IRIS
CACCURI, ANNA MARIA
 Distribuzione geografica
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Continente #
NA - Nord America 29.848
EU - Europa 2.603
AS - Asia 531
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 9
SA - Sud America 8
AF - Africa 4
Totale 33.012
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Nazione #
US - Stati Uniti d'America 29.828
PL - Polonia 522
UA - Ucraina 419
CN - Cina 374
FR - Francia 326
DE - Germania 320
IE - Irlanda 300
IT - Italia 256
SE - Svezia 167
GB - Regno Unito 124
FI - Finlandia 94
KR - Corea 92
RU - Federazione Russa 34
BE - Belgio 18
CA - Canada 14
IN - India 12
UZ - Uzbekistan 12
JP - Giappone 8
AU - Australia 7
NL - Olanda 7
EU - Europa 6
VN - Vietnam 6
BR - Brasile 5
MY - Malesia 5
TR - Turchia 5
KG - Kirghizistan 4
MX - Messico 4
BD - Bangladesh 3
DZ - Algeria 3
ES - Italia 3
IL - Israele 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AL - Albania 2
CH - Svizzera 2
CO - Colombia 2
JM - Giamaica 2
NZ - Nuova Zelanda 2
PH - Filippine 2
RO - Romania 2
A1 - Anonimo 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
CL - Cile 1
CZ - Repubblica Ceca 1
HK - Hong Kong 1
HU - Ungheria 1
KZ - Kazakistan 1
LK - Sri Lanka 1
MD - Moldavia 1
MK - Macedonia 1
NG - Nigeria 1
NO - Norvegia 1
SG - Singapore 1
TH - Thailandia 1
Totale 33.012
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Città #
Woodbridge 9.225
Wilmington 7.763
Houston 7.453
Fairfield 961
Ann Arbor 793
Kraków 519
Chandler 447
Ashburn 446
Seattle 383
Jacksonville 369
Cambridge 304
Dublin 280
Dearborn 267
Medford 212
New York 179
Rome 137
Beijing 123
Lawrence 101
Zhengzhou 89
Mülheim 73
San Diego 60
Menlo Park 48
Boardman 31
Hefei 26
Falls Church 23
Milan 23
Del Norte 22
Shanghai 19
University Park 18
Mountain View 17
London 16
Nanjing 15
Brussels 14
Hangzhou 14
Norwalk 13
San Mateo 13
Helsinki 12
Phoenix 12
Redwood City 11
Toronto 11
Kunming 10
Palo Alto 9
Seoul 9
Guangzhou 8
Jinan 8
Tappahannock 8
Nanchang 7
Saint Petersburg 6
Verona 6
Acerra 5
Auburn Hills 5
Changsha 5
Chengdu 5
Indiana 5
Melbourne 5
Nürnberg 5
Redmond 5
San Francisco 5
São Paulo 5
Amsterdam 4
Chongqing 4
Clearwater 4
Dong Ket 4
Engelhard 4
Kilburn 4
Kuala Lumpur 4
Center 3
Chicago 3
Detroit 3
Fuzhou 3
Mumbai 3
Paglieta 3
Shenyang 3
Simi Valley 3
Torino 3
Wuhan 3
Atlanta 2
Auckland 2
Aydin 2
Baotou 2
Berlin 2
Chiswick 2
Council Bluffs 2
Creede 2
Eiken 2
Fasano 2
Gentbrugge 2
Hebei 2
Jülich 2
Leawood 2
Legnaro 2
Mexico City 2
Nanning 2
Nepi 2
Padova 2
Prescot 2
Pune 2
Pusan 2
Raleigh 2
San Jose 2
Totale 30.769
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Nome #
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases 483
Proapoptotic activity of new glutathione S-transferase inhibitors 472
Colorimetric and fluorometric assays of glutathione transferase based on 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 465
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells 446
The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex 434
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines 431
Solution structure of glutathione bound to human glutathione transferase P1-1: Comparison of NMR measurements with the crystal structure 430
Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1 428
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells. 425
The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate 423
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer 422
In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma 419
Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1 418
Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy 417
Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. 417
Temperature adaptation of glutathione S-transferase P1-1: a case for homotropic regulation of substrate binding 412
Interaction of hemin with placental glutathione transferase 409
TNFR-Associated Factor-2 (TRAF2): Not only a Trimer 409
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents 407
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 407
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 404
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 404
Binding and kinetic mechanisms of the zeta class glutathione transferase 404
Acidic glutathione transferase from human heart: characterization and N-terminal sequence determination 404
Use of 7-nitro-2,1,3 benzoxadiazole derivatives for anticancer therapy 403
Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences 403
The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. 403
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome 400
Superefficient Enzymes 398
Aggregation of pyrene-labeled microsomal glutathione S-transferase: effect of concentration 396
A novel water-soluble nitrobenzoxadiazole is highly effective against vemurafenib-resistant human melanoma cells 396
S- aminoethyl- l -cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brain 393
Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum 387
Inhibition of glutathione transferase pi from human placenta by 1-chloro-2,4-dinitrobenzene occurs because of covalent reaction with cysteine 47 387
Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process 386
Novel Glutathione S-Transferase Inhibitor Enhances Temozolomide Efficacy Against Malignant Melanoma 52nd Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies 384
Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae) 383
Purification and characterization of a ketimine-reducing enzyme 383
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione s-transferases investigation of ser-9 and tyr-113 in a glutathione s-transferase from the australian sheep blowfly, lucilia cuprina 379
