demonstrated to promote neuronal survival and exert a strong anti-inflammatory action in glia. Having previously shown that the pharmacological increase of the histamine content in the central nervous system (CNS) of SOD1-G93A mice decreases neuroinflammation, reduces motor neu...

Ricerca

Aggiungi

Scopri

Prodotti più visti

COMPLICANZE DELLA CHIRURGIA LAPAROSCOPICA DEI LAPAROCELI E DELLE ERNIE VENTRALI: NOSTRA ESPERIENZA
Anatomia delle Brigate rosse. Le radici ideologiche del terrorismo rivoluzionario
IL TRATTAMENTO DEL PROLASSO RETTALE PER VIA PERINEALE
Ruolo del polimorfismo 4G/5G del gene PAI-1 nel determinismo degli eventi tromboembolici venosi
Alterazione della sottopopolazione linfocitaria endometriale in donne con sindrome dell’ovaio policistico e poliabortività
L'ordinario e il sublime : due saggi sulla cultura contemporanea
La transazione del condebitore solidale
The effects of the Covid-19 pandemic on Italian learning ecosystems: the school teachers’ perspective at the steady state
Appendice metrica ad Euripide. Le Baccanti
Impiego del triossido di arsenico nella leucemia acuta promielocitica in recidiva molecolare

Prodotti più scaricati

Nuova modellazione del comportamento delle cerniere plastiche nel c.a.
Fascismo, scuola e società in Sardegna: l'istruzione classica, scientifica e magistrale
Strutture cristallografiche di complessi tra l’Acetilcolinesterasi da Torpedo Californica e quattro nuovi inibitori, potenziali farmaci per l’Alzheimer
Uso dell'associazione Doxorubicina liposomiale pegilato-Vinblastina-Bleomicina-Dacarbazina nel trattamento dei linfomi cutanei in stadio avanzato
Erasmo da Rotterdam
Profili di diritto comunitario dell'ambiente
Modellazione ed analisi di strutture precompresse con cavi non aderenti
Analisi di stabilità di cavità scavate a modesta profondità in rocce tenere
Il Festival di Sanremo : parole e suoni raccontano la nazione
Il procedimento di risoluzione delle controversie riguardanti l'affidamento dei figli ovvero l'attribuzione dell'esercizio della potestà su di essi

Esplora il catalogo della ricerca

Benvenuti in ART - Anagrafe della Ricerca dell’Università degli studi di Roma "Tor Vergata"

Prodotti recenti

Histaminergic transmission slows progression of amyotrophic lateral sclerosis

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis

P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis

Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS

Help-desk

Creative commons

Sherpa/Politiche editoriali

Ricerca

Scopri

Tipologia

Appartenenza

Rivista

Serie

Data di pubblicazione

Settori ISICRUI

Prodotti più visti

Prodotti più scaricati

110.401

pubblicazioni

19.159

open-access

6.452.755

downloads

45.996

fulltext

8.835

autori