As reported (Engelen MPKJ et al. Am J Clin Nutr 1998;68:1298-1303) patients with severe emphysema present an altered bone mineral density (BMD). Our study aims in identifying the impact of lung volume reduction surgery (LVRS) on BMD. Nineteen patients operated for severe emphysema, were studied preoperatively and 12 months postoperatively with dual-energy X-ray absorptiometry (DEXA). At the same time a control group of 15 coetaneous no-smokers subjects without lung disease underwent the same investigation. Correlations between the changes of bone mass and clinical variables, glucocorticoid use, and biochemical markers of bone metabolism were analyzed. At the baseline a hip or spine T-score <-2.5 was evidenced in 63% (n=12/19) of emphysematous patients while in 26% (n=4/15) the control group (p= 0.001). After surgery, significant improvements in hip BMD (0.69±0.10 vs 0.74±0.11, p=0.02), spine BMD (0.87±0.14 vs 92.8±0.16, p=0.03), hip T-score (-2.39±0.86 vs –2.27±0.90, p=0.04), hip Z-score (-0.85±0.9 vs -0.70±1.0, Z% 87.9 vs 90.8, p=0.05), spine T-score (-2.16±1.24 vs –1.70±1.14, p=0.04), spine Z-score (-1.45±1.34 vs –1.09±1.50, Z% 84.2 vs 89.3 p=0.05) were found. Improvements of spine Z%-score were significantly correlated with residual volume (p=0.05), 6-minutes walking (p=0.04), quality of life (p=0.01) and steroids quitting (p=0.03) changes. No other significant correlations were found. LVRS significantly improved BMD, T- and Z-score in both hip and spine districts. The effect may be related to steroid quitting and increased exercise.
Ambrogi, V., Fabbri, A., Pompeo, E., Mineo, D., Fabbrini, E., Mineo, T.c. (2002). Changes in bone mineral density after lung volume reduction surgery for severe emphysema. ??????? it.cilea.surplus.oa.citation.tipologie.CitationProceedings.prensentedAt ??????? 12th Annual Congress of the European Respiratory Society, Stoccolma.
Changes in bone mineral density after lung volume reduction surgery for severe emphysema
AMBROGI, VINCENZO;FABBRI, ANDREA;POMPEO, EUGENIO;MINEO, TOMMASO CLAUDIO
2002-01-01
Abstract
As reported (Engelen MPKJ et al. Am J Clin Nutr 1998;68:1298-1303) patients with severe emphysema present an altered bone mineral density (BMD). Our study aims in identifying the impact of lung volume reduction surgery (LVRS) on BMD. Nineteen patients operated for severe emphysema, were studied preoperatively and 12 months postoperatively with dual-energy X-ray absorptiometry (DEXA). At the same time a control group of 15 coetaneous no-smokers subjects without lung disease underwent the same investigation. Correlations between the changes of bone mass and clinical variables, glucocorticoid use, and biochemical markers of bone metabolism were analyzed. At the baseline a hip or spine T-score <-2.5 was evidenced in 63% (n=12/19) of emphysematous patients while in 26% (n=4/15) the control group (p= 0.001). After surgery, significant improvements in hip BMD (0.69±0.10 vs 0.74±0.11, p=0.02), spine BMD (0.87±0.14 vs 92.8±0.16, p=0.03), hip T-score (-2.39±0.86 vs –2.27±0.90, p=0.04), hip Z-score (-0.85±0.9 vs -0.70±1.0, Z% 87.9 vs 90.8, p=0.05), spine T-score (-2.16±1.24 vs –1.70±1.14, p=0.04), spine Z-score (-1.45±1.34 vs –1.09±1.50, Z% 84.2 vs 89.3 p=0.05) were found. Improvements of spine Z%-score were significantly correlated with residual volume (p=0.05), 6-minutes walking (p=0.04), quality of life (p=0.01) and steroids quitting (p=0.03) changes. No other significant correlations were found. LVRS significantly improved BMD, T- and Z-score in both hip and spine districts. The effect may be related to steroid quitting and increased exercise.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
