HCV-related disease is the most common indication for liver transplantation (LT). HCV recurrence, which is almost universal, has a significant impact on patient and graft survival after LT and still represents a great unsolved issue for the liver transplant community. Several treatment strategies have been proposed. Since antiviral therapy has limited efficacy and can be administrated only in selected transplant recipients and additionally that immunosuppressive drugs have a negative impact on HCV re-infection, the achievement of an immunosuppression-free state after LT could play a central role in the avoidance of rapid HCV recurrence.

Manzia, T.m., Angelico, R., Toti, L., Lai, Q., Ciano, P., Angelico, M., et al. (2012). Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 8(7), 635-644 [10.1586/eci.12.66].

Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation.

MANZIA, TOMMASO MARIA;Angelico, R;TOTI, LUCA;ANGELICO, MARIO;TISONE, GIUSEPPE
2012-09-01

Abstract

HCV-related disease is the most common indication for liver transplantation (LT). HCV recurrence, which is almost universal, has a significant impact on patient and graft survival after LT and still represents a great unsolved issue for the liver transplant community. Several treatment strategies have been proposed. Since antiviral therapy has limited efficacy and can be administrated only in selected transplant recipients and additionally that immunosuppressive drugs have a negative impact on HCV re-infection, the achievement of an immunosuppression-free state after LT could play a central role in the avoidance of rapid HCV recurrence.
set-2012
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Con Impact Factor ISI
clinical operational tolerance; HCV recurrence; hepatitis C; immunosuppression; liver transplantation
Manzia, T.m., Angelico, R., Toti, L., Lai, Q., Ciano, P., Angelico, M., et al. (2012). Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 8(7), 635-644 [10.1586/eci.12.66].
Manzia, Tm; Angelico, R; Toti, L; Lai, Q; Ciano, P; Angelico, M; Tisone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/77007
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