Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.
Liuzzi, F., Fanelli, C., Ciriolo, M.R., Cerella, C., D'Alessio, M., Denicola, M., et al. (2003). Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. In APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS.
Autori: | |
Autori: | Liuzzi, F; Fanelli, C; Ciriolo, MR; Cerella, C; D'Alessio, M; Denicola, M; Magrini, A; Bergamaschi, A; Ghibelli, L |
Titolo: | Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion |
Nome del convegno: | 5th International Conference on Apoptosis from Signalling Pathways to Therapeutic Tools |
Luogo del convegno: | LUXEMBOURG, LUXEMBOURG |
Anno del convegno: | JAN 29-FEB 01, 2003 |
Rilevanza: | Rilevanza internazionale |
Data di pubblicazione: | 2003 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1196/annals.1299.080 |
Settore Scientifico Disciplinare: | Settore MED/44 - Medicina del Lavoro |
Lingua: | English |
Tipologia: | Intervento a convegno |
Citazione: | Liuzzi, F., Fanelli, C., Ciriolo, M.R., Cerella, C., D'Alessio, M., Denicola, M., et al. (2003). Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. In APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS. |
Appare nelle tipologie: | 02 - Intervento a convegno |