T-helper (Th)1 cells play a central role in the pathogenesis of tissue damage in Crohn's disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell commitment in CD, but other cytokines are needed to maintain activated Th1 cells in the mucosa. In this study, we examined the expression and role of IL-21, a T-cell-derived cytokine of the IL-2 family; in tissues and cells isolated from patients with inflammatory bowel disease.
Monteleone, G., Monteleone, I., Fina, D., Vavassori, P., DEL VECCHIO BLANCO, G., Caruso, R., et al. (2005). Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. GASTROENTEROLOGY, 128(3), 687-694 [10.1053/j.gastro.2004.12.042].
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
MONTELEONE, GIOVANNI;MONTELEONE, IVAN;DEL VECCHIO BLANCO, GIOVANNA;CARUSO, ROBERTA;BIANCONE, LIVIA;PALLONE, FRANCESCO
2005-03-01
Abstract
T-helper (Th)1 cells play a central role in the pathogenesis of tissue damage in Crohn's disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell commitment in CD, but other cytokines are needed to maintain activated Th1 cells in the mucosa. In this study, we examined the expression and role of IL-21, a T-cell-derived cytokine of the IL-2 family; in tissues and cells isolated from patients with inflammatory bowel disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
