IRIS
CACCURI, ANNA MARIA
 Distribuzione geografica
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Continente #
NA - Nord America 31.881
EU - Europa 3.546
AS - Asia 3.517
SA - Sud America 496
AF - Africa 52
OC - Oceania 30
Continente sconosciuto - Info sul continente non disponibili 9
Totale 39.531
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Nazione #
US - Stati Uniti d'America 31.782
SG - Singapore 1.744
CN - Cina 744
PL - Polonia 543
BR - Brasile 440
RU - Federazione Russa 438
UA - Ucraina 427
FR - Francia 412
DE - Germania 395
IT - Italia 380
VN - Vietnam 329
IE - Irlanda 303
HK - Hong Kong 253
GB - Regno Unito 182
SE - Svezia 178
FI - Finlandia 148
KR - Corea 99
JP - Giappone 83
IN - India 57
CA - Canada 48
ID - Indonesia 37
BD - Bangladesh 34
MX - Messico 33
NL - Olanda 30
CZ - Repubblica Ceca 28
AU - Australia 27
AR - Argentina 21
TR - Turchia 21
UZ - Uzbekistan 21
IQ - Iraq 19
BE - Belgio 18
ZA - Sudafrica 18
ES - Italia 13
PH - Filippine 13
AT - Austria 12
MY - Malesia 10
CO - Colombia 9
SA - Arabia Saudita 7
DZ - Algeria 6
EU - Europa 6
KG - Kirghizistan 6
LT - Lituania 6
VE - Venezuela 6
EC - Ecuador 5
IL - Israele 5
JM - Giamaica 5
PK - Pakistan 5
PY - Paraguay 5
TH - Thailandia 5
TN - Tunisia 5
CL - Cile 4
MA - Marocco 4
TT - Trinidad e Tobago 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
BG - Bulgaria 3
CH - Svizzera 3
DO - Repubblica Dominicana 3
EG - Egitto 3
ET - Etiopia 3
HU - Ungheria 3
IR - Iran 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PE - Perù 3
SI - Slovenia 3
SN - Senegal 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
BO - Bolivia 2
CR - Costa Rica 2
GR - Grecia 2
HN - Honduras 2
KE - Kenya 2
KZ - Kazakistan 2
NP - Nepal 2
PT - Portogallo 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
A1 - Anonimo 1
AM - Armenia 1
BB - Barbados 1
BH - Bahrain 1
BW - Botswana 1
BY - Bielorussia 1
CY - Cipro 1
DK - Danimarca 1
GI - Gibilterra 1
HR - Croazia 1
JO - Giordania 1
KW - Kuwait 1
LB - Libano 1
LK - Sri Lanka 1
LY - Libia 1
MD - Moldavia 1
MK - Macedonia 1
MM - Myanmar 1
Totale 39.523
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Città #
Woodbridge 9.225
Wilmington 7.764
Houston 7.462
Singapore 972
Fairfield 962
Ann Arbor 793
Ashburn 610
Kraków 519
Chandler 447
Seattle 385
Jacksonville 369
San Jose 353
Cambridge 306
Dublin 283
Dearborn 267
Beijing 252
Hong Kong 246
New York 226
Medford 213
Rome 175
The Dalles 152
Santa Clara 132
Ho Chi Minh City 108
Council Bluffs 105
Lawrence 102
Los Angeles 98
Dallas 97
Zhengzhou 89
Moscow 73
Mülheim 73
Tokyo 73
Hanoi 67
Lauterbourg 65
San Diego 60
Buffalo 52
Helsinki 52
São Paulo 51
Menlo Park 48
Munich 41
Boardman 32
Orem 31
Milan 30
Jakarta 27
London 27
Hefei 26
Brno 23
Falls Church 23
Phoenix 23
Rio de Janeiro 23
Shanghai 23
Chicago 22
Del Norte 22
Guangzhou 21
Warsaw 20
Nuremberg 18
University Park 18
Mountain View 17
North Bergen 17
Toronto 17
Haiphong 16
Hangzhou 16
Nanjing 16
San Francisco 16
Atlanta 15
Chennai 15
Brussels 14
Da Nang 14
Mexico City 13
Norwalk 13
San Mateo 13
Brooklyn 12
Montreal 12
Poplar 12
Redondo Beach 12
Amsterdam 11
Querétaro 11
Redwood City 11
Turku 11
Kunming 10
Melbourne 10
Seoul 10
Stockholm 10
Columbus 9
Jinan 9
Johannesburg 9
Manchester 9
Mumbai 9
Palo Alto 9
Tashkent 9
Baghdad 8
Brasília 8
Chongqing 8
Denver 8
Frankfurt am Main 8
Tappahannock 8
Belo Horizonte 7
Boston 7
Chengdu 7
Nanchang 7
Ankara 6
Totale 34.265
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Nome #
Proapoptotic activity of new glutathione S-transferase inhibitors 562
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases 554
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells 550
Colorimetric and fluorometric assays of glutathione transferase based on 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 534
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer 532
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines 525
The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex 500
TNFR-Associated Factor-2 (TRAF2): Not only a Trimer 492
Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1 488
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells: a protection mechanism against excess nitric oxide. 483
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 480
Solution structure of glutathione bound to human glutathione transferase P1-1: Comparison of NMR measurements with the crystal structure 477
Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1 477
A novel water-soluble nitrobenzoxadiazole is highly effective against vemurafenib-resistant human melanoma cells 472
Binding and kinetic mechanisms of the zeta class glutathione transferase 471
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione s-transferases investigation of ser-9 and tyr-113 in a glutathione s-transferase from the australian sheep blowfly, lucilia cuprina 469
The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate 469
Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. 468
Acidic glutathione transferase from human heart: characterization and N-terminal sequence determination 468
Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy 467
Temperature adaptation of glutathione S-transferase P1-1: a case for homotropic regulation of substrate binding 467
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents 465
In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma 464
Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum 461
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells. 460
Aggregation of pyrene-labeled microsomal glutathione S-transferase: effect of concentration 460
Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences 460
Use of 7-nitro-2,1,3 benzoxadiazole derivatives for anticancer therapy 458
The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. 456
Novel Glutathione S-Transferase Inhibitor Enhances Temozolomide Efficacy Against Malignant Melanoma 52nd Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies 450
S- aminoethyl- l -cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brain 449
