we report herein the 10-year outcome of the Tor Vergata weaning off immunosuppression protocol in hepatitis C virus (HCV) liver transplant patients. thirty-four patients who had received a liver graft for HCV-related cirrhosis were enrolled in a prospective study in which they were progressively weaned off immunosuppression. the primary endpoints were feasibility and safety of the weaning; the second aim was to assess fibrosis progression. at the 10-year follow-up, of the eight original tolerant patients, six remained IS-free. of the 26 individuals who could not be weaned, 22 were alive. when the baseline biopsies were compared with the 10-year biopsies, the tolerant group showed no differences in staging, whereas the nontolerant group showed a significant increase in staging. the fibrosis progression rates calculated for the tolerant and the nontolerant groups were -0.06 ± 0.12 and 0.1 ± 0.2, respectively (P = 0.04). furthermore, with the last taken biopsies, nine nontolerant patients were showing frank cirrhosis versus no cirrhosis among the tolerant patients. after a 10-year follow-up of a tor vergata weaning protocol, 6/34 patients completed follow-up without reinstitution of immunosuppression and this appeared beneficial regarding a reduction in fibrosis progression.

Manzia, T.m., Angelico, R., Baiocchi, L., Toti, L., Ciano, P., Palmieri, G., et al. (2013). The Tor Vergata weaning of immunosuppression protocols in stable hepatitis C virus liver transplant patients: the 10-year follow-up. TRANSPLANT INTERNATIONAL, 26(3), 259-266 [10.1111/tri.12023].

The Tor Vergata weaning of immunosuppression protocols in stable hepatitis C virus liver transplant patients: the 10-year follow-up

MANZIA, TOMMASO MARIA;Angelico, R;BAIOCCHI, LEONARDO;TOTI, LUCA;PALMIERI, GIAMPIERO;ANGELICO, MARIO;TISONE, GIUSEPPE
2013-03-01

Abstract

we report herein the 10-year outcome of the Tor Vergata weaning off immunosuppression protocol in hepatitis C virus (HCV) liver transplant patients. thirty-four patients who had received a liver graft for HCV-related cirrhosis were enrolled in a prospective study in which they were progressively weaned off immunosuppression. the primary endpoints were feasibility and safety of the weaning; the second aim was to assess fibrosis progression. at the 10-year follow-up, of the eight original tolerant patients, six remained IS-free. of the 26 individuals who could not be weaned, 22 were alive. when the baseline biopsies were compared with the 10-year biopsies, the tolerant group showed no differences in staging, whereas the nontolerant group showed a significant increase in staging. the fibrosis progression rates calculated for the tolerant and the nontolerant groups were -0.06 ± 0.12 and 0.1 ± 0.2, respectively (P = 0.04). furthermore, with the last taken biopsies, nine nontolerant patients were showing frank cirrhosis versus no cirrhosis among the tolerant patients. after a 10-year follow-up of a tor vergata weaning protocol, 6/34 patients completed follow-up without reinstitution of immunosuppression and this appeared beneficial regarding a reduction in fibrosis progression.
mar-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06
English
Con Impact Factor ISI
Age Factors; Humans; Disease Progression; Retrospective Studies; Aged; Liver Cirrhosis; Risk Assessment; Hospitals, University; Graft Rejection; Treatment Outcome; Rome; Time Factors; Male; Survival Analysis; Drug Administration Schedule; Sex Factors; Dose-Response Relationship, Drug; Biopsy, Needle; Immunosuppressive Agents; Liver Transplantation; Kaplan-Meier Estimate; Transplantation Immunology; Graft Survival; Cohort Studies; Follow-Up Studies; Middle Aged; Hepatitis C, Chronic; Immunohistochemistry; Female; Immunosuppression
Manzia, T.m., Angelico, R., Baiocchi, L., Toti, L., Ciano, P., Palmieri, G., et al. (2013). The Tor Vergata weaning of immunosuppression protocols in stable hepatitis C virus liver transplant patients: the 10-year follow-up. TRANSPLANT INTERNATIONAL, 26(3), 259-266 [10.1111/tri.12023].
Manzia, Tm; Angelico, R; Baiocchi, L; Toti, L; Ciano, P; Palmieri, G; Angelico, M; Orlando, G; Tisone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/83648
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