Under conditions of Zn(II) deficiency, the most relevant high affinity Zn(II) transport system synthesized by many Gram-negative bacteria is the ZnuABC transporter. ZnuABC is absent in eukaryotes and plays an important role in bacterial virulence. Consequently, ZnuA, the periplasmic component of the transporter, appeared as a good target candidate to find new compounds able to contrast bacterial growth by interfering with Zn(II) uptake.

Ilari, A., Pescatori, L., Di Santo, R., Battistoni, A., Ammendola, S., Falconi, M., et al. (2015). Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter. BIOCHIMICA ET BIOPHYSICA ACTA, 1860(3), 534-541 [10.1016/j.bbagen.2015.12.006].

Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter

Battistoni A;Ammendola S;Falconi M;
2015-12-12

Abstract

Under conditions of Zn(II) deficiency, the most relevant high affinity Zn(II) transport system synthesized by many Gram-negative bacteria is the ZnuABC transporter. ZnuABC is absent in eukaryotes and plays an important role in bacterial virulence. Consequently, ZnuA, the periplasmic component of the transporter, appeared as a good target candidate to find new compounds able to contrast bacterial growth by interfering with Zn(II) uptake.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11
eng
Lead compounds; Salmonella enterica; X-ray structure; ZnuA; ZnuABC zinc transporter
Ilari, A., Pescatori, L., Di Santo, R., Battistoni, A., Ammendola, S., Falconi, M., et al. (2015). Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter. BIOCHIMICA ET BIOPHYSICA ACTA, 1860(3), 534-541 [10.1016/j.bbagen.2015.12.006].
Ilari, A; Pescatori, L; Di Santo, R; Battistoni, A; Ammendola, S; Falconi, M; Berlutti, F; Valenti, P; Chiancone, E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/133869
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