OBJECTIVE: Because leptin, the adipocyte-derived hormone, affects thymocyte survival, proliferation of naïve T lymphocytes and the production of proinflammatory cytokines, we aimed to investigate the role of this molecule in immunoreconstitution during highly active antiretroviral therapy (HAART). DESIGN: Prospective longitudinal cohort study. A series of 20 HIV+ children were studied. The subjects were grouped by their increase in serum leptin levels after HAART. METHODS: All participants were weight-stable, free of endocrine disorders and opportunistic infections and equally distributed for sex (males, n = 10; females, n = 10). Body mass index (BMI), serum lipids, leptin, CD4+ T cells and HIV-1 RNA were measured before initiation of HAART and after a 2-year follow-up. RESULTS: Serum leptin concentration positively correlated with CD4+ lymphocyte number before treatment. HAART significantly reduced viraemia and increased serum levels of lipids in all patients, whereas a significant increase in CD4+ cells and serum leptin was observed in the majority of patients. Notably, in children where HAART was not effective in increasing CD4+ lymphocyte counts, serum leptin did not increase. CONCLUSION: To our knowledge, these findings reveal for the first time a novel link among CD4+ T lymphocytes, serum leptin and highly active anteretroviral theraphy.

Matarese, G., Castelli Gattinara, G., Cancrini, C., Bernardi, S., Romiti, M.l., Savarese, C., et al. (2002). Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy, 57(5), 643-646 [10.1046/j.1365-2265.2002.01634.x].

Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy

CANCRINI, CATERINA;ROSSI, PAOLO;
2002-01-01

Abstract

OBJECTIVE: Because leptin, the adipocyte-derived hormone, affects thymocyte survival, proliferation of naïve T lymphocytes and the production of proinflammatory cytokines, we aimed to investigate the role of this molecule in immunoreconstitution during highly active antiretroviral therapy (HAART). DESIGN: Prospective longitudinal cohort study. A series of 20 HIV+ children were studied. The subjects were grouped by their increase in serum leptin levels after HAART. METHODS: All participants were weight-stable, free of endocrine disorders and opportunistic infections and equally distributed for sex (males, n = 10; females, n = 10). Body mass index (BMI), serum lipids, leptin, CD4+ T cells and HIV-1 RNA were measured before initiation of HAART and after a 2-year follow-up. RESULTS: Serum leptin concentration positively correlated with CD4+ lymphocyte number before treatment. HAART significantly reduced viraemia and increased serum levels of lipids in all patients, whereas a significant increase in CD4+ cells and serum leptin was observed in the majority of patients. Notably, in children where HAART was not effective in increasing CD4+ lymphocyte counts, serum leptin did not increase. CONCLUSION: To our knowledge, these findings reveal for the first time a novel link among CD4+ T lymphocytes, serum leptin and highly active anteretroviral theraphy.
2002
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
antiretrovirus agent; indinavir; lamivudine; leptin; lipid; nelfinavir; proteinase inhibitor; RNA directed DNA polymerase inhibitor; stavudine; virus RNA; zidovudine; article; body mass; child; clinical article; controlled study; endocrine disease; female; follow up; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; lipid blood level; lymphocyte count; male; opportunistic infection; priority journal; protein blood level; T lymphocyte subpopulation; treatment outcome; Antiretroviral Therapy, Highly Active; Body Mass Index; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Child; Child, Preschool; Female; Follow-Up Studies; HIV Seropositivity; Humans; Leptin; Lipids; Male; Prospective Studies; Statistics, Nonparametric; Viral Load
Matarese, G., Castelli Gattinara, G., Cancrini, C., Bernardi, S., Romiti, M.l., Savarese, C., et al. (2002). Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy, 57(5), 643-646 [10.1046/j.1365-2265.2002.01634.x].
Matarese, G; Castelli Gattinara, G; Cancrini, C; Bernardi, S; Romiti, Ml; Savarese, C; Di Giacomo, A; Rossi, P; Racioppi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/57603
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