A multiscale mechanical model for arterial walls is proposed to describe their age-dependent elastic behavior. The model accounts for nanoscale mechanisms related to molecular and cross-link stretching, as well as for micro- and macroscale effects, by employing homogenization techniques. Such a model uses only a few measurable histological parameters, and allows the reproduction of well-established experimental evidence, highlighting that stiffness of collagen fibrils is related to both cross-link density and their mechanical properties. In the case of aortic walls, the model allows to account for histological alterations occurring with age, fully reproducing available experimental results. Proposed evidence also gives a clear mechanical interpretation of the influence of cross-link density and stiffness on arterial tissue elastic modulus and arterial compliance.

Maceri, F., Marino, M., Vairo, G. (2013). Age-dependent arterial mechanics via a multi scale elastic approach. INTERNATIONAL JOURNAL FOR COMPUTATIONAL METHODS IN ENGINEERING SCIENCE AND MECHANICS, 14(2), 141-151 [10.1080/15502287.2012.744114].

Age-dependent arterial mechanics via a multi scale elastic approach

MACERI, FRANCO;VAIRO, GIUSEPPE
2013-02

Abstract

A multiscale mechanical model for arterial walls is proposed to describe their age-dependent elastic behavior. The model accounts for nanoscale mechanisms related to molecular and cross-link stretching, as well as for micro- and macroscale effects, by employing homogenization techniques. Such a model uses only a few measurable histological parameters, and allows the reproduction of well-established experimental evidence, highlighting that stiffness of collagen fibrils is related to both cross-link density and their mechanical properties. In the case of aortic walls, the model allows to account for histological alterations occurring with age, fully reproducing available experimental results. Proposed evidence also gives a clear mechanical interpretation of the influence of cross-link density and stiffness on arterial tissue elastic modulus and arterial compliance.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ICAR/08 - Scienza delle Costruzioni
English
Con Impact Factor ISI
Age-dependent arterial mechanics; Collagenous tissue; Homogenization methods; Multiscale modeling; Nanoscale nonlinearities
http://www.tandfonline.com/doi/abs/10.1080/15502287.2012.744114
Maceri, F., Marino, M., Vairo, G. (2013). Age-dependent arterial mechanics via a multi scale elastic approach. INTERNATIONAL JOURNAL FOR COMPUTATIONAL METHODS IN ENGINEERING SCIENCE AND MECHANICS, 14(2), 141-151 [10.1080/15502287.2012.744114].
Maceri, F; Marino, M; Vairo, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/82087
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