Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism. They act as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as the insulin receptor, and a complex network of intracellular signalling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. In addition, differential IRS tissue- and developmental-specific expression patterns may contribute to specificity in their signaling potential. Copyright ┬® 2000 John Wiley & Sons, Ltd.

Giovannone, B., Scaldaferri, M., Federici, M., Porzio, O., Lauro, D., Fusco, A., et al. (2000). Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential. DIABETES/METABOLISM RESEARCH AND REVIEWS, 16(6), 434-441 [10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8].

Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential

FEDERICI, MASSIMO;PORZIO, OTTAVIA;LAURO, DAVIDE;FUSCO, ANGELO;SBRACCIA, PAOLO;BORBONI, PATRIZIA;LAURO, RENATO;SESTI, GIORGIO
2000

Abstract

Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism. They act as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as the insulin receptor, and a complex network of intracellular signalling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. In addition, differential IRS tissue- and developmental-specific expression patterns may contribute to specificity in their signaling potential. Copyright ┬® 2000 John Wiley & Sons, Ltd.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - Medicina Interna
eng
Con Impact Factor ISI
Insulin receptor substrate; Insulin signaling; IRS-1; IRS-2; IRS-3; IRS-4
Giovannone, B., Scaldaferri, M., Federici, M., Porzio, O., Lauro, D., Fusco, A., et al. (2000). Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential. DIABETES/METABOLISM RESEARCH AND REVIEWS, 16(6), 434-441 [10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8].
Giovannone, B; Scaldaferri, M; Federici, M; Porzio, O; Lauro, D; Fusco, A; Sbraccia, P; Borboni, P; Lauro, R; Sesti, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/53041
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