The non-homologous end joining (NHEJ) pathway is involved in the repair of the DNA double-strand breaks. Defects in NHEJ factors result in IR sensitivity, and in defects in V(D)J recombination leading to immunodeficiency. DNA Ligase IV is an essential component that performs the final 'end processing' step of NHEJ. This article is protected by copyright. All rights reserved.
Cifaldi, C., Angelino, G., Chiriaco, M., DI CESARE, S., Claps, A., Serafinelli, J., et al. (2016). Late-onset combined immune-deficiency due to LIGIV mutations in a 12 years old patient. PEDIATRIC ALLERGY AND IMMUNOLOGY [10.1111/pai.12684].
Late-onset combined immune-deficiency due to LIGIV mutations in a 12 years old patient
CHIRIACO, MARIA;DI CESARE, SILVIA;ROSSI, PAOLO;DI MATTEO, GIGLIOLA;CANCRINI, CATERINA;FINOCCHI, ANDREA
2016-11-28
Abstract
The non-homologous end joining (NHEJ) pathway is involved in the repair of the DNA double-strand breaks. Defects in NHEJ factors result in IR sensitivity, and in defects in V(D)J recombination leading to immunodeficiency. DNA Ligase IV is an essential component that performs the final 'end processing' step of NHEJ. This article is protected by copyright. All rights reserved.File in questo prodotto:
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