Prolonged treatment with antiretroviral agents directed against reverse transcription (RT) in patients with HIV-1 infection results in the emergence of virus variants with reduced sensitivity containing mutations in the HIV-1 RT gene. Development of zidovudine (ZDV)-related mutations was studied in a cohort of 24 vertically infected pediatric patients receiving ZDV therapy. Monthly clinical and immunologic evaluation was accompanied by direct sequencing of the HIV-1 RT gene every 4 months. A correlation was observed between the emergence of mutations and the duration of therapy. Mutation at codon 41 was found only in the presence of mutation at codon 215. The presence of the mutations Met(41)-->Leu and Thr(215)-->Tyr/Phe did not appear to be related to disease progression. These findings suggest that the mere presence of mutations in the HIV-1 RT gene alone during ZDV monotherapy is net a reliable prognostic marker in the absence of other clinical and virologic information.

Orlandi, P., Cancrini, C., Scaccia, S., Romiti, M.l., Livadiotti, S., Gattinara, G.c., et al. (1998). Analysis of HIV-1 reverse transcriptase gene mutations in infected children treated with zidovudine. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 19(3), 230-237.

Analysis of HIV-1 reverse transcriptase gene mutations in infected children treated with zidovudine

CANCRINI, CATERINA;ANGELINI, FEDERICA;ROSSI, PAOLO
1998-01-01

Abstract

Prolonged treatment with antiretroviral agents directed against reverse transcription (RT) in patients with HIV-1 infection results in the emergence of virus variants with reduced sensitivity containing mutations in the HIV-1 RT gene. Development of zidovudine (ZDV)-related mutations was studied in a cohort of 24 vertically infected pediatric patients receiving ZDV therapy. Monthly clinical and immunologic evaluation was accompanied by direct sequencing of the HIV-1 RT gene every 4 months. A correlation was observed between the emergence of mutations and the duration of therapy. Mutation at codon 41 was found only in the presence of mutation at codon 215. The presence of the mutations Met(41)-->Leu and Thr(215)-->Tyr/Phe did not appear to be related to disease progression. These findings suggest that the mere presence of mutations in the HIV-1 RT gene alone during ZDV monotherapy is net a reliable prognostic marker in the absence of other clinical and virologic information.
1998
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Children Zidovudine; HIV-1 infection; Prognostic marker; RT mutations
antiretrovirus agent; rna directed dna polymerase; zidovudine; article; child; clinical article; female; gene mutation; human; human immunodeficiency virus 1; human immunodeficiency virus infection; infant; male; nonhuman; nucleotide sequence; priority journal; prognosis; virus gene; Anti-HIV Agents; Child; Child, Preschool; Codon; Cohort Studies; Disease Progression; Female; HIV Infections; HIV-1; HIV-1 Reverse Transcriptase; Humans; Infant; Male; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Variation (Genetics); Zidovudine; Human immunodeficiency virus; Human immunodeficiency virus 1; RNA viruses
Orlandi, P., Cancrini, C., Scaccia, S., Romiti, M.l., Livadiotti, S., Gattinara, G.c., et al. (1998). Analysis of HIV-1 reverse transcriptase gene mutations in infected children treated with zidovudine. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 19(3), 230-237.
Orlandi, P; Cancrini, C; Scaccia, S; Romiti, Ml; Livadiotti, S; Gattinara, Gc; Angelini, F; Cox, S; Rossi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/57594
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