graphs are a natural representation of brain activity derived from functional magnetic imaging (fMRI) data. It is well known that clusters of anatomical brain regions, known as functional connectivity networks (FCNs), encode temporal relationships which can serve as useful biomarkers for understanding brain function and dysfunction. previous works, however, ignore the temporal dynamics of the brain and focus on static graphs. In this paper, we propose a dynamic brain graph deep generative model (DBGDGM) which simultaneously clusters brain regions into temporally evolving communities and learns dynamic unsupervised node embeddings. specifically, DBGDGM represents brain graph nodes as embeddings sampled from a distribution over communities that evolve over time. we parameterise this community distribution using neural networks that learn from subject and node embeddings as well as past community assignments. experiments demonstrate DBGDGM outperforms baselines in graph generation, dynamic link prediction, and is comparable for graph classification. finally, an analysis of the learnt community distributions reveals overlap with known FCNs reported in neuroscience literature. code available at https://github.com/simeon-spasov/dynamic-brain-graph-deep-generative-model.

Campbell, A., Spasov, S., Toschi, N., Lio, P. (2023). DBGDGM: Dynamic Brain Graph Deep Generative Model. In MEDICAL IMAGING WITH DEEP LEARNING (pp.1346-1371). ML Research Press.

DBGDGM: Dynamic Brain Graph Deep Generative Model

Toschi N.;
2023-01-01

Abstract

graphs are a natural representation of brain activity derived from functional magnetic imaging (fMRI) data. It is well known that clusters of anatomical brain regions, known as functional connectivity networks (FCNs), encode temporal relationships which can serve as useful biomarkers for understanding brain function and dysfunction. previous works, however, ignore the temporal dynamics of the brain and focus on static graphs. In this paper, we propose a dynamic brain graph deep generative model (DBGDGM) which simultaneously clusters brain regions into temporally evolving communities and learns dynamic unsupervised node embeddings. specifically, DBGDGM represents brain graph nodes as embeddings sampled from a distribution over communities that evolve over time. we parameterise this community distribution using neural networks that learn from subject and node embeddings as well as past community assignments. experiments demonstrate DBGDGM outperforms baselines in graph generation, dynamic link prediction, and is comparable for graph classification. finally, an analysis of the learnt community distributions reveals overlap with known FCNs reported in neuroscience literature. code available at https://github.com/simeon-spasov/dynamic-brain-graph-deep-generative-model.
6th International Conference on Medical Imaging with Deep Learning (MIDL)
Nashville, TN (USA)
2023
6.
Rilevanza internazionale
contributo
2023
Settore PHYS-06/B - Didattica e storia della fisica
English
Dynamic graph
functional magnetic resonance imaging
generative model
This work is supported by The Alan Turing Institute under the EPSRC grant EP/N510129/1. Data were provided [in part] by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. The UK Biobank data (application 20904) were curated and analyzed using a computational facility funded by an MRC research infrastructure award (MR/M009041/1) and supported by the NIHR Cambridge Biomedical Research Centre and a Marmaduke Shield Award to Dr. Richard A.I. Bethlehem and Varun Warrier. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Intervento a convegno
Campbell, A., Spasov, S., Toschi, N., Lio, P. (2023). DBGDGM: Dynamic Brain Graph Deep Generative Model. In MEDICAL IMAGING WITH DEEP LEARNING (pp.1346-1371). ML Research Press.
Campbell, A; Spasov, S; Toschi, N; Lio, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/404323
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