Protein kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain areas after treatment with alpha-glycerylphosphorylcholine (GPC), a cognition-enhancing drug which promotes acetylcholine synthesis and release. The drug induced both in vivo and in vitro PKC translocation. In vivo, an increase of particulate PKC activity was observed 1 hour following the acute oral administration of a behaviorally active dose (600 mg/kg); the effect was transient. In vitro, GPC promoted PKC translocation in cortical slices at concentrations as low as 50 nM; the concentration-response curve was bell shaped. The increased PKC activity may be related to the cortical effects of GPC.
Govoni, S., Battaini, F.m., Lucchi, L., Pascale, A., Trabucchi, M.m. (1993). PKC TRANSLOCATION IN RAT-BRAIN CORTEX IS PROMOTED IN-VIVO AND IN-VITRO BY ALPHA-GLYCERYLPHOSPHORYLCHOLINE, A COGNITION-ENHANCING DRUG. In ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION (pp.307-310). NEW YORK : NEW YORK ACAD SCIENCES.
PKC TRANSLOCATION IN RAT-BRAIN CORTEX IS PROMOTED IN-VIVO AND IN-VITRO BY ALPHA-GLYCERYLPHOSPHORYLCHOLINE, A COGNITION-ENHANCING DRUG
BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1993-01-01
Abstract
Protein kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain areas after treatment with alpha-glycerylphosphorylcholine (GPC), a cognition-enhancing drug which promotes acetylcholine synthesis and release. The drug induced both in vivo and in vitro PKC translocation. In vivo, an increase of particulate PKC activity was observed 1 hour following the acute oral administration of a behaviorally active dose (600 mg/kg); the effect was transient. In vitro, GPC promoted PKC translocation in cortical slices at concentrations as low as 50 nM; the concentration-response curve was bell shaped. The increased PKC activity may be related to the cortical effects of GPC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