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme 449
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 447
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome 445
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 444
Interaction of hemin with placental glutathione transferase 444
Superefficient Enzymes 443
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma 442
Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process 441
Inhibition of glutathione transferase pi from human placenta by 1-chloro-2,4-dinitrobenzene occurs because of covalent reaction with cysteine 47 441
Role of glutathione transferases in the mechanism of brostallicin activation. 436
Are the steady state kinetics of glutathione transferase always dependent on the deprotonation of the bound glutathione? New insights in the kinetic mechanism of GST P 1-1 431
Interaction between 1,4-thiazine derivatives and D-amino-acid oxidase 430
Glutathione S-transferase P1-1 as a target for mesothelioma treatment 430
Structural flexibility modulates the activity of human glutathione transferase P1-1: role of helix 2 flexibility in the catalytic mechanism 426
Intrinsic fluorescence quenching of glutathione transferase pi by glutathione binding 425
Detection of glutathione transferase activity on polyacrylamide gels 425
Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae) 424
Purification and characterization of a ketimine-reducing enzyme 422
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases 421
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 420
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. 415
Dissociation and unfolding of Pi-class glutathione transferase: evidence for a monomeric inactive intermediate 415
New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains 413
Investigation of the active site of human placenta glutathione transferase pi by means of a spin-labelled glutathione analogue 412
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 409
Glutathione-related enzyme activities in testis of patients with malignant diseases 408
N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases 408
Evolutionary strategy for optimization of GSH binding and catalysis in Alpha, Pi, Mu and theta glutathione transferases 406
Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart 406
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases 405
Redox forms of human placenta glutathione transferase 405
New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1 404
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases 402
Glutathione transferases and development of new principles to overcome drug resistance 400
Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells 397
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. 395
Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation 390
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme 389
Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems. 389
Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase 387
Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues 383
Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers 377
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases - Mechanism of action of potential anticancer drugs 376
Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases 367
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione 365
null 361
Inhibition of human placenta glutathione transferase P1-1 by calvatic acid 359
Ketimine rings: useful detectors of enzymatic activities in solution and on polyacrylamide gel: detection of L-amino acid oxidase, glutamine transaminase, pantetheinase, and acylase I 354
Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy 341
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase 335
Inhibition of human placenta glutathione transferase P1-1 by the antibiotic calvatic acid and its diazocyanide analogue--evidence for multiple catalytic intermediates 298
Study on the interaction between the skin detoxifying enzyme glutathione S-transferase and the substances listed in the CE/39/2000 rules with the "skin" annotation, finalized to the biological monitoring of exposed subjects 298
Studying the TRAF2 binding to model membranes: The role of subunits dissociation. 296
The glutathione s-transferase inhibitor 6-(7-Nitro-2,1,3-BenzoxaDiazol-4-ylthio)Hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma. 295
Activation of retinal Müller cells in response to glucose variability 282
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 277
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells 249
Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function 243
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 209
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione 182
Non-symmetrical structural behavior of a symmetric protein: the case of homo-trimeric TRAF2 (tumor necrosis factor-receptor associated factor 2) 174
Thiol-activated anticancer agents: The state of the art 167
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 123
High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells 119
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose 116
Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1 106
Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells 101
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 97
The odd faces of oligomers: The case of traf2-c, a trimeric c-terminal domain of tnf receptor-associated factor 88
Totale 39.067
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Categoria #
all - tutte 87.125
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 87.125
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021412 0 0 0 0 0 0 0 0 0 131 191 90
2021/20221.160 25 142 64 51 38 72 70 50 169 87 101 291
2022/20231.280 139 108 19 165 104 300 119 58 102 3 113 50
2023/2024658 65 18 16 17 40 211 62 36 56 10 6 121
2024/20252.419 114 480 280 133 64 158 150 129 214 163 307 227
2025/20263.984 344 207 515 329 424 159 601 504 499 402 0 0
Totale 39.785