Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.

Gliozzi, M., Macri', R., Rita Coppoletta, A., Musolino, V., Carresi, C., Scicchitano, M., et al. (2022). From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts. NUTRIENTS, 14(18) [10.3390/nu14183737].

From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts

Micaela Gliozzi;Rocco Mollace;vincenzo mollace
2022-01-01

Abstract

Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.
2022
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MEDS-07/B - Malattie dell'apparato cardiovascolare
Settore MEDS-05/A - Medicina interna
English
Con Impact Factor ISI
SGLT2 inhibitors
cardiovascular risk
diabetes
inflammation
insulin resistance
lipid accumulation
nutraceutical supplementation
reactive oxygen species (ROS)
Gliozzi, M., Macri', R., Rita Coppoletta, A., Musolino, V., Carresi, C., Scicchitano, M., et al. (2022). From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts. NUTRIENTS, 14(18) [10.3390/nu14183737].
Gliozzi, M; Macri', R; Rita Coppoletta, A; Musolino, V; Carresi, C; Scicchitano, M; Bosco, F; Guarnieri, L; Cardamone, A; Ruga, S; Scarano, F; Nucera,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/437903
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