Background: A deletion of 32 base pairs in the CCR5 gene (Delta 32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults. Materials and Methods: To determine the role of Delta 32 CCR5 in disease progression of HIV-1 infected children born to seropositive mothers, we studied a polymerase chain reaction in 301 HIV-1 infected, 262 HIV-1 exposed-uninfected and 47 HIV-1 unexposed-uninfected children of Spanish and Italian origin. Infected children were further divided into two groups according to their rate of HIV-1 disease progression: rapid progressors who developed severe clinical and/or immunological conditions within the second year of life, and delayed progressors with any other evolution of disease. Among the latter were the long-term, non-progressors (LTNP) who presented with mild or no symptoms of HIV-1 infection above 8 years of age. Viral phenotype was studied for 45 delayed progressors. Results: No correlation was found between Delta 32 CCR5 and mother-to-child transmission of HIV-1. However, the frequency of the deletion was substantially higher in LTNP, compared with delayed (p = 0.019) and rapid progressors (p = 0.0003). In children carrying the Delta 32 CCR5 mutation, the presence of MT-2 tropic virus isolate was associated with a severe immune suppression (p = 0.028); whereas, the presence of MT-2 negative viruses correlated with LTNP (p = 0.010). Conclusions: Given the rapidity and simplicity of the assay, the Delta 32 CCR5 mutation may be a useful predictive marker to identify children with delayed disease progression who, consequently, may not require immediate antiretroviral treatment.

Romiti, M.l., Colognesi, C., Cancrini, C., Mas, A., Berrino, M., Salvatori, F., et al. (2000). Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection. MOLECULAR MEDICINE, 6(1), 28-36.

Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection

ROMITI, MARIA LUISA;CANCRINI, CATERINA;ROSSI, PAOLO;
2000-01-01

Abstract

Background: A deletion of 32 base pairs in the CCR5 gene (Delta 32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults. Materials and Methods: To determine the role of Delta 32 CCR5 in disease progression of HIV-1 infected children born to seropositive mothers, we studied a polymerase chain reaction in 301 HIV-1 infected, 262 HIV-1 exposed-uninfected and 47 HIV-1 unexposed-uninfected children of Spanish and Italian origin. Infected children were further divided into two groups according to their rate of HIV-1 disease progression: rapid progressors who developed severe clinical and/or immunological conditions within the second year of life, and delayed progressors with any other evolution of disease. Among the latter were the long-term, non-progressors (LTNP) who presented with mild or no symptoms of HIV-1 infection above 8 years of age. Viral phenotype was studied for 45 delayed progressors. Results: No correlation was found between Delta 32 CCR5 and mother-to-child transmission of HIV-1. However, the frequency of the deletion was substantially higher in LTNP, compared with delayed (p = 0.019) and rapid progressors (p = 0.0003). In children carrying the Delta 32 CCR5 mutation, the presence of MT-2 tropic virus isolate was associated with a severe immune suppression (p = 0.028); whereas, the presence of MT-2 negative viruses correlated with LTNP (p = 0.010). Conclusions: Given the rapidity and simplicity of the assay, the Delta 32 CCR5 mutation may be a useful predictive marker to identify children with delayed disease progression who, consequently, may not require immediate antiretroviral treatment.
1-gen-2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Con Impact Factor ISI
chemokine receptor CCR5; adolescent; allele; article; child; disease transmission; gene deletion; genetics; human; Human immunodeficiency virus 1; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; infant; leukemia cell line; macrophage; mutation; newborn; phenotype; prediction and forecasting; preschool child; prognosis; virology; Adolescent; Alleles; Child; Child, Preschool; Disease Transmission, Vertical; HIV Infections; HIV Long-Term Survivors; HIV-1; Humans; Infant; Infant, Newborn; Jurkat Cells; Macrophages; Mutation; Phenotype; Predictive Value of Tests; Prognosis; Receptors, CCR5; Sequence Deletion
Romiti, M.l., Colognesi, C., Cancrini, C., Mas, A., Berrino, M., Salvatori, F., et al. (2000). Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection. MOLECULAR MEDICINE, 6(1), 28-36.
Romiti, Ml; Colognesi, C; Cancrini, C; Mas, A; Berrino, M; Salvatori, F; Orlandi, P; Jansson, M; Palomba, E; Plebani, A; Bertran, Jm; Hernandez, M; de...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51709
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