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EnglishAn entirely double stranded truncated octahedral DNA nanocage structure has been modeled in silico and the molecular dynamics simulation technique has been used to characterize its dynamical properties. In this polyhedron, unlike other previously simulated truncated octahedral cages, the linker regions are represented by double helices. Simulations of nanocages, with single or double stranded linkers, have been carried out to evaluate differences in their dynamic behavior. The results indicate a higher rigidity of the double stranded nanocage in comparison with the structure sharing the same geometry but having single stranded linkers. In detail the highly constrained geometry of the entirely double stranded DNA cage generates a distortion of the polyhedron and a fixed orientation of the double helices that results in constant exposure of selected bases on the cage external surface. These bases may represent the preferential sites for chemical modifications endowing the structure with specific molecular recognition capabilities.
Iacovelli, F., Falconi, M., Knudsen, B.r., & Desideri, A. (2016). Comparative simulative analysis of single and double stranded truncated octahedral DNA nanocages. RSC ADVANCES, 6(42), 35160-35166 [10.1039/c5ra27591a].
| Tipologia: | Articolo su rivista | |
| Citazione: | Iacovelli, F., Falconi, M., Knudsen, B.r., & Desideri, A. (2016). Comparative simulative analysis of single and double stranded truncated octahedral DNA nanocages. RSC ADVANCES, 6(42), 35160-35166 [10.1039/c5ra27591a]. | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore BIO/11 | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c5ra27591a | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 2016 | |
| Titolo: | Comparative simulative analysis of single and double stranded truncated octahedral DNA nanocages | |
| Autori: | ||
| Autori: | Iacovelli, F; Falconi, M; Knudsen, Br; Desideri, A | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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|---|---|---|---|---|
| 98.Iacovelli_RSC_Advances_16.pdf | N/A | Copyright dell'editore | UNIVERSITY_NETWORK Richiedi una copia |
http://hdl.handle.net/2108/144527
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