A lowering effect of folate supplementation on homocysteine levels (tHcy) in patients with type 2 diabetes mellitus (T2D) was recently demonstrated by Aghamohammadi V. and collaborators (1), but no data on T2D with chronic kidney disease (CKD) were reported. Aim: Aim of the study is to determine tHcy levels in T2D patients at various stages of CKD, and the relationship with folate and vitamin B12. Methods: We recruited 40 T2D-CKD patients (stages II-IV according to K-DOKI guidelines). tHcy levels were measured as previous decribed (2). Folate and vitamin B12 were assayed by an automated chemiluminescence system (Advia Centaur; Siemens). Results: tHcy levels increases in all patients, and this rise positively correlate with the CKD stage (p<0.05). Moreover, we interestingly found that only in stage 2 CKD tHcy concentrations negatively correlates with low levels of both vitamin B12 and folate, whereas in stage 3 folate have no effect, and in stage 4 vitamin B12 have no effect on tHcy concentrations. Conclusion: We demonstrated for the first time that tHcy increase in diabetic CKD patients and this rise correlate positively with the stage of kidney disease. Folate and vitamin B12 levels have different effect on tHcy levels at different stages of CKD. These results may indicate the importance of the combined folate and vitamin B12 therapy at early stage of CKD, where the levels of tHcy negatively correlates with both folate and vitamin B12.

Noce, A., Pastore, A., Di Giovamberardino, G., Di Stefano, A., DI DANIELE, N., Cinzia, C., et al. (2012). Homocysteine, folate and vitamin B12 levels in type 2 diabetic patiens with various stage of chronic kidney disease. In Clinical chemistry and laboratory medicine.

Homocysteine, folate and vitamin B12 levels in type 2 diabetic patiens with various stage of chronic kidney disease

Noce, A;DI DANIELE, NICOLA;DESSI', MARIARITA
2012-03-01

Abstract

A lowering effect of folate supplementation on homocysteine levels (tHcy) in patients with type 2 diabetes mellitus (T2D) was recently demonstrated by Aghamohammadi V. and collaborators (1), but no data on T2D with chronic kidney disease (CKD) were reported. Aim: Aim of the study is to determine tHcy levels in T2D patients at various stages of CKD, and the relationship with folate and vitamin B12. Methods: We recruited 40 T2D-CKD patients (stages II-IV according to K-DOKI guidelines). tHcy levels were measured as previous decribed (2). Folate and vitamin B12 were assayed by an automated chemiluminescence system (Advia Centaur; Siemens). Results: tHcy levels increases in all patients, and this rise positively correlate with the CKD stage (p<0.05). Moreover, we interestingly found that only in stage 2 CKD tHcy concentrations negatively correlates with low levels of both vitamin B12 and folate, whereas in stage 3 folate have no effect, and in stage 4 vitamin B12 have no effect on tHcy concentrations. Conclusion: We demonstrated for the first time that tHcy increase in diabetic CKD patients and this rise correlate positively with the stage of kidney disease. Folate and vitamin B12 levels have different effect on tHcy levels at different stages of CKD. These results may indicate the importance of the combined folate and vitamin B12 therapy at early stage of CKD, where the levels of tHcy negatively correlates with both folate and vitamin B12.
Advances and Controversies in B-Vitamins and Choline
Lipsia (Germany)
2012
Rilevanza internazionale
mar-2012
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
English
folate; vitamin B12; homocisteyne; cronic kidney disease
Intervento a convegno
Noce, A., Pastore, A., Di Giovamberardino, G., Di Stefano, A., DI DANIELE, N., Cinzia, C., et al. (2012). Homocysteine, folate and vitamin B12 levels in type 2 diabetic patiens with various stage of chronic kidney disease. In Clinical chemistry and laboratory medicine.
Noce, A; Pastore, A; Di Giovamberardino, G; Di Stefano, A; DI DANIELE, N; Cinzia, C; Dessi', M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55465
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