Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.

Colantoni, A., Bianchi, V., Gherardini, P., SCALIA TOMBA, G., Ausiello, G., HELMER CITTERICH, M., et al. (2013). Alternative splicing tends to avoid partial removals of protein-protein interaction sites. BMC GENOMICS, 14, 379-379 [10.1186/1471-2164-14-379].

Alternative splicing tends to avoid partial removals of protein-protein interaction sites

Gherardini, PF;SCALIA TOMBA, GIANPAOLO;AUSIELLO, GABRIELE;HELMER CITTERICH, MANUELA;
2013-06-07

Abstract

Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.
7-giu-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11 - BIOLOGIA MOLECOLARE
English
Con Impact Factor ISI
Colantoni, A., Bianchi, V., Gherardini, P., SCALIA TOMBA, G., Ausiello, G., HELMER CITTERICH, M., et al. (2013). Alternative splicing tends to avoid partial removals of protein-protein interaction sites. BMC GENOMICS, 14, 379-379 [10.1186/1471-2164-14-379].
Colantoni, A; Bianchi, V; Gherardini, P; SCALIA TOMBA, G; Ausiello, G; HELMER CITTERICH, M; Ferrè, F
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
bmc genomics.pdf

accesso aperto

Dimensione 1.26 MB
Formato Adobe PDF
1.26 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/78693
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact