IRIS
CACCURI, ANNA MARIA
 Distribuzione geografica
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Continente #
NA - Nord America 32.130
AS - Asia 3.639
EU - Europa 3.620
SA - Sud America 497
AF - Africa 52
OC - Oceania 30
Continente sconosciuto - Info sul continente non disponibili 9
Totale 39.977
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Nazione #
US - Stati Uniti d'America 32.015
SG - Singapore 1.760
CN - Cina 772
PL - Polonia 543
IT - Italia 445
BR - Brasile 441
RU - Federazione Russa 438
UA - Ucraina 427
FR - Francia 413
DE - Germania 398
VN - Vietnam 331
IE - Irlanda 303
HK - Hong Kong 256
GB - Regno Unito 183
SE - Svezia 178
FI - Finlandia 148
BD - Bangladesh 99
KR - Corea 99
JP - Giappone 86
IN - India 57
CA - Canada 53
ID - Indonesia 37
MX - Messico 34
NL - Olanda 31
CZ - Repubblica Ceca 28
AU - Australia 27
AR - Argentina 21
TR - Turchia 21
UZ - Uzbekistan 21
IQ - Iraq 19
BE - Belgio 18
ZA - Sudafrica 18
ES - Italia 16
PH - Filippine 13
AT - Austria 12
MY - Malesia 11
CO - Colombia 9
JM - Giamaica 8
SA - Arabia Saudita 7
DZ - Algeria 6
EU - Europa 6
KG - Kirghizistan 6
LT - Lituania 6
VE - Venezuela 6
AE - Emirati Arabi Uniti 5
EC - Ecuador 5
IL - Israele 5
PK - Pakistan 5
PY - Paraguay 5
TH - Thailandia 5
TN - Tunisia 5
CL - Cile 4
CR - Costa Rica 4
MA - Marocco 4
NP - Nepal 4
TT - Trinidad e Tobago 4
AL - Albania 3
BG - Bulgaria 3
CH - Svizzera 3
DO - Repubblica Dominicana 3
EG - Egitto 3
ET - Etiopia 3
HU - Ungheria 3
IR - Iran 3
NG - Nigeria 3
NI - Nicaragua 3
NZ - Nuova Zelanda 3
PE - Perù 3
SI - Slovenia 3
SN - Senegal 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BO - Bolivia 2
GR - Grecia 2
HN - Honduras 2
KE - Kenya 2
KZ - Kazakistan 2
PT - Portogallo 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
A1 - Anonimo 1
AM - Armenia 1
AW - Aruba 1
BH - Bahrain 1
BW - Botswana 1
BY - Bielorussia 1
CY - Cipro 1
DK - Danimarca 1
GI - Gibilterra 1
HR - Croazia 1
JO - Giordania 1
KW - Kuwait 1
LB - Libano 1
LK - Sri Lanka 1
LY - Libia 1
MD - Moldavia 1
Totale 39.967
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Città #
Woodbridge 9.225
Wilmington 7.764
Houston 7.465
Singapore 976
Fairfield 962
Ann Arbor 793
Ashburn 631
Kraków 519
Chandler 447
Seattle 387
San Jose 378
Jacksonville 369
Cambridge 306
Dublin 283
Dearborn 267
Beijing 254
Hong Kong 249
New York 238
Medford 213
Rome 186
The Dalles 152
Santa Clara 139
Council Bluffs 138
Ho Chi Minh City 109
Los Angeles 104
Lawrence 102
Dallas 97
Zhengzhou 89
Tokyo 74
Moscow 73
Mülheim 73
Hanoi 67
Lauterbourg 65
San Diego 61
Buffalo 55
Helsinki 52
São Paulo 51
Menlo Park 48
Munich 41
Boardman 32
Milan 32
Orem 31
Hefei 27
Jakarta 27
London 27
Brno 23
Chicago 23
Falls Church 23
Phoenix 23
Rio de Janeiro 23
Shanghai 23
Del Norte 22
Guangzhou 21
Warsaw 20
Nuremberg 18
Toronto 18
University Park 18
Mountain View 17
North Bergen 17
San Francisco 17
Haiphong 16
Hangzhou 16
Nanjing 16
Atlanta 15
Chennai 15
Brooklyn 14
Brussels 14
Da Nang 14
Montreal 14
Mexico City 13
Norwalk 13
San Mateo 13
Columbus 12
Poplar 12
Redondo Beach 12
Amsterdam 11
Querétaro 11
Redwood City 11
Turku 11
Kunming 10
Manchester 10
Melbourne 10
Seoul 10
Stockholm 10
Denver 9
Jinan 9
Johannesburg 9
Mumbai 9
Palo Alto 9
Tashkent 9
Baghdad 8
Brasília 8
Chongqing 8
Frankfurt am Main 8
Tappahannock 8
Belo Horizonte 7
Boston 7
Chengdu 7
Nanchang 7
Ankara 6
Totale 34.415
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Nome #
Proapoptotic activity of new glutathione S-transferase inhibitors 570
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells 560
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases 556
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer 541
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines 538
Colorimetric and fluorometric assays of glutathione transferase based on 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 534
The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex 513
TNFR-Associated Factor-2 (TRAF2): Not only a Trimer 497
Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1 492
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells: a protection mechanism against excess nitric oxide. 487
Solution structure of glutathione bound to human glutathione transferase P1-1: Comparison of NMR measurements with the crystal structure 482
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents 482
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 481
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione s-transferases investigation of ser-9 and tyr-113 in a glutathione s-transferase from the australian sheep blowfly, lucilia cuprina 479
Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1 477
A novel water-soluble nitrobenzoxadiazole is highly effective against vemurafenib-resistant human melanoma cells 477
Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy 476
Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum 473
Aggregation of pyrene-labeled microsomal glutathione S-transferase: effect of concentration 473
In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma 473
Binding and kinetic mechanisms of the zeta class glutathione transferase 471
Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. 471
Temperature adaptation of glutathione S-transferase P1-1: a case for homotropic regulation of substrate binding 470
The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate 469
Acidic glutathione transferase from human heart: characterization and N-terminal sequence determination 469
Use of 7-nitro-2,1,3 benzoxadiazole derivatives for anticancer therapy 463
Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences 462
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells. 461
The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. 457
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme 454
Novel Glutathione S-Transferase Inhibitor Enhances Temozolomide Efficacy Against Malignant Melanoma 52nd Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies 453
