FoxO1 in mitochondria of adipose tissue: impact on cell response to nutrients availability

Chronic nutrient overload promotes adipose tissue expansion, shortens life span and accelerates the onset of age-related disorders. By contrast, dietary regimens such as nutrient restriction, delay or attenuate age-associated degenerative processes in a wide variety of organisms from yeast to primates. The response of an organism to nutrient restriction consists in transcriptional and metabolic adaptations with prominent changes in adipose tissue through enhanced lipid catabolism. Moreover, i...

Intermittent preventive treatment of congenital syphilis in pregnancy: a Ugandan pilot study

BACKGROUND: Syphilis is an ubiquitous chronic sexually transmitted disease characterized by intermittent active and dormant stages. It is estimated that 50-80 % of untreated syphilis acquired during pregnancy lead to congenital syphilis. Children born with congenital infection are more prone to paediatric diseases and maintain lifelong deficiencies compared to their healthy counterparts. Thus, prevention and early treatment of the mother is overwhelmingly considered the best approach in prote...

Stile dell’implicito: a partire dall’estetica di John Dewey

Concettualizzazione e sviluppo di un linguaggio standardizzato per la pratica ostetrica

Background: Per svolgere la loro attività professionale le ostetriche seguono il processo di Midwifery (Midwifery Care Process). Le prime fasi del processo di Midwifery si basano dalla capacità delle ostetriche di formulare un ragionamento diagnostico, ma ad oggi non esiste un una vera tassonomia che sottintenda il processo di valutazione ostetrico. Pertanto, il presente programma dottorale si è posto i seguenti obiettivi: (1) sintetizzare i bisogni delle donne al momento del parto; (2) valut...