OBJECTIVE: Because leptin, the adipocyte-derived hormone, affects thymocyte survival, proliferation of naÃ¯ve T lymphocytes and the production of proinflammatory cytokines, we aimed to investigate the role of this molecule in immunoreconstitution during highly active antiretroviral therapy (HAART). DESIGN: Prospective longitudinal cohort study. A series of 20 HIV+ children were studied. The subjects were grouped by their increase in serum leptin levels after HAART. METHODS: All participants were weight-stable, free of endocrine disorders and opportunistic infections and equally distributed for sex (males, n = 10; females, n = 10). Body mass index (BMI), serum lipids, leptin, CD4+ T cells and HIV-1 RNA were measured before initiation of HAART and after a 2-year follow-up. RESULTS: Serum leptin concentration positively correlated with CD4+ lymphocyte number before treatment. HAART significantly reduced viraemia and increased serum levels of lipids in all patients, whereas a significant increase in CD4+ cells and serum leptin was observed in the majority of patients. Notably, in children where HAART was not effective in increasing CD4+ lymphocyte counts, serum leptin did not increase. CONCLUSION: To our knowledge, these findings reveal for the first time a novel link among CD4+ T lymphocytes, serum leptin and highly active anteretroviral theraphy.
Matarese G., C.G. (2002). Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy. Clinical Endocrinology, 57(5), 643-646.
|Tipologia:||Articolo su rivista|
|Citazione:||Matarese G., C.G. (2002). Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy. Clinical Endocrinology, 57(5), 643-646.|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1046/j.1365-2265.2002.01634.x|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2002|
|Titolo:||Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy|
|Autori:||Matarese G., Castelli-Gattinara G., Cancrini C., Bernardi S., Romiti M.L., Savarese C., Di Giacomo A., Rossi P., Racioppi L.|
|Appare nelle tipologie:||01 - Articolo su rivista|