Distribuzione geografica
Continente #
NA - Nord America 39.285
EU - Europa 6.073
AS - Asia 833
SA - Sud America 11
Continente sconosciuto - Info sul continente non disponibili 8
OC - Oceania 7
AF - Africa 4
Totale 46.221
Nazione #
US - Stati Uniti d'America 39.273
PL - Polonia 2.228
FR - Francia 1.011
IT - Italia 533
SE - Svezia 533
UA - Ucraina 489
IE - Irlanda 409
DE - Germania 406
KR - Corea 370
CN - Cina 363
GB - Regno Unito 190
FI - Finlandia 122
RU - Federazione Russa 61
BE - Belgio 37
NL - Olanda 17
HK - Hong Kong 13
SG - Singapore 13
IN - India 12
JP - Giappone 11
CA - Canada 9
CH - Svizzera 9
EU - Europa 7
RO - Romania 7
TR - Turchia 7
VN - Vietnam 7
ID - Indonesia 6
UZ - Uzbekistan 6
CL - Cile 5
ES - Italia 5
IL - Israele 5
IR - Iran 5
KG - Kirghizistan 5
BR - Brasile 4
CZ - Repubblica Ceca 4
NZ - Nuova Zelanda 4
AU - Australia 3
DZ - Algeria 3
HR - Croazia 3
MY - Malesia 3
SA - Arabia Saudita 3
AE - Emirati Arabi Uniti 2
AT - Austria 2
EC - Ecuador 2
GR - Grecia 2
MX - Messico 2
A2 - ???statistics.table.value.countryCode.A2??? 1
DK - Danimarca 1
DM - Dominica 1
EG - Egitto 1
LK - Sri Lanka 1
LU - Lussemburgo 1
MD - Moldavia 1
NO - Norvegia 1
PT - Portogallo 1
TH - Thailandia 1
Totale 46.221
Città #
Woodbridge 11.952
Wilmington 10.435
Houston 9.686
Kraków 2.219
Fairfield 1.204
Ann Arbor 905
Chandler 715
Ashburn 584
Seattle 465
Jacksonville 444
Cambridge 417
Dublin 389
New York 381
Dearborn 320
Medford 286
Rome 264
Beijing 145
Lawrence 133
Menlo Park 86
San Diego 79
Zhengzhou 49
Milan 46
Boardman 43
Daejeon 43
Norwalk 42
Mülheim 34
Brussels 32
Redwood City 30
Engelhard 27
Nanjing 26
London 24
Falls Church 22
Mountain View 22
Creede 21
Guangzhou 20
Kunming 17
Hefei 16
Palo Alto 16
Verona 16
Helsinki 15
Seoul 14
Shanghai 14
University Park 13
Seongnam 12
Phoenix 11
Los Angeles 10
Nanchang 10
Saint Petersburg 10
San Mateo 10
Naples 9
Toronto 9
Cedarhurst 8
Hong Kong 8
Chicago 7
Hangzhou 7
Hounslow 7
Prescot 7
San Francisco 7
Detroit 6
Fuzhou 6
Nürnberg 6
Portland 6
Redmond 6
Zurich 6
Kilburn 5
Nepi 5
Pomezia 5
Poznan 5
San Jose 5
Washington 5
Augusta 4
Chengdu 4
Council Bluffs 4
Fiuggi 4
Hebei 4
Istanbul 4
Marana 4
Tappahannock 4
Veroli 4
Waanrode 4
Bologna 3
Bolzano 3
Central 3
Dong Ket 3
Ercolano 3
Hanoi 3
Indiana 3
Kaliningrad 3
Kendall Park 3
Kuala Lumpur 3
Nanning 3
Palma De Mallorca 3
Paris 3
Rieti 3
Rimini 3
Riyadh 3
Santa Clara 3
Singapore 3
Southwark 3
Togliatti 3
Totale 42.009
Nome #
The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors 704
Oleuropein shows copper complexing properties and noxious effect on cultured SH-SY5Y neuroblastoma cells depending on cell copper content 503
DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family 489
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases 483
Functional modulation of the Thr72->Ile mutant from Scapharca inaequivalvis homodimeric hemoglobin 481
A natural anticancer agent thaspine targets human topoisomerase IB 469
Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation. 455
A Simple and Fast Semiautomatic Procedure for the Atomistic Modeling of Complex DNA Polyhedra 455
Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I 454
Structural-dynamical investigation of the ZnuA histidine-rich loop: involvement in zinc management and transport 453
SSADH deficiency in an Italian family: a novel ALDH5A1 gene mutation affecting the succinic semialdehyde substrate binding site. 452
The Essential Dynamics of Cu,Zn superoxide dismutase: Suggestion of intersubunit communication 450
Binding to DPF-motif by the POB1 EH domain is responsible for POB1-Eps15 interaction 449
Active site copper and zinc ions modulate the quaternary structure of prokaryotic Cu,Zn superoxide dismutase 448
Comparative simulative analysis of single and double stranded truncated octahedral DNA nanocages 446
The Salmonella enterica ZinT structure, zinc affinity and interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc 438
Simulative and experimental investigation on the cleavage site that generates the soluble human LOX-1 436
Mapping the copper ligands of Cu,Zn superoxide dismutase by nuclear Overhauser enhancement of the isotropically shifted 1H-NMR lines of the Cu,Co derivative 435
High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase 435
Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity. 434
Effect of temperature and hydration on protein fluctuations: molecular dynamics simulation of Cu, Zn superoxide dismutase at six different temperatures. Comparison with neutron scattering data 433
