T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.

Caruso, R., Botti, E., Sarra, M., Esposito, M., Stolfi, C., Diluvio, L., et al. (2009). Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. NATURE MEDICINE, 15(9), 1013-1015 [10.1038/nm.1995].

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Botti, E;Stolfi, C;Campione, E;CHIMENTI, SERGIO;PALLONE, FRANCESCO;COSTANZO, ANTONIO;MONTELEONE, GIOVANNI
2009-01-01

Abstract

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
Con Impact Factor ISI
INFLAMMATION
Caruso, R., Botti, E., Sarra, M., Esposito, M., Stolfi, C., Diluvio, L., et al. (2009). Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. NATURE MEDICINE, 15(9), 1013-1015 [10.1038/nm.1995].
Caruso, R; Botti, E; Sarra, M; Esposito, M; Stolfi, C; Diluvio, L; Giustizieri, M; Pacciani, V; Mazzotta, A; Campione, E; Macdonald, T; Chimenti, S; Pallone, F; Costanzo, A; Monteleone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/48627
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