The recommended prophylaxis against hepatitis B virus recurrence after liver transplantation based on hepatitis B immunoglobulins and lamivudine is highly expensive. A recent study reported a significant anti-HBs (antibodies against hepatitis B surface antigen) response after a reinforced vaccination against hepatitis B virus, a result not confirmed in a study from our group. Concomitant lamivudine treatment and the achievement of complete washout of anti-hepatitis B-specific immunoglobulin prior to vaccination in our study could explain the contradiction.

DI PAOLO, D., Lenci, I., Trinito, M., Carbone, M., Longhi, C., Tisone, G., et al. (2006). Extended double-dosage HBV vaccination after liver transplantation is ineffective, in the absence of lamivudine and prior wash-out of human Hepatitis B immunoglobulins. DIGESTIVE AND LIVER DISEASE, 38(10), 749-754 [10.1016/j.dld.2006.06.011].

Extended double-dosage HBV vaccination after liver transplantation is ineffective, in the absence of lamivudine and prior wash-out of human Hepatitis B immunoglobulins

DI PAOLO, DANIELE;TISONE, GIUSEPPE;ANGELICO, MARIO
2006-10-01

Abstract

The recommended prophylaxis against hepatitis B virus recurrence after liver transplantation based on hepatitis B immunoglobulins and lamivudine is highly expensive. A recent study reported a significant anti-HBs (antibodies against hepatitis B surface antigen) response after a reinforced vaccination against hepatitis B virus, a result not confirmed in a study from our group. Concomitant lamivudine treatment and the achievement of complete washout of anti-hepatitis B-specific immunoglobulin prior to vaccination in our study could explain the contradiction.
ott-2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Con Impact Factor ISI
Hepatitis B Antibodies; Humans; Adult; Hepatitis B; Lamivudine; Hepatitis B Vaccines; Middle Aged; Male; Liver Transplantation; Reverse Transcriptase Inhibitors; Immunoglobulins
DI PAOLO, D., Lenci, I., Trinito, M., Carbone, M., Longhi, C., Tisone, G., et al. (2006). Extended double-dosage HBV vaccination after liver transplantation is ineffective, in the absence of lamivudine and prior wash-out of human Hepatitis B immunoglobulins. DIGESTIVE AND LIVER DISEASE, 38(10), 749-754 [10.1016/j.dld.2006.06.011].
DI PAOLO, D; Lenci, I; Trinito, M; Carbone, M; Longhi, C; Tisone, G; Angelico, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66354
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