Structural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studies 432
Simulative and experimental characterization of a pH-dependent clamp-like DNA triple-helix nanoswitch 431
Thermophilicity of wild type and mutant cold shock proteins by molecular dynamics simulation. 430
Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter 429
Structure and stability of the insulin dimer investigated by molecular dynamics simulation 428
Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin. 427
Substrate-induced conformational changes of the mitochondrial oxoglutarate carrier: A spectroscopic and molecular modelling study 427
Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking 427
Multiple molecular dynamics simulations of human LOX-1 and Trp150Ala mutant reveal the structural determinants causing the full deactivation of the receptor 427
Molecular dynamics simulations of the Trp repressor–DNA complex and the AV77 mutant 426
Structural insights into the multi-determinant aggregation of TDP-43 in motor neuron-like cells 426
A model for the incorporation of the metal from the copper chaperone CCS to Cu,Zn superoxide dismutase 422
Effect of Lys->Arg mutation on the thermal stability of Cu,Zn superoxide dismutase: Influence on the monomer-dimer equilibrium 419
Evolutionary conservativeness of electric field in the Cu,Zn superoxide dismutase active site. Evidence for coordinated mutations of charged aminoacid residues 419
Molecular mechanism of statin-mediated LOX-1 inhibition 418
Dimer Asymmetry in Superoxide Dismutase studied by Molecular Dynamics Simulation 418
Design of a novel LOX-1 receptor antagonist mimicking the natural substrate 416
Virtual Screening for the Development of Dual-Inhibitors Targeting Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1 416
Experimental and simulative dissociation of dimeric Cu,Zn superoxide dismutase doubly mutated at the intersubunit surface. 414
Molecular dynamics simulation of the antimicrobial salivary peptide histatin-5 in water and in trifluoroethanol 414
Role of the helix capping in the stability of the mouse prion (180-213) segment: investigation through molecular dynamics simulations 414
Access of anions and electrostatic interactions in the active site of Cu,Zn superoxide dismutase. 413
A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils 412
Structure of nano-Scale Truncated Octahedral DNA Cages: Variation of Single-stranded Linker Regions and Influence on Assembly Yields. 410
Is the activity-linked electrostatic gradient of bovine Cu/Zn superoxide dismutase conserved in homologous enzymes irrespective of the number and distribution of charges? 410
Molecular dynamics simulations of Cu,Zn superoxide dismutase: effect of temperature on dimer asymmetry 409
MD simulations of papillomavirus DNA-E2 protein complexes hints at a protein structural code for DNA deformation. 408
BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses 407
Influence of the single-strand linker composition on the structural/dynamical properties of a truncated octahedral DNA nano-cage family 407
Spectroscopic and molecular dynamics simulation studies of the interaction of insulin with glucose 407
Cu,Zn superoxide dismutase in prokaryotes and eukaryotes. 405
Structure solution and molecular dynamics refinement of the yeast Cu,Zn enzyme superoxide dismutase 405
Crystallographic characterization and three-dimensional model of yeast Cu,Zn superoxide dismutase 404
ADP/ATP mitochondrial carrier MD simulations to shed light on the structural–dynamical events that, after an additional mutation, restore the function in a pathological single mutant 402
Simulative Analysis of a Truncated Octahedral DNA Nanocage Family Indicates the Single-Stranded Thymidine Linkers as the Major Player for the Conformational Variability 402
Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function 402
Superoxide Dismutase Kinetics 400
Superefficient Enzymes 398
Molecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant. 397
Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient 397
Crystal structure solution and refinement of the semisynthetic cobalt -substituted bovine erythrocyte superoxide dismutase at 2.0Å resolution 396
Decoding the conformation-linked functional properties of nucleic acids by the use of computational tools 395
Receptor-Mediated Entry of Pristine Octahedral DNA Nanocages in Mammalian Cells 395
Effect of the charge distribution along the “ferritin-like” pores of Dps proteins on the iron incorporation process. 394