S- aminoethyl- l -cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brain 450
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome 449
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 447
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma 447
Interaction of hemin with placental glutathione transferase 447
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 444
Inhibition of glutathione transferase pi from human placenta by 1-chloro-2,4-dinitrobenzene occurs because of covalent reaction with cysteine 47 444
Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process 443
Superefficient Enzymes 443
Role of glutathione transferases in the mechanism of brostallicin activation. 442
Glutathione S-transferase P1-1 as a target for mesothelioma treatment 437
Are the steady state kinetics of glutathione transferase always dependent on the deprotonation of the bound glutathione? New insights in the kinetic mechanism of GST P 1-1 434
Interaction between 1,4-thiazine derivatives and D-amino-acid oxidase 432
Intrinsic fluorescence quenching of glutathione transferase pi by glutathione binding 428
Structural flexibility modulates the activity of human glutathione transferase P1-1: role of helix 2 flexibility in the catalytic mechanism 427
Purification and characterization of a ketimine-reducing enzyme 427
Detection of glutathione transferase activity on polyacrylamide gels 427
Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae) 425
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 425
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases 422
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. 422
Investigation of the active site of human placenta glutathione transferase pi by means of a spin-labelled glutathione analogue 417
Dissociation and unfolding of Pi-class glutathione transferase: evidence for a monomeric inactive intermediate 417
New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains 416
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 414
Evolutionary strategy for optimization of GSH binding and catalysis in Alpha, Pi, Mu and theta glutathione transferases 412
Glutathione-related enzyme activities in testis of patients with malignant diseases 410
N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases 410
Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells 410
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases 409
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases 408
Redox forms of human placenta glutathione transferase 408
Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart 406
New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1 405
Glutathione transferases and development of new principles to overcome drug resistance 402
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme 401
Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems. 399
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. 398
Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation 392
Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase 390
Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues 384
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases - Mechanism of action of potential anticancer drugs 379
Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers 378
Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases 373
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione 367
null 361
Inhibition of human placenta glutathione transferase P1-1 by calvatic acid 359
Ketimine rings: useful detectors of enzymatic activities in solution and on polyacrylamide gel: detection of L-amino acid oxidase, glutamine transaminase, pantetheinase, and acylase I 358
Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy 341
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase 335
Inhibition of human placenta glutathione transferase P1-1 by the antibiotic calvatic acid and its diazocyanide analogue--evidence for multiple catalytic intermediates 300
Study on the interaction between the skin detoxifying enzyme glutathione S-transferase and the substances listed in the CE/39/2000 rules with the "skin" annotation, finalized to the biological monitoring of exposed subjects 300
Studying the TRAF2 binding to model membranes: The role of subunits dissociation. 297
The glutathione s-transferase inhibitor 6-(7-Nitro-2,1,3-BenzoxaDiazol-4-ylthio)Hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma. 295
Activation of retinal Müller cells in response to glucose variability 284
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 282
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells 254
Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function 247
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 213
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione 188
Non-symmetrical structural behavior of a symmetric protein: the case of homo-trimeric TRAF2 (tumor necrosis factor-receptor associated factor 2) 176
Thiol-activated anticancer agents: The state of the art 170
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 127
High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells 123
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose 122
Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1 108
Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells 104
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 99
The odd faces of oligomers: The case of traf2-c, a trimeric c-terminal domain of tnf receptor-associated factor 93
Totale 39.464
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Categoria #
all - tutte 90.775
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 90.775
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202190 0 0 0 0 0 0 0 0 0 0 0 90
2021/20221.160 25 142 64 51 38 72 70 50 169 87 101 291
2022/20231.280 139 108 19 165 104 300 119 58 102 3 113 50
2023/2024658 65 18 16 17 40 211 62 36 56 10 6 121
2024/20252.419 114 480 280 133 64 158 150 129 214 163 307 227
2025/20264.430 344 207 515 329 424 159 601 504 499 462 211 175
Totale 40.231