IRIS
TUNDO, GRAZIA RAFFAELLA
 Distribuzione geografica
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Continente #
NA - Nord America 10.479
AS - Asia 1.364
EU - Europa 1.155
SA - Sud America 274
AF - Africa 22
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 13.298
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Nazione #
US - Stati Uniti d'America 10.430
SG - Singapore 637
CN - Cina 332
IT - Italia 263
BR - Brasile 234
DE - Germania 179
HK - Hong Kong 145
IE - Irlanda 120
UA - Ucraina 106
RU - Federazione Russa 86
FR - Francia 76
GB - Regno Unito 72
SE - Svezia 69
VN - Vietnam 69
PL - Polonia 51
KR - Corea 43
FI - Finlandia 41
NL - Olanda 30
JP - Giappone 29
CA - Canada 28
ID - Indonesia 28
BE - Belgio 17
IN - India 15
MX - Messico 15
ZA - Sudafrica 14
AR - Argentina 13
AT - Austria 13
BD - Bangladesh 12
TR - Turchia 12
EC - Ecuador 9
ES - Italia 8
CL - Cile 7
CZ - Repubblica Ceca 7
PH - Filippine 6
IQ - Iraq 5
PK - Pakistan 5
LT - Lituania 4
UZ - Uzbekistan 4
AZ - Azerbaigian 3
IR - Iran 3
JM - Giamaica 3
JO - Giordania 3
KE - Kenya 3
PY - Paraguay 3
RO - Romania 3
VE - Venezuela 3
AE - Emirati Arabi Uniti 2
CO - Colombia 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
EU - Europa 2
IL - Israele 2
LB - Libano 2
OM - Oman 2
AL - Albania 1
BA - Bosnia-Erzegovina 1
CR - Costa Rica 1
GA - Gabon 1
GR - Grecia 1
GY - Guiana 1
KG - Kirghizistan 1
KH - Cambogia 1
KZ - Kazakistan 1
MA - Marocco 1
MD - Moldavia 1
MK - Macedonia 1
NZ - Nuova Zelanda 1
PE - Perù 1
PS - Palestinian Territory 1
PT - Portogallo 1
PW - Palau 1
SA - Arabia Saudita 1
SC - Seychelles 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
TN - Tunisia 1
UY - Uruguay 1
Totale 13.298
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Città #
Wilmington 2.897
Houston 2.150
Woodbridge 2.102
Fairfield 442
Singapore 384
Ashburn 293
Chandler 237
Ann Arbor 232
Seattle 193
Cambridge 168
New York 153
Hong Kong 142
Beijing 140
Rome 125
Dublin 109
The Dalles 104
Medford 93
Jacksonville 91
Dearborn 77
Los Angeles 65
Santa Clara 63
Dallas 62
Lawrence 42
Council Bluffs 40
Kraków 39
Chicago 35
Buffalo 33
Munich 30
Xi'an 28
La Veta 25
Menlo Park 25
San Diego 25
São Paulo 24
Jakarta 21
San Francisco 19
Ho Chi Minh City 18
Moscow 18
San Jose 17
Hefei 16
Nuremberg 15
Phoenix 15
Tokyo 15
Brussels 14
London 14
Salt Lake City 14
Denver 13
Stockholm 13
Seoul 12
Warsaw 12
Brooklyn 11
Johannesburg 11
Milan 11
Poplar 11
Redondo Beach 11
Rio de Janeiro 11
Hanoi 10
Helsinki 10
Orem 10
Toronto 10
Lappeenranta 9
Montreal 9
Mülheim 9
Redwood City 9
Nanjing 8
Boardman 7
Dong Ket 7
Guangzhou 7
Mexico City 7
Mountain View 7
Nürnberg 7
Arnesano 6
Brno 6
Center 6
Chennai 6
Falls Church 6
Kunming 6
Shanghai 6
Sterling 6
Biên Hòa 5
Chengdu 5
Istanbul 5
Manchester 5
Manila 5
Nanchang 5
Norwalk 5
San Mateo 5
Turku 5
Washington 5
Atlanta 4
Baotou 4
Buenos Aires 4
Chaozhou 4
Curitiba 4
Engelhard 4
Frankfurt am Main 4
Guiyang 4
Haiphong 4
Hangzhou 4
Hải Dương 4
New Delhi 4
Totale 11.252
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Nome #
Role of metalloproteinases in tendon pathophysiology. 486
Proteasome activity is affected by fluctuations in insulin-degrading enzyme distribution 474
Effect of cisplatin on proteasome activity 470
Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations 463
Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes 460
Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity 456
Copper(I) and copper(II) inhibit Abeta peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease 456
Warfarin modulates the nitrite reductase activity of ferrous human serum heme-albumin. 446
Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin 439
Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin. 433
Somatostatin Modulates Insulin-Degrading-Enzyme Metabolism: Implications for the Regulation of Microglia Activity in AD 430
Metal ions affect insulin-degrading enzyme activity 419
Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding. 416
Novel Platinum(II) compounds modulate insulin‑degrading enzyme activity and induce cell death in neuroblastoma cells. 405
Evidence for pH-dependent multiple conformesrs in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding 402
Electrostatic Map of Proteasome α-Rings Encodes the Design of Allosteric Porphyrin-Based Inhibitors Able to Affect 20S Conformation by Cooperative Binding 393
Nitrosylation Mechanisms of Mycobacterium tuberculosis and Campylobacter jejuni Truncated Hemoglobins N, O, and P. 392
Ibuprofen and warfarin modulate allosterically ferrous human serum heme-albumin nitrosylation 386
Enzyme catalysis: the case of the prostate-specific antigen 284
Multiple functions of insulin-degrading enzyme: a metabolic crosslight? 284
The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S 268
Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin 265
null 243
Effects of oral administration of common antioxidant supplements on the energy metabolism of red blood cells. Attenuation of oxidative stress-induced changes in Rett syndrome erythrocytes by CoQ10 225
Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations 225
The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration 221
Insulin-degrading enzyme (IDE): A novel heat shock-like protein 220
On the Horizon: Targeting Next-Generation Immune Checkpoints for Cancer Treatment 219
Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome 219
The proteasome as a druggable target with multiple therapeutic potentialities: cutting and non-cutting edges 184
Functional and spectroscopic characterization of Chlamydomonas reinhardtii truncated hemoglobins 172
Insights into Proteasome Conformation Dynamics and Intersubunit Communication 166
Cationic porphyrins are tunable gatekeepers of the 20S proteasome 157
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo 156
Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells 156
Ferric nitrosylated myoglobin catalyzes peroxynitrite scavenging 153
Structural and functional evidence for citicoline binding and modulation of 20S proteasome activity: novel insights into its pro-proteostatic effect 139
Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways 135
Kinetics of cyanide and carbon monoxide dissociation from ferrous human haptoglobin:hemoglobin(II) complexes 130
The nitrite reductase activity of ferrous human hemoglobin:haptoglobin 1-1 and 2-2 complexes 122
Pyrazolones activate the proteasome by gating mechanisms and protect neuronal cells from β-amyloid toxicity 119
At the cutting edge against cancer: A perspective on immunoproteasome and immune checkpoints modulation as a potential therapeutic intervention 105
The interplay between lipid and Aβ amyloid homeostasis in Alzheimer's disease: risk factors and therapeutic opportunities 89
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose 86
Author Correction: Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome (Scientific Reports, (2017), 7, 1, (12297), 10.1038/s41598-017-12069-0) 85
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects 82
Insulin-degrading enzyme is a non proteasomal target of carfilzomib and affects the 20S proteasome inhibition by the drug 70
Dexamethasone downregulates autophagy through accelerated turn-over of the ulk-1 complex in a trabecular meshwork cells strain: Insights on steroid-induced glaucoma pathogenesis 62
Eye Diseases: When the Solution Comes from Plant Alkaloids 59
High-glucose stimulation triggers early transcription of a panel of proinflammatory mediators in rat Muller glia cells and retina primary explants 56
Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome 56
Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches 53
Modulation of the 20S proteasome activity by porphyrin derivatives is steered through their charge distribution 51
Corrigendum to “Silybins are stereospecific regulators of the 20S proteasome” [Bioorgan. Med. Chem. 66 (2022) 116813] (Bioorganic & Medicinal Chemistry (2022) 66, (S096808962200205X), (10.1016/j.bmc.2022.116813)) 49
Silybins are stereospecific regulators of the 20S proteasome 47
Profiling of the Peripheral Blood Mononuclear Cells Proteome by Shotgun Proteomics Identifies Alterations of Immune System Components, Proteolytic Balance, Autophagy, and Mitochondrial Metabolism in Glaucoma Subjects 46
Hydroxylamine-induced oxidation of ferrous nitrobindins 46
Targeting immunoproteasome in neurodegeneration: a glance to the future 45
A Novel Lactobacillus brevis Fermented with a Vegetable Substrate (AL0035) Counteracts TNBS-Induced Colitis by Modulating the Gut Microbiota Composition and Intestinal Barrier 43
The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design 43
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells’ Ubiquitylome 42
Nitrite Reductase Activity of Ferrous Nitrobindins: A Comparative Study 38
Altered pattern of proteolysis in rhegmatogenous retinal detachment by mining of N-termini datasets from vitreous humor proteome 27
SpectraSage unveils specific proteolytic patterns of 20S on mono-ubiquitylated Tau proteoforms involved in neurodegeneration 12
null 9
Totale 13.589
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Categoria #
all - tutte 37.730
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.730
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021964 0 0 0 0 0 256 245 244 44 78 69 28
2021/2022565 37 77 45 25 18 35 34 20 45 32 39 158
2022/2023576 55 49 16 74 57 120 60 49 43 8 35 10
2023/2024384 82 8 10 7 23 145 12 19 13 10 0 55
2024/20251.538 37 284 139 110 76 120 125 87 96 185 200 79
2025/20261.401 190 165 343 285 276 142 0 0 0 0 0 0
Totale 13.589