Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.
Colantoni, A., Bianchi, V., Gherardini, P.F., Scalia Tomba, G., Ausiello, G., Helmer-Citterich, M., et al. (2013). Alternative splicing tends to avoid partial removals of protein-protein interaction sites. BMC GENOMICS, 14, 379-379 [10.1186/1471-2164-14-379].
Tipologia: | Articolo su rivista | |
Citazione: | Colantoni, A., Bianchi, V., Gherardini, P.F., Scalia Tomba, G., Ausiello, G., Helmer-Citterich, M., et al. (2013). Alternative splicing tends to avoid partial removals of protein-protein interaction sites. BMC GENOMICS, 14, 379-379 [10.1186/1471-2164-14-379]. | |
IF: | Con Impact Factor ISI | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore BIO/11 | |
Revisione (peer review): | Esperti anonimi | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/1471-2164-14-379 | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | 7-giu-2013 | |
Titolo: | Alternative splicing tends to avoid partial removals of protein-protein interaction sites | |
Autori: | ||
Autori: | Colantoni, A; Bianchi, V; Gherardini, PF; Scalia Tomba, G; Ausiello, G; Helmer-Citterich, M; Ferrè, F | |
Appare nelle tipologie: | 01 - Articolo su rivista |
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