T-helper (Th)1 cells play a central role in the pathogenesis of tissue damage in Crohn's disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell commitment in CD, but other cytokines are needed to maintain activated Th1 cells in the mucosa. In this study, we examined the expression and role of IL-21, a T-cell-derived cytokine of the IL-2 family; in tissues and cells isolated from patients with inflammatory bowel disease.

Monteleone, G., Monteleone, I., Fina, D., Vavassori, P., DEL VECCHIO BLANCO, G., Caruso, R., et al. (2005). Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease, 128(3), 687-694 [10.1053/j.gastro.2004.12.042].

Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

MONTELEONE, GIOVANNI;MONTELEONE, IVAN;DEL VECCHIO BLANCO, GIOVANNA;CARUSO, ROBERTA;BIANCONE, LIVIA;PALLONE, FRANCESCO
2005-03-01

Abstract

T-helper (Th)1 cells play a central role in the pathogenesis of tissue damage in Crohn's disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell commitment in CD, but other cytokines are needed to maintain activated Th1 cells in the mucosa. In this study, we examined the expression and role of IL-21, a T-cell-derived cytokine of the IL-2 family; in tissues and cells isolated from patients with inflammatory bowel disease.
mar-2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Interferon-gamma; Interleukin-12; Recombinant Proteins; Humans; Interleukins; Colitis, Ulcerative; Blotting, Western; Cells, Cultured; Crohn Disease; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Signal Transduction; Th1 Cells
Monteleone, G., Monteleone, I., Fina, D., Vavassori, P., DEL VECCHIO BLANCO, G., Caruso, R., et al. (2005). Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease, 128(3), 687-694 [10.1053/j.gastro.2004.12.042].
Monteleone, G; Monteleone, I; Fina, D; Vavassori, P; DEL VECCHIO BLANCO, G; Caruso, R; Tersigni, R; Alessandroni, L; Biancone, L; Naccari, G; Macdonald, T; Pallone, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/42147
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