Helicobacter pylori (Hp) infection causes a chronic gastric inflammation, which can lead to peptic ulceration and cancer. The inflammatory response is multifactorial and is characterized by exaggerated Th1 cytokine production. How the Th1 response is induced and maintained in the stomach of Hp-infected patients remains unclear. Transforming growth factor (TGF)-beta 1 negatively regulates Th1 cell development, and TGF-beta 1-deficient mice spontaneously develop gastritis. Here, we examined TGF-beta 1 signaling in Hp-associated gastritis.
Monteleone, G., DEL VECCHIO BLANCO, G., Palmieri, G., Vavassori, P., Monteleone, I., Colantoni, A., et al. (2004). Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. GASTROENTEROLOGY, 126(3), 674-682 [10.1053/j.gastro.2003.11.048].
Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection
MONTELEONE, GIOVANNI;PALMIERI, GIAMPIERO;MONTELEONE, IVAN;COLANTONI, ALFREDO;SPAGNOLI, LUIGI GIUSTO;PALLONE, FRANCESCO
2004-03-01
Abstract
Helicobacter pylori (Hp) infection causes a chronic gastric inflammation, which can lead to peptic ulceration and cancer. The inflammatory response is multifactorial and is characterized by exaggerated Th1 cytokine production. How the Th1 response is induced and maintained in the stomach of Hp-infected patients remains unclear. Transforming growth factor (TGF)-beta 1 negatively regulates Th1 cell development, and TGF-beta 1-deficient mice spontaneously develop gastritis. Here, we examined TGF-beta 1 signaling in Hp-associated gastritis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
