DRP1-dependent mitochondrial fission is crucial in orchestrating processes determining T cell efficiency and life, as well as an efficient immune-surveillance. In this scenario, we showed how PD1-dependent exhaustion on T cells affects mitochondrial fragmentation through DRP1 inhibition, so downregulating T cell anti-tumoral activity in solid tumor microenvironment. We are dissecting new molecular mechanisms and targets, with the aim of therapeutically improve T cell tumoral defense. [work supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE00000012)]
Campello, S. (2025). T lymphocyte mitochondrial fragmentation in solid tumor immune-surveillance. ??????? it.cilea.surplus.oa.citation.tipologie.CitationProceedings.prensentedAt ??????? Cold Spring Harbor Conferences Asia in “Mitochondria and metabolism in health and disease”.
T lymphocyte mitochondrial fragmentation in solid tumor immune-surveillance
Campello S
Conceptualization
2025-01-01
Abstract
DRP1-dependent mitochondrial fission is crucial in orchestrating processes determining T cell efficiency and life, as well as an efficient immune-surveillance. In this scenario, we showed how PD1-dependent exhaustion on T cells affects mitochondrial fragmentation through DRP1 inhibition, so downregulating T cell anti-tumoral activity in solid tumor microenvironment. We are dissecting new molecular mechanisms and targets, with the aim of therapeutically improve T cell tumoral defense. [work supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE00000012)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
