Signaling and metabolic pathways are finely regulated by a network of protein phosphorylation events. Unraveling the nature of this intricate network, composed of kinases, target proteins and their interactions, is therefore of crucial importance. Although thousands of kinase-specific phosphorylations have been annotated in model organisms their kinase-target network is far from being complete, with less studied organisms lagging behind.

Parca, L., Ariano, B., Cabibbo, A., Paoletti, M., Tamburrini, A., Palmeri, A., et al. (2018). Kinome-wide identification of phosphorylation networks in Eukaryotic proteomes. BIOINFORMATICS [10.1093/bioinformatics/bty545].

Kinome-wide identification of phosphorylation networks in Eukaryotic proteomes

Parca, Luca
;
Ariano, Bruno;Cabibbo, Andrea;Palmeri, Antonio;Ausiello, Gabriele;Helmer-Citterich, Manuela
2018-07-17

Abstract

Signaling and metabolic pathways are finely regulated by a network of protein phosphorylation events. Unraveling the nature of this intricate network, composed of kinases, target proteins and their interactions, is therefore of crucial importance. Although thousands of kinase-specific phosphorylations have been annotated in model organisms their kinase-target network is far from being complete, with less studied organisms lagging behind.
17-lug-2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11 - BIOLOGIA MOLECOLARE
English
Con Impact Factor ISI
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/bty545/5055125
Parca, L., Ariano, B., Cabibbo, A., Paoletti, M., Tamburrini, A., Palmeri, A., et al. (2018). Kinome-wide identification of phosphorylation networks in Eukaryotic proteomes. BIOINFORMATICS [10.1093/bioinformatics/bty545].
Parca, L; Ariano, B; Cabibbo, A; Paoletti, M; Tamburrini, A; Palmeri, A; Ausiello, G; Helmer-Citterich, M
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Parca_etal2018.pdf

accesso aperto

Licenza: Non specificato
Dimensione 886.12 kB
Formato Adobe PDF
886.12 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/203278
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact