IRIS
CACCURI, ANNA MARIA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 30.234
EU - Europa 2.851
AS - Asia 1.144
SA - Sud America 12
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 9
AF - Africa 5
Totale 34.264
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 30.210
SG - Singapore 574
PL - Polonia 522
UA - Ucraina 420
CN - Cina 389
DE - Germania 344
FR - Francia 326
IE - Irlanda 300
IT - Italia 288
RU - Federazione Russa 188
SE - Svezia 167
GB - Regno Unito 127
FI - Finlandia 100
KR - Corea 92
CZ - Repubblica Ceca 24
BE - Belgio 18
CA - Canada 18
ID - Indonesia 17
IN - India 13
UZ - Uzbekistan 12
JP - Giappone 10
AU - Australia 7
BR - Brasile 7
NL - Olanda 7
VN - Vietnam 7
EU - Europa 6
KG - Kirghizistan 5
MY - Malesia 5
TR - Turchia 5
MX - Messico 4
BD - Bangladesh 3
CO - Colombia 3
DZ - Algeria 3
ES - Italia 3
HK - Hong Kong 3
IL - Israele 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AL - Albania 2
AT - Austria 2
CH - Svizzera 2
JM - Giamaica 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PH - Filippine 2
PT - Portogallo 2
RO - Romania 2
A1 - Anonimo 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
CL - Cile 1
EC - Ecuador 1
HR - Croazia 1
HU - Ungheria 1
IQ - Iraq 1
KZ - Kazakistan 1
LK - Sri Lanka 1
MD - Moldavia 1
MK - Macedonia 1
NO - Norvegia 1
TH - Thailandia 1
Totale 34.264
Salva come PNG Salva come JPEG
Città #
Woodbridge 9.225
Wilmington 7.763
Houston 7.453
Fairfield 961
Ann Arbor 793
Kraków 519
Singapore 510
Ashburn 451
Chandler 447
Seattle 383
Jacksonville 369
Cambridge 304
Dublin 280
Dearborn 267
Medford 212
New York 179
Rome 152
Beijing 124
Santa Clara 112
Lawrence 101
Zhengzhou 89
Mülheim 73
San Diego 60
Moscow 57
Menlo Park 48
Boardman 32
Hefei 26
Brno 23
Falls Church 23
Milan 23
Del Norte 22
Shanghai 19
University Park 18
Jakarta 17
Mountain View 17
Helsinki 16
London 16
Nanjing 15
Brussels 14
Hangzhou 14
Munich 14
Norwalk 13
Phoenix 13
San Mateo 13
Toronto 12
Redwood City 11
Kunming 10
Palo Alto 9
Seoul 9
Guangzhou 8
Jinan 8
Nuremberg 8
Tappahannock 8
Nanchang 7
Saint Petersburg 6
Verona 6
Acerra 5
Auburn Hills 5
Changsha 5
Chengdu 5
Indiana 5
Los Angeles 5
Melbourne 5
Nürnberg 5
Redmond 5
San Francisco 5
São Paulo 5
Amsterdam 4
Chongqing 4
Clearwater 4
Council Bluffs 4
Dong Ket 4
Engelhard 4
Kilburn 4
Kuala Lumpur 4
Shenyang 4
Berlin 3
Center 3
Chicago 3
Detroit 3
Fuzhou 3
Mumbai 3
Ottawa 3
Paglieta 3
Simi Valley 3
Torino 3
Wuhan 3
Atlanta 2
Auckland 2
Aydin 2
Baotou 2
Bishkek 2
Chiswick 2
Creede 2
Eiken 2
Fasano 2
Florence 2
Frankfurt am Main 2
Gentbrugge 2
Hebei 2
Totale 31.532
Salva come PNG Salva come JPEG
Nome #
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases 501
Proapoptotic activity of new glutathione S-transferase inhibitors 491
Colorimetric and fluorometric assays of glutathione transferase based on 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 476
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells 457
The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex 450
Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1 446
The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate 440
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer 438
Solution structure of glutathione bound to human glutathione transferase P1-1: Comparison of NMR measurements with the crystal structure 436
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines 436
TNFR-Associated Factor-2 (TRAF2): Not only a Trimer 431
Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1 430
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells. 429
In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma 428
Temperature adaptation of glutathione S-transferase P1-1: a case for homotropic regulation of substrate binding 426
Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. 425
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 424
Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy 423
The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. 421
Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences 420
Use of 7-nitro-2,1,3 benzoxadiazole derivatives for anticancer therapy 419
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents 418
Aggregation of pyrene-labeled microsomal glutathione S-transferase: effect of concentration 416
Acidic glutathione transferase from human heart: characterization and N-terminal sequence determination 416
Binding and kinetic mechanisms of the zeta class glutathione transferase 414
Interaction of hemin with placental glutathione transferase 414
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 412
S- aminoethyl- l -cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brain 411
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome 410
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 408
A novel water-soluble nitrobenzoxadiazole is highly effective against vemurafenib-resistant human melanoma cells 408
Inhibition of glutathione transferase pi from human placenta by 1-chloro-2,4-dinitrobenzene occurs because of covalent reaction with cysteine 47 406
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme 406
Superefficient Enzymes 404
Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process 402
Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum 399
Novel Glutathione S-Transferase Inhibitor Enhances Temozolomide Efficacy Against Malignant Melanoma 52nd Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies 397
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione s-transferases investigation of ser-9 and tyr-113 in a glutathione s-transferase from the australian sheep blowfly, lucilia cuprina 397
Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae) 393
Purification and characterization of a ketimine-reducing enzyme 388
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases 385
Interaction between 1,4-thiazine derivatives and D-amino-acid oxidase 383
Structural flexibility modulates the activity of human glutathione transferase P1-1: role of helix 2 flexibility in the catalytic mechanism 382
Role of glutathione transferases in the mechanism of brostallicin activation. 381
Intrinsic fluorescence quenching of glutathione transferase pi by glutathione binding 381
Dissociation and unfolding of Pi-class glutathione transferase: evidence for a monomeric inactive intermediate 381
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma 380
Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart 376
Glutathione-related enzyme activities in testis of patients with malignant diseases 375
Glutathione transferases and development of new principles to overcome drug resistance 374
Are the steady state kinetics of glutathione transferase always dependent on the deprotonation of the bound glutathione? New insights in the kinetic mechanism of GST P 1-1 373
Detection of glutathione transferase activity on polyacrylamide gels 373
N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases 373
Glutathione S-transferase P1-1 as a target for mesothelioma treatment 373
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. 372
Investigation of the active site of human placenta glutathione transferase pi by means of a spin-labelled glutathione analogue 371
Redox forms of human placenta glutathione transferase 370
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases 368
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases 367
New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1 366
Evolutionary strategy for optimization of GSH binding and catalysis in Alpha, Pi, Mu and theta glutathione transferases 364
Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems. 362
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 362
null 361
Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation 361
Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers 358
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme 352
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 345
Electron paramagnetic resonance identification of a highly reactive thiol group in the proximity of the catalytic site of human placenta glutathione transferase 344
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. 340
Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells 338
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione 336
Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues 334
Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases 330
New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains 326
Ketimine rings: useful detectors of enzymatic activities in solution and on polyacrylamide gel: detection of L-amino acid oxidase, glutamine transaminase, pantetheinase, and acylase I 325
Inhibition of human placenta glutathione transferase P1-1 by calvatic acid 323
Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy 293
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases - Mechanism of action of potential anticancer drugs 291
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells: a protection mechanism against excess nitric oxide. 291
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase 286
Studying the TRAF2 binding to model membranes: The role of subunits dissociation. 268
Inhibition of human placenta glutathione transferase P1-1 by the antibiotic calvatic acid and its diazocyanide analogue--evidence for multiple catalytic intermediates 267
Study on the interaction between the skin detoxifying enzyme glutathione S-transferase and the substances listed in the CE/39/2000 rules with the "skin" annotation, finalized to the biological monitoring of exposed subjects 267
The glutathione s-transferase inhibitor 6-(7-Nitro-2,1,3-BenzoxaDiazol-4-ylthio)Hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma. 265
Activation of retinal Müller cells in response to glucose variability 224
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 212
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells 201
Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function 198
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 154
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione 147
Non-symmetrical structural behavior of a symmetric protein: the case of homo-trimeric TRAF2 (tumor necrosis factor-receptor associated factor 2) 145
Thiol-activated anticancer agents: The state of the art 132
High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells 59
Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells 56
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 45
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 45
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose 42
null 37
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives 37
Totale 34.293
Salva come PNG Salva come JPEG
Categoria #
all - tutte 67.305
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.305
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20205.613 0 0 0 0 0 1.135 867 851 815 751 547 647
2020/20214.803 516 596 513 634 492 434 619 449 138 131 191 90
2021/20221.160 25 142 64 51 38 72 70 50 169 87 101 291
2022/20231.280 139 108 19 165 104 300 119 58 102 3 113 50
2023/2024658 65 18 16 17 40 211 62 36 56 10 6 121
2024/20251.132 114 480 280 133 64 61 0 0 0 0 0 0
Totale 34.514