A 64-year-old man with HBV-related cirrhosis presented with a liver nodule measuring 2.8 cm revealed by a routine ultrasound and concomitant increased alpha-fetoprotein (AFP) up to 400 UI/l. Contrast-enhanced CT was suggestive of hepatocellular carcinoma (HCC) and the patient underwent laser ablation procedure. Five months later, because of raised AFP up to 1600 UI/l, ultrasonography and abdominal CT were repeated, showing an increased diameter of liver nodule, measuring 3.8 cm. The patient underwent down-staged trans-arterial chemoembolization (TACE) and then was entered into the active liver transplant (LT) list. Lamivudine was already started and the patient underwent LT showing HBV-DNA serum levels < 10(3) log/copies at the time of surgery. Pathological analysis performed on the explanted liver showed, instead of the suspected HCC, hepatic yolk sac tumor with the presence of typical 'Schiller-Duval bodies'. The first 12 months of postoperative follow-up were excellent, with no evidence of tumor recurrence.

Lenci, I., Tariciotti, L., Baiocchi, L., Manzia, T.m., Toti, L., Craboledda, P., et al. (2008). Primary yolk sac tumor of the liver: incidental finding in a patient transplanted for hepatocellular carcinoma. TRANSPLANT INTERNATIONAL, 21(6), 598-601 [10.1111/j.1432-2277.2008.00667.x].

Primary yolk sac tumor of the liver: incidental finding in a patient transplanted for hepatocellular carcinoma

BAIOCCHI, LEONARDO;MANZIA, TOMMASO MARIA;TOTI, LUCA;ANGELICO, MARIO;TISONE, GIUSEPPE
2008-01-01

Abstract

A 64-year-old man with HBV-related cirrhosis presented with a liver nodule measuring 2.8 cm revealed by a routine ultrasound and concomitant increased alpha-fetoprotein (AFP) up to 400 UI/l. Contrast-enhanced CT was suggestive of hepatocellular carcinoma (HCC) and the patient underwent laser ablation procedure. Five months later, because of raised AFP up to 1600 UI/l, ultrasonography and abdominal CT were repeated, showing an increased diameter of liver nodule, measuring 3.8 cm. The patient underwent down-staged trans-arterial chemoembolization (TACE) and then was entered into the active liver transplant (LT) list. Lamivudine was already started and the patient underwent LT showing HBV-DNA serum levels < 10(3) log/copies at the time of surgery. Pathological analysis performed on the explanted liver showed, instead of the suspected HCC, hepatic yolk sac tumor with the presence of typical 'Schiller-Duval bodies'. The first 12 months of postoperative follow-up were excellent, with no evidence of tumor recurrence.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - Gastroenterologia
English
Con Impact Factor ISI
Hepatocellular carcinoma; Liver transplantation; Yolk sac tumor
alpha fetoprotein; cyclosporin A; lamivudine; adult; anamnesis; article; cancer diagnosis; case report; chemoembolization; clinical feature; computer assisted tomography; differential diagnosis; follow up; human; immunoprophylaxis; laser surgery; liver cell carcinoma; liver graft; liver transplantation; liver tumor; male; priority journal; tumor volume; yolk sac tumor; Carcinoma, Hepatocellular; Diagnostic Errors; Endodermal Sinus Tumor; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged
Lenci, I., Tariciotti, L., Baiocchi, L., Manzia, T.m., Toti, L., Craboledda, P., et al. (2008). Primary yolk sac tumor of the liver: incidental finding in a patient transplanted for hepatocellular carcinoma. TRANSPLANT INTERNATIONAL, 21(6), 598-601 [10.1111/j.1432-2277.2008.00667.x].
Lenci, I; Tariciotti, L; Baiocchi, L; Manzia, Tm; Toti, L; Craboledda, P; Callea, F; Angelico, M; Tisone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/57938
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