Background: A deletion of 32 base pairs in the CCR5 gene (Delta 32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults. Materials and Methods: To determine the role of Delta 32 CCR5 in disease progression of HIV-1 infected children born to seropositive mothers, we studied a polymerase chain reaction in 301 HIV-1 infected, 262 HIV-1 exposed-uninfected and 47 HIV-1 unexposed-uninfected children of Spanish and Italian origin. Infected children were further divided into two groups according to their rate of HIV-1 disease progression: rapid progressors who developed severe clinical and/or immunological conditions within the second year of life, and delayed progressors with any other evolution of disease. Among the latter were the long-term, non-progressors (LTNP) who presented with mild or no symptoms of HIV-1 infection above 8 years of age. Viral phenotype was studied for 45 delayed progressors. Results: No correlation was found between Delta 32 CCR5 and mother-to-child transmission of HIV-1. However, the frequency of the deletion was substantially higher in LTNP, compared with delayed (p = 0.019) and rapid progressors (p = 0.0003). In children carrying the Delta 32 CCR5 mutation, the presence of MT-2 tropic virus isolate was associated with a severe immune suppression (p = 0.028); whereas, the presence of MT-2 negative viruses correlated with LTNP (p = 0.010). Conclusions: Given the rapidity and simplicity of the assay, the Delta 32 CCR5 mutation may be a useful predictive marker to identify children with delayed disease progression who, consequently, may not require immediate antiretroviral treatment.
Romiti M.L., Colognesi C., Cancrini C., Mas A., Berrino M., Salvatori F., et al. (2000). Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection. MOLECULAR MEDICINE, 6(1), 28-36.
|Tipologia:||Articolo su rivista|
|Citazione:||Romiti M.L., Colognesi C., Cancrini C., Mas A., Berrino M., Salvatori F., et al. (2000). Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection. MOLECULAR MEDICINE, 6(1), 28-36.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||1-gen-2000|
|Titolo:||Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection|
|Autori:||Romiti M.L.; Colognesi C.; Cancrini C.; Mas A.; Berrino M.; Salvatori F.; Orlandi P.; Jansson M.; Palomba E.; Plebani A.; Bertran J.M.; Hernandez M.; de Martino M., Amoroso A.; Tovo P.A.; Rossi P.; Espanol T.; Scarlatti G.|
|Appare nelle tipologie:||01 - Articolo su rivista|