Molecular Dynamics Simulation of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha: evidence of a dynamical relationship between helices 3 and 5. 391
Static and dynamic water molecules in Cu,Zn superoxide dismutase 391
Effective binding force calculation in a dimeric protein by molecular dynamics simulation 389
Role of the electrostatic loop of Cu,Zn superoxide dismutase in the copper uptake process 388
Single mutation at the intersubunit interface confers extra efficiency to Cu,Zn superoxide dismutase 387
An electrostatic enzyme-substrate recognition: the case of Cu,Zn superoxide dismutase 387
Calculation of local electric fields in Shark Cu,Zn superoxide dismutase 386
Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB 382
Molecular modelling and electrostatic potential calculations on chemically modified Cu,Zn superoxide dismutases from Bos taurus and the shark Prionace glauca 381
Electrostatic recognition in redox copper proteins: a 1H NMR study of the protonation behavior of His 19 in oxidized and reduced Cu,Zn superoxide dismutase 376
Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor 376
Zinc ion coordination as a modulating factor of the ZnuA histidine-rich loop flexibility: a molecular modeling and fluorescence spectroscopy study 376
Screening of EDA1 gene in X-linked anhidrotic ectodermal dysplasia using DHPLC: identification of 14 novel mutations in Italian patients 375
Protein flexibility in monomeric Cu,Zn superoxide dismutase detected by molecular dynamics simulation and limited proteolysis 375
Deciphering the Structural Properties That Confer Stability to a DNA Nanocage. 374
Dynamics-function correlation in Photobacterium leiognathi Cu,Zn superoxide dismutase: a spectroscopic and molecular dynamics simulation study 374
A molecular dynamics simulation study decodes the early stage of the disassembly process abolishing the human SAMHD1 function 374
Carbon monoxide binding to the heme group at the dimeric interface modulates structure and copper accessibility in the Cu,Zn superoxide dismutase from Haemophilus ducreyi: in silico and in vitro evidences. 370
Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90 370
Structural and Dynamic Properties of the Homodimeric Hemoglobin from Scapharca inaequivalvis Thr72->Ile Mutant: A molecular dynamics simulation, low temperature visible absorption spectroscopy and resonance Raman spectroscopy studies 363
Conservation of local electric fields in the evolution of Cu,Zn superoxide dismutase 363
Conserved enzyme-substrate electrostatic attraction in prokariotic Cu,Zn superoxide dismutases 361
Peculiar spectroscopic and kinetic properties of Cys 47 in human placental glutathione transferase. Evidence for an atypical thiolate ion-pair near the active site 361
Modelling the three-dimensional structure and electrostatic potential field of the two Cu,Zn superoxide dismutase variants from Xenopus laevis 361
Evolutionary constraints for dimer formation in prokariotic Cu,Zn superoxide dismutase 360
Polymorphism in mitochondrial coding regions of mediterranean loggerhead turtles: Evolutionary relevance and structural effects 360
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. 356
NMR structure of the p63 SAM domain and dynamical properties of G534V and T537P pathological mutants, identified in the AEC syndrome 355
Intrinsic Dynamics Analysis of a DNA Octahedron by Elastic Network Model 354
Molecular dynamics simulation of solvated azurin: influence of surface solvent accessibility on water residence times 353
A spectroscopic and molecular dynamics study of native and of a mutant of Xenopus laevis Cu,Zn superoxide dismutase: mechanistic consequences of replacing four charged aminoacids on the electrostatic loop 353
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 350
Temperature-controlled encapsulation and release of an active enzyme in the cavity of a self-assembled DNA nanocage 348
Prokaryotic Cu/Zn Superoxide Dismutases 347
The bacterial high affinity Zn-uptake system: a possible target for novel antibiotics 344
Totale 40.868
Categoria #
all - tutte 80.008
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.008

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20193.344 0 0 0 0 0 0 0 0 0 1.061 1.197 1.086
2019/202011.616 1.045 866 810 1.083 962 1.257 1.068 1.060 1.010 919 747 789
2020/20216.534 742 708 781 833 676 674 768 645 171 188 258 90
2021/20221.793 124 191 262 106 40 82 103 67 174 105 131 408
2022/20231.981 198 174 61 238 182 447 197 114 196 4 112 58
2023/2024911 92 22 71 48 74 435 83 37 28 21 0 0
Totale 46.804