A girl with celiac disease and KCNJ11 mutation was transferred to glibenclamide when 19.8 years old. When her compliance to the gluten free diet worsened, her metabolic control deteriorated. Since glibenclamide is absorbed in the intestine, its absorption seems to be impaired by chronic malabsorption, increasing the risk of hyperglycaemia. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Delvecchio, M., Zecchino, C., Faienza, M.f., Acquafredda, A., Barbetti, F., Cavallo, L. (2009). Sulfonylurea treatment in a girl with neonatal diabetes (KCNJ11 R201H) and celiac disease: Impact of low compliance to the gluten free diet. DIABETES RESEARCH AND CLINICAL PRACTICE, 84(3), 332-334 [10.1016/j.diabres.2009.02.024].

Sulfonylurea treatment in a girl with neonatal diabetes (KCNJ11 R201H) and celiac disease: Impact of low compliance to the gluten free diet

BARBETTI, FABRIZIO;
2009-01-01

Abstract

A girl with celiac disease and KCNJ11 mutation was transferred to glibenclamide when 19.8 years old. When her compliance to the gluten free diet worsened, her metabolic control deteriorated. Since glibenclamide is absorbed in the intestine, its absorption seems to be impaired by chronic malabsorption, increasing the risk of hyperglycaemia. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - ENDOCRINOLOGIA
English
Celiac disease; Gluten free diet; KCNJ11; Neonatal diabetes; Sulfonylurea
glibenclamide; glucose; hemoglobin A1c; insulin derivative; inwardly rectifying potassium channel subunit Kir6.2; sulfonylurea; adult; article; case report; celiac disease; drug absorption; drug dose increase; female; gene mutation; glucose blood level; gluten free diet; hemoglobin blood level; human; human tissue; hyperglycemia; insulin treatment; juvenile diabetes mellitus; oral glucose tolerance test; patient compliance; Amino Acid Substitution; Autoantibodies; Diabetes Mellitus; Diet, Gluten-Free; Female; Glyburide; Hemoglobin A, Glycosylated; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Intestinal Absorption; Patient Compliance; Potassium Channels, Inwardly Rectifying; Sulfonylurea Compounds; Transglutaminases; Young Adult
Delvecchio, M., Zecchino, C., Faienza, M.f., Acquafredda, A., Barbetti, F., Cavallo, L. (2009). Sulfonylurea treatment in a girl with neonatal diabetes (KCNJ11 R201H) and celiac disease: Impact of low compliance to the gluten free diet. DIABETES RESEARCH AND CLINICAL PRACTICE, 84(3), 332-334 [10.1016/j.diabres.2009.02.024].
Delvecchio, M; Zecchino, C; Faienza, Mf; Acquafredda, A; Barbetti, F; Cavallo, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/44817
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