The levels of the neuroactive steroids allopregnanolone (THP) and 5α-dihydroprogesterone (DHP) were quantified in the plasma of 11 (group 1) and in the liquor of 12 (group 2) Parkinson's disease (PD) patients using a gas-chromatographic/mass-spectrometric method. When compared with controls, both groups showed a significant decrease in DHP and THP concentrations. These decreases could be a useful marker of PD. Moreover, in view of the importance of GABA-ergic transmission to substantia nigra (SN) neurons and GABA-ergic modulation exerted by the two neuroactive steroids, our data indicate a global dysregulation of the SN GABA-ergic system in PD patients. Moreover, a lack of neuroprotective factors (i.e., GDNF, BDNF), promoted by DHP, may contribute to dopaminergic cell death.

di Michele, F., Longone, P., Romeo, E., Lucchetti, S., Brusa, L., Pierantozzi, M., et al. (2003). Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease. In Neurological Sciences (pp.172-173) [10.1007/s10072-003-0115-1].

Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease

PIERANTOZZI, MARIANGELA;BERNARDI, GIORGIO;STANZIONE, PAOLO
2003

Abstract

The levels of the neuroactive steroids allopregnanolone (THP) and 5α-dihydroprogesterone (DHP) were quantified in the plasma of 11 (group 1) and in the liquor of 12 (group 2) Parkinson's disease (PD) patients using a gas-chromatographic/mass-spectrometric method. When compared with controls, both groups showed a significant decrease in DHP and THP concentrations. These decreases could be a useful marker of PD. Moreover, in view of the importance of GABA-ergic transmission to substantia nigra (SN) neurons and GABA-ergic modulation exerted by the two neuroactive steroids, our data indicate a global dysregulation of the SN GABA-ergic system in PD patients. Moreover, a lack of neuroprotective factors (i.e., GDNF, BDNF), promoted by DHP, may contribute to dopaminergic cell death.
29th National Congress on Parkinson Parkinsonism Dementia
LECCE, ITALY
OCT 23-25, 2002
Rilevanza internazionale
su invito
Settore BIO/09
Settore MED/39 - Neuropsichiatria Infantile
English
3alpha hydroxy 5alpha pregnan 20 one; biological marker; brain derived neurotrophic factor; dydrogesterone; glial cell line derived neurotrophic factor; progesterone; steroid; adult; aged; article; brain dysfunction; cell death; cerebrospinal fluid analysis; clinical article; GABAergic system; gas chromatography; hormone action; human; mass spectrometry; neuroprotection; Parkinson disease; protein function; steroid blood level; substantia nigra; Aged; Analysis of Variance; Brain Chemistry; Case-Control Studies; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Parkinson Disease; Pilot Projects; Steroids
Intervento a convegno
di Michele, F., Longone, P., Romeo, E., Lucchetti, S., Brusa, L., Pierantozzi, M., et al. (2003). Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease. In Neurological Sciences (pp.172-173) [10.1007/s10072-003-0115-1].
di Michele, F; Longone, P; Romeo, E; Lucchetti, S; Brusa, L; Pierantozzi, M; Bassi, A; Bernardi, G; Stanzione, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/49956
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