Hyperglycemia impairs functional properties of cytosolic and nuclear proteins via O-linked glycosylation modification (O-GlcNAcylation). We studied the effects of O-GlcNAcylation on insulin signaling in human coronary artery endothelial cells.

Federici, M., Menghini, R., Mauriello, A., Hribal, M., Ferrelli, F., Lauro, D., et al. (2002). Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells. CIRCULATION, 106(4), 466-472 [10.1161/​01.CIR.0000023043.02648.51].

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

FEDERICI, MASSIMO;MENGHINI, ROSSELLA;MAURIELLO, ALESSANDRO;LAURO, DAVIDE;SBRACCIA, PAOLO;SESTI, GIORGIO;LAURO, RENATO
2002-07-23

Abstract

Hyperglycemia impairs functional properties of cytosolic and nuclear proteins via O-linked glycosylation modification (O-GlcNAcylation). We studied the effects of O-GlcNAcylation on insulin signaling in human coronary artery endothelial cells.
23-lug-2002
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
Settore MED/13 - ENDOCRINOLOGIA
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
Settore MED/50 - SCIENZE TECNICHE MEDICHE APPLICATE
English
Con Impact Factor ISI
Insulin Antagonists; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Activation; Glucosamine; Humans; Glucose; Arteriosclerosis; Glycosylation; Endothelium, Vascular; Insulin; Tissue Inhibitor of Metalloproteinase-3; Nitric Oxide Synthase Type III; Nitric Oxide Synthase; Matrix Metalloproteinases; Phosphorylation; Cells, Cultured; Proteins; Signal Transduction; Diabetes Complications
Federici, M., Menghini, R., Mauriello, A., Hribal, M., Ferrelli, F., Lauro, D., et al. (2002). Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells. CIRCULATION, 106(4), 466-472 [10.1161/​01.CIR.0000023043.02648.51].
Federici, M; Menghini, R; Mauriello, A; Hribal, M; Ferrelli, F; Lauro, D; Sbraccia, P; Spagnoli, L; Sesti, G; Lauro, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/52897
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