In this paper, the single-gene regulatory system for the lac operon is considered and a method to build a Boolean network able to represent its dynamics is given. A procedure, based on techniques borrowed from algebraic geometry, to compute an optimal control policy minimising a cost function is given for such a Boolean network. A tool to apply such an optimal control policy to the continuous-time system is reported. The proposed control method is tested in two simulative examples.

Menini, L., Possieri, C., Tornambe', A. (2017). Boolean network representation of a continuous-time system and finite-horizon optimal control: application to the single-gene regulatory system for the lac operon. INTERNATIONAL JOURNAL OF CONTROL, 90(3), 519-552 [10.1080/00207179.2016.1186289].

Boolean network representation of a continuous-time system and finite-horizon optimal control: application to the single-gene regulatory system for the lac operon

MENINI, LAURA;POSSIERI, CORRADO;TORNAMBE', ANTONIO
2017-01-01

Abstract

In this paper, the single-gene regulatory system for the lac operon is considered and a method to build a Boolean network able to represent its dynamics is given. A procedure, based on techniques borrowed from algebraic geometry, to compute an optimal control policy minimising a cost function is given for such a Boolean network. A tool to apply such an optimal control policy to the continuous-time system is reported. The proposed control method is tested in two simulative examples.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ING-INF/04 - AUTOMATICA
English
boolean network; lac operon single-gene regulatory system; optimization; control and systems engineering
www.tandf.co.uk/journals/titles/00207179.asp
Menini, L., Possieri, C., Tornambe', A. (2017). Boolean network representation of a continuous-time system and finite-horizon optimal control: application to the single-gene regulatory system for the lac operon. INTERNATIONAL JOURNAL OF CONTROL, 90(3), 519-552 [10.1080/00207179.2016.1186289].
Menini, L; Possieri, C; Tornambe', A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/169581
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