Helicobacter pylori (Hp) infection causes a chronic gastric inflammation, which can lead to peptic ulceration and cancer. The inflammatory response is multifactorial and is characterized by exaggerated Th1 cytokine production. How the Th1 response is induced and maintained in the stomach of Hp-infected patients remains unclear. Transforming growth factor (TGF)-beta 1 negatively regulates Th1 cell development, and TGF-beta 1-deficient mice spontaneously develop gastritis. Here, we examined TGF-beta 1 signaling in Hp-associated gastritis.

Monteleone, G., DEL VECCHIO BLANCO, G., Palmieri, G., Vavassori, P., Monteleone, I., Colantoni, A., et al. (2004). Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. GASTROENTEROLOGY, 126(3), 674-682 [10.1053/j.gastro.2003.11.048].

Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection

MONTELEONE, GIOVANNI;PALMIERI, GIAMPIERO;MONTELEONE, IVAN;COLANTONI, ALFREDO;SPAGNOLI, LUIGI GIUSTO;PALLONE, FRANCESCO
2004-03-01

Abstract

Helicobacter pylori (Hp) infection causes a chronic gastric inflammation, which can lead to peptic ulceration and cancer. The inflammatory response is multifactorial and is characterized by exaggerated Th1 cytokine production. How the Th1 response is induced and maintained in the stomach of Hp-infected patients remains unclear. Transforming growth factor (TGF)-beta 1 negatively regulates Th1 cell development, and TGF-beta 1-deficient mice spontaneously develop gastritis. Here, we examined TGF-beta 1 signaling in Hp-associated gastritis.
mar-2004
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
English
Helicobacter pylori; Interferon-gamma; Smad3 Protein; DNA-Binding Proteins; Humans; Aged; Helicobacter Infections; T-Box Domain Proteins; Transforming Growth Factor beta1; Transcription Factors; Phosphorylation; Down-Regulation; Adult; Gastric Mucosa; Smad7 Protein; Enzyme-Linked Immunosorbent Assay; Transforming Growth Factor beta; Gene Expression Regulation; Trans-Activators; Organ Culture Techniques; Signal Transduction; Female; Male
Monteleone, G., DEL VECCHIO BLANCO, G., Palmieri, G., Vavassori, P., Monteleone, I., Colantoni, A., et al. (2004). Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. GASTROENTEROLOGY, 126(3), 674-682 [10.1053/j.gastro.2003.11.048].
Monteleone, G; DEL VECCHIO BLANCO, G; Palmieri, G; Vavassori, P; Monteleone, I; Colantoni, A; Battista, S; Spagnoli, Lg; Romano, M; Borrelli, M; Macdonald, T; Pallone, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/70743
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