Interaction between 1,4-thiazine derivatives and D-amino-acid oxidase 379
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme 377
Dissociation and unfolding of Pi-class glutathione transferase: evidence for a monomeric inactive intermediate 375
Role of glutathione transferases in the mechanism of brostallicin activation. 374
Structural flexibility modulates the activity of human glutathione transferase P1-1: role of helix 2 flexibility in the catalytic mechanism 374
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases 370
Detection of glutathione transferase activity on polyacrylamide gels 368
Glutathione transferases and development of new principles to overcome drug resistance 367
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. 367
Intrinsic fluorescence quenching of glutathione transferase pi by glutathione binding 367
Investigation of the active site of human placenta glutathione transferase pi by means of a spin-labelled glutathione analogue 364
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma 363
Are the steady state kinetics of glutathione transferase always dependent on the deprotonation of the bound glutathione? New insights in the kinetic mechanism of GST P 1-1 362
Glutathione S-transferase P1-1 as a target for mesothelioma treatment 362
null 361
Redox forms of human placenta glutathione transferase 361
Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart 361
New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1 360
Glutathione-related enzyme activities in testis of patients with malignant diseases 358
N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases 358
Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems. 358
Evolutionary strategy for optimization of GSH binding and catalysis in Alpha, Pi, Mu and theta glutathione transferases 357
Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation 355
Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers 352
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases 351
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 350
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme 339
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 338
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases 337
Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase 331
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. 330
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione 329
Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues 329
Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases 325
Inhibition of human placenta glutathione transferase P1-1 by calvatic acid 315
Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells 315
Ketimine rings: useful detectors of enzymatic activities in solution and on polyacrylamide gel: detection of L-amino acid oxidase, glutamine transaminase, pantetheinase, and acylase I 310
New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains 310
Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy 286
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells: a protection mechanism against excess nitric oxide. 284
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases - Mechanism of action of potential anticancer drugs 281
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase 278
Inhibition of human placenta glutathione transferase P1-1 by the antibiotic calvatic acid and its diazocyanide analogue--evidence for multiple catalytic intermediates 263
The glutathione s-transferase inhibitor 6-(7-Nitro-2,1,3-BenzoxaDiazol-4-ylthio)Hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma. 257
Study on the interaction between the skin detoxifying enzyme glutathione S-transferase and the substances listed in the CE/39/2000 rules with the "skin" annotation, finalized to the biological monitoring of exposed subjects 257
Studying the TRAF2 binding to model membranes: The role of subunits dissociation. 255
Activation of retinal Müller cells in response to glucose variability 210
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 202
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells 192
Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function 176
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 146
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione 139
Non-symmetrical structural behavior of a symmetric protein: the case of homo-trimeric TRAF2 (tumor necrosis factor-receptor associated factor 2) 132
Thiol-activated anticancer agents: The state of the art 127
High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells 48
Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells 46
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 35
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 31
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives 30
The odd faces of oligomers: The case of traf2-c, a trimeric c-terminal domain of tnf receptor-associated factor 26
Nitrobenzoxadiazoles exert anti-melanoma activity modulating the MAPK/JNK signalling 25
Totale 33.156
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Categoria #
all - tutte 57.776
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.776
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.713 0 0 0 0 0 0 0 0 0 0 904 809
2019/20209.290 780 751 607 790 749 1.135 867 851 815 751 547 647
2020/20214.803 516 596 513 634 492 434 619 449 138 131 191 90
2021/20221.160 25 142 64 51 38 72 70 50 169 87 101 291
2022/20231.280 139 108 19 165 104 300 119 58 102 3 113 50
2023/2024531 65 18 16 17 40 211 62 36 56 10 0 0
Totale 33.255