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EnglishType 2 diabetes is the most common form of diabetes in humans. It results from a combination of factors that impair beta-cell function and tissue insulin sensitivity. However, growing evidence is showing that the beta-cell is central to the development and progression of this form of diabetes. Reduced islet and/or insulin-containing cell mass or volume in Type 2 diabetes has been reported by several authors. Furthermore, studies with isolated Type 2 diabetic islets have consistently shown both quantitative and qualitative defects of glucose-stimulated insulin secretion. The impact of genotype in affecting beta-cell function and survival is a very fast growing field or research, and several gene polymorphisms have been associated with this form of diabetes. Among acquired factors, glucotoxicity, lipotoxicity and altered IAPP processing are likely to play an important role. Interestingly, however, pharmacological intervention can improve several defects of Type 2 diabetes islet cells in vitro, suggesting that progression of the disease might not be relentless.
| Tipologia: | Articolo su rivista |
| Citazione: | Marchetti, P., Dotta, F., Lauro, D., & Purrello, F. (2008). An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment. REGULATORY PEPTIDES, 146(1-3), 4-11. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/13 - Endocrinologia Settore MED/09 - Medicina Interna Settore MED/50 - Scienze Tecniche Mediche Applicate |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.regpep.2007.08.017 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 7-feb-2008 |
| Titolo: | An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment |
| Autori: | |
| Autori: | Marchetti, P; Dotta, F; Lauro, D; Purrello, F |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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