Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.
Colantoni, A., Bianchi, V., Gherardini, P., SCALIA TOMBA, G., Ausiello, G., HELMER CITTERICH, M., et al. (2013). Alternative splicing tends to avoid partial removals of protein-protein interaction sites. BMC GENOMICS, 14, 379-379 [10.1186/1471-2164-14-379].
Alternative splicing tends to avoid partial removals of protein-protein interaction sites
Gherardini, PF;SCALIA TOMBA, GIANPAOLO;AUSIELLO, GABRIELE;HELMER CITTERICH, MANUELA;
2013-06-07
Abstract
Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.File | Dimensione | Formato | |
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