IRIS
CACCURI, ANNA MARIA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 30.204
EU - Europa 2.722
AS - Asia 1.060
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 9
SA - Sud America 9
AF - Africa 4
Totale 34.017
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 30.184
SG - Singapore 525
PL - Polonia 522
UA - Ucraina 419
CN - Cina 377
DE - Germania 334
FR - Francia 326
IE - Irlanda 300
IT - Italia 273
SE - Svezia 167
GB - Regno Unito 124
FI - Finlandia 97
RU - Federazione Russa 95
KR - Corea 92
CZ - Repubblica Ceca 24
BE - Belgio 18
CA - Canada 14
IN - India 12
UZ - Uzbekistan 12
JP - Giappone 9
AU - Australia 7
NL - Olanda 7
EU - Europa 6
VN - Vietnam 6
BR - Brasile 5
MY - Malesia 5
TR - Turchia 5
KG - Kirghizistan 4
MX - Messico 4
BD - Bangladesh 3
CO - Colombia 3
DZ - Algeria 3
ES - Italia 3
IL - Israele 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AL - Albania 2
CH - Svizzera 2
JM - Giamaica 2
NZ - Nuova Zelanda 2
PH - Filippine 2
RO - Romania 2
A1 - Anonimo 1
AT - Austria 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
CL - Cile 1
HK - Hong Kong 1
HU - Ungheria 1
IQ - Iraq 1
KZ - Kazakistan 1
LK - Sri Lanka 1
MD - Moldavia 1
MK - Macedonia 1
NG - Nigeria 1
NO - Norvegia 1
TH - Thailandia 1
Totale 34.017
Salva come PNG Salva come JPEG
Città #
Woodbridge 9.225
Wilmington 7.763
Houston 7.453
Fairfield 961
Ann Arbor 793
Kraków 519
Singapore 461
Ashburn 447
Chandler 447
Seattle 383
Jacksonville 369
Cambridge 304
Dublin 280
Dearborn 267
Medford 212
New York 179
Rome 144
Beijing 123
Santa Clara 111
Lawrence 101
Zhengzhou 89
Mülheim 73
San Diego 60
Moscow 57
Menlo Park 48
Boardman 32
Hefei 26
Brno 23
Falls Church 23
Milan 23
Del Norte 22
Shanghai 19
University Park 18
Mountain View 17
London 16
Nanjing 15
Brussels 14
Hangzhou 14
Helsinki 14
Norwalk 13
Phoenix 13
San Mateo 13
Redwood City 11
Toronto 11
Kunming 10
Palo Alto 9
Seoul 9
Guangzhou 8
Jinan 8
Nuremberg 8
Tappahannock 8
Nanchang 7
Munich 6
Saint Petersburg 6
Verona 6
Acerra 5
Auburn Hills 5
Changsha 5
Chengdu 5
Indiana 5
Melbourne 5
Nürnberg 5
Redmond 5
San Francisco 5
São Paulo 5
Amsterdam 4
Chongqing 4
Clearwater 4
Dong Ket 4
Engelhard 4
Kilburn 4
Kuala Lumpur 4
Center 3
Chicago 3
Detroit 3
Fuzhou 3
Los Angeles 3
Mumbai 3
Paglieta 3
Shenyang 3
Simi Valley 3
Torino 3
Wuhan 3
Atlanta 2
Auckland 2
Aydin 2
Baotou 2
Berlin 2
Chiswick 2
Council Bluffs 2
Creede 2
Eiken 2
Fasano 2
Florence 2
Gentbrugge 2
Hebei 2
Jülich 2
Leawood 2
Legnaro 2
Mexico City 2
Totale 31.436
Salva come PNG Salva come JPEG
Nome #
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases 498
Proapoptotic activity of new glutathione S-transferase inhibitors 488
Colorimetric and fluorometric assays of glutathione transferase based on 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 471
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells 450
The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex 448
Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1 446
The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate 438
Solution structure of glutathione bound to human glutathione transferase P1-1: Comparison of NMR measurements with the crystal structure 435
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines 435
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer 432
TNFR-Associated Factor-2 (TRAF2): Not only a Trimer 430
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells. 428
Temperature adaptation of glutathione S-transferase P1-1: a case for homotropic regulation of substrate binding 426
Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1 426
In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma 425
Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. 423
Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy 421
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 421
The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. 420
Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences 418
Use of 7-nitro-2,1,3 benzoxadiazole derivatives for anticancer therapy 417
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents 415
Interaction of hemin with placental glutathione transferase 413
Aggregation of pyrene-labeled microsomal glutathione S-transferase: effect of concentration 413
Acidic glutathione transferase from human heart: characterization and N-terminal sequence determination 412
Binding and kinetic mechanisms of the zeta class glutathione transferase 411
S- aminoethyl- l -cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brain 411
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 409
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 408
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome 408
Superefficient Enzymes 404
Inhibition of glutathione transferase pi from human placenta by 1-chloro-2,4-dinitrobenzene occurs because of covalent reaction with cysteine 47 403
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme 403
A novel water-soluble nitrobenzoxadiazole is highly effective against vemurafenib-resistant human melanoma cells 403
Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process 401
Novel Glutathione S-Transferase Inhibitor Enhances Temozolomide Efficacy Against Malignant Melanoma 52nd Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies 395
Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum 394
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione s-transferases investigation of ser-9 and tyr-113 in a glutathione s-transferase from the australian sheep blowfly, lucilia cuprina 393
Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae) 392
Purification and characterization of a ketimine-reducing enzyme 387
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases 384
Interaction between 1,4-thiazine derivatives and D-amino-acid oxidase 382
Structural flexibility modulates the activity of human glutathione transferase P1-1: role of helix 2 flexibility in the catalytic mechanism 380
Dissociation and unfolding of Pi-class glutathione transferase: evidence for a monomeric inactive intermediate 380
Role of glutathione transferases in the mechanism of brostallicin activation. 379
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma 378
Intrinsic fluorescence quenching of glutathione transferase pi by glutathione binding 377
Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart 375
Glutathione-related enzyme activities in testis of patients with malignant diseases 374
Glutathione transferases and development of new principles to overcome drug resistance 373
N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases 373
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. 371
Detection of glutathione transferase activity on polyacrylamide gels 370
Investigation of the active site of human placenta glutathione transferase pi by means of a spin-labelled glutathione analogue 368
Redox forms of human placenta glutathione transferase 368
Glutathione S-transferase P1-1 as a target for mesothelioma treatment 368
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases 367
Are the steady state kinetics of glutathione transferase always dependent on the deprotonation of the bound glutathione? New insights in the kinetic mechanism of GST P 1-1 367
New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1 365
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases 364
Evolutionary strategy for optimization of GSH binding and catalysis in Alpha, Pi, Mu and theta glutathione transferases 363
null 361
Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems. 361
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 361
Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation 360
Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers 357
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme 351
Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase 342
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 342
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. 337
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione 336
Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells 335
Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues 333
Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases 328
Ketimine rings: useful detectors of enzymatic activities in solution and on polyacrylamide gel: detection of L-amino acid oxidase, glutamine transaminase, pantetheinase, and acylase I 325
New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains 325
Inhibition of human placenta glutathione transferase P1-1 by calvatic acid 323
Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy 291
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells: a protection mechanism against excess nitric oxide. 290
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases - Mechanism of action of potential anticancer drugs 287
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase 285
Studying the TRAF2 binding to model membranes: The role of subunits dissociation. 267
Inhibition of human placenta glutathione transferase P1-1 by the antibiotic calvatic acid and its diazocyanide analogue--evidence for multiple catalytic intermediates 266
Study on the interaction between the skin detoxifying enzyme glutathione S-transferase and the substances listed in the CE/39/2000 rules with the "skin" annotation, finalized to the biological monitoring of exposed subjects 266
The glutathione s-transferase inhibitor 6-(7-Nitro-2,1,3-BenzoxaDiazol-4-ylthio)Hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma. 263
Activation of retinal Müller cells in response to glucose variability 222
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 207
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells 199
Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function 195
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 151
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione 145
Non-symmetrical structural behavior of a symmetric protein: the case of homo-trimeric TRAF2 (tumor necrosis factor-receptor associated factor 2) 144
Thiol-activated anticancer agents: The state of the art 131
High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells 55
Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells 49
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 43
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 43
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose 35
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives 34
The odd faces of oligomers: The case of traf2-c, a trimeric c-terminal domain of tnf receptor-associated factor 29
Totale 34.071
Salva come PNG Salva come JPEG
Categoria #
all - tutte 64.264
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 64.264
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20207.152 0 0 0 790 749 1.135 867 851 815 751 547 647
2020/20214.803 516 596 513 634 492 434 619 449 138 131 191 90
2021/20221.160 25 142 64 51 38 72 70 50 169 87 101 291
2022/20231.280 139 108 19 165 104 300 119 58 102 3 113 50
2023/2024658 65 18 16 17 40 211 62 36 56 10 6 121
2024/2025878 114 480 280 4 0 0 0 0 0 0 0 0
Totale 34.260