Psoriasis is a common (1-3% of the population worldwide), multifactorial, immune-mediated chronic skin disease. In psoriasis pathogenesis an over-reaction of local innate immune response initiates inflammation with subsequent involvement of adaptive immune response leading to the production of a panel of cytokines, chemokines and growth factors leading to epidermal hyperplasia. Recently, IL-21 has been involved in this process as this cytokine is overexpressed in psoriatic skin and can cause epidermal hyperplasia and inflammation when injected intradermally into mice. Moreover blockade of IL-21 with a human antibody against IL-21 reduces the epidermal thickness and the expression of Th1 and Th17 genes in the well-characterized model of human psoriasis-xenograft mouse. Therefore, the inhibition of this cytokine may be therapeutically effective in the treatment of psoriasis. Here we will review recent data on psoriasis pathogenesis focusing on the role of IL-21 as novel therapeutic target.

Botti, E., Spallone, G., Caruso, R., Monteleone, G., Chimenti, S., Costanzo, A. (2012). Psoriasis, from pathogenesis to therapeutic strategies: IL-21 as a novel potential therapeutic target. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 13(10), 1861-1867.

Psoriasis, from pathogenesis to therapeutic strategies: IL-21 as a novel potential therapeutic target

Botti, E;SPALLONE, GIULIA;MONTELEONE, GIOVANNI;CHIMENTI, SERGIO;COSTANZO, ANTONIO
2012-08-01

Abstract

Psoriasis is a common (1-3% of the population worldwide), multifactorial, immune-mediated chronic skin disease. In psoriasis pathogenesis an over-reaction of local innate immune response initiates inflammation with subsequent involvement of adaptive immune response leading to the production of a panel of cytokines, chemokines and growth factors leading to epidermal hyperplasia. Recently, IL-21 has been involved in this process as this cytokine is overexpressed in psoriatic skin and can cause epidermal hyperplasia and inflammation when injected intradermally into mice. Moreover blockade of IL-21 with a human antibody against IL-21 reduces the epidermal thickness and the expression of Th1 and Th17 genes in the well-characterized model of human psoriasis-xenograft mouse. Therefore, the inhibition of this cytokine may be therapeutically effective in the treatment of psoriasis. Here we will review recent data on psoriasis pathogenesis focusing on the role of IL-21 as novel therapeutic target.
ago-2012
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/35 - MALATTIE CUTANEE E VENEREE
Settore MED/12 - GASTROENTEROLOGIA
English
Con Impact Factor ISI
antibodies, monoclonal; anti-inflammatory agents; dendritic cells; animals; psoriasis; humans; interleukins; immunity, innate; keratinocytes; immunosuppressive agents; t-lymphocytes
Botti, E., Spallone, G., Caruso, R., Monteleone, G., Chimenti, S., Costanzo, A. (2012). Psoriasis, from pathogenesis to therapeutic strategies: IL-21 as a novel potential therapeutic target. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 13(10), 1861-1867.
Botti, E; Spallone, G; Caruso, R; Monteleone, G; Chimenti, S; Costanzo, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/78223
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