The aryl hydrocarbon receptor (AhR), a transcription factor activated by a large number of environmental agents, modulates the activity of immune and nonimmune cells in the gut, and may represent an important link between the environment and the immune perturbations which underlie the pathogenesis of inflammatory bowel disease. This review will summarize the current knowledge of the role of AhR in regulation of intestinal immune homeostasis and inflammation.
Monteleone, I., Macdonald, T., Pallone, F., Monteleone, G. (2012). The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis. CURRENT OPINION IN GASTROENTEROLOGY, 28(4), 310-313 [10.1097/MOG.0b013e328352ad69].
The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis
MONTELEONE, IVAN;PALLONE, FRANCESCO;MONTELEONE, GIOVANNI
2012-07-01
Abstract
The aryl hydrocarbon receptor (AhR), a transcription factor activated by a large number of environmental agents, modulates the activity of immune and nonimmune cells in the gut, and may represent an important link between the environment and the immune perturbations which underlie the pathogenesis of inflammatory bowel disease. This review will summarize the current knowledge of the role of AhR in regulation of intestinal immune homeostasis and inflammation.Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons
