Antibodies against tumor necrosis factor represent an effective therapy for patients with inflammatory bowel disease. Despite their successful results, the exact mechanism by which infliximab suppresses intestinal inflammation is still a matter of debate. In this study, we used a translational approach to identify the key mechanisms associated with resolution of mucosal inflammation induced by infliximab.

Caprioli, F., Bosè, F., Rossi, R., Petti, L., Viganò, C., Ciafardini, C., et al. (2013). Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy. INFLAMMATORY BOWEL DISEASES, 19(4), 729-739 [10.1097/MIB.0b013e318280292b].

Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy

MONTELEONE, GIOVANNI;REALI, ENZO
2013-01-01

Abstract

Antibodies against tumor necrosis factor represent an effective therapy for patients with inflammatory bowel disease. Despite their successful results, the exact mechanism by which infliximab suppresses intestinal inflammation is still a matter of debate. In this study, we used a translational approach to identify the key mechanisms associated with resolution of mucosal inflammation induced by infliximab.
2013
Pubblicato
Rilevanza internazionale
Abstract
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Macrophages; Apoptosis; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intestinal Mucosa; Cell Proliferation; Endoscopy; Antibodies, Monoclonal; Microscopy, Fluorescence; Down-Regulation; Antigens, Differentiation, Myelomonocytic; Antigens, CD; Adult; Male; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Wound Healing; Gastrointestinal Agents; Cell Differentiation; Colitis, Ulcerative; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Crohn Disease; Case-Control Studies; Middle Aged; Interleukin-17; Female
Caprioli, F., Bosè, F., Rossi, R., Petti, L., Viganò, C., Ciafardini, C., et al. (2013). Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy. INFLAMMATORY BOWEL DISEASES, 19(4), 729-739 [10.1097/MIB.0b013e318280292b].
Caprioli, F; Bosè, F; Rossi, R; Petti, L; Viganò, C; Ciafardini, C; Raeli, L; Basilisco, G; Ferrero, S; Pagani, M; Conte, D; Altomare, G; Monteleone...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/89792
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