The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood. We examined the intrahepatic HBV reservoir, the occurrence of HBV DNA integration and its impact on the hepatocyte transcriptome in hepatitis B 'e' antigen (HBeAg)-negative chronic hepatitis B (CHB).

Svicher, V., Salpini, R., Piermatteo, L., Carioti, L., Battisti, A., Colagrossi, L., et al. (2020). Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B. GUT, 70(12), 2337-2348 [10.1136/gutjnl-2020-323300].

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

Svicher, Valentina;Salpini, Romina;Piermatteo, Lorenzo;Battisti, Arianna;Colagrossi, Luna;Scutari, Rossana;Surdo, Matteo;Ceccherini Silberstein, Francesca;Perno, Carlo Federico;
2020-12-21

Abstract

The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood. We examined the intrahepatic HBV reservoir, the occurrence of HBV DNA integration and its impact on the hepatocyte transcriptome in hepatitis B 'e' antigen (HBeAg)-negative chronic hepatitis B (CHB).
21-dic-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
chronic viral hepatitis
hepatitis B
hepatocellular carcinoma
liver biopsy
hdl:2108/303917
Svicher, V., Salpini, R., Piermatteo, L., Carioti, L., Battisti, A., Colagrossi, L., et al. (2020). Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B. GUT, 70(12), 2337-2348 [10.1136/gutjnl-2020-323300].
Svicher, V; Salpini, R; Piermatteo, L; Carioti, L; Battisti, A; Colagrossi, L; Scutari, R; Surdo, M; Cacciafesta, V; Nuccitelli, A; Hansi, N; Ceccherini Silberstein, F; Perno, Cf; Gill, Us; Kennedy, Ptf
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/303917
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