We previously demonstrated that in inflammatory bowel disease (IBD) there is enhanced production of interleukin (IL)-21, a cytokine that activates multiple pathways that sustain mucosal inflammation. However, the phenotype of IL-21-producing cells in IBD, and the cytokine(s) they coproduce, is not known. We here characterized the cell source of IL-21 and determined which factors regulate IL-21 in the human gut.
Sarra, M., Monteleone, I., Stolfi, C., Fantini, M.c., Sileri, P., Sica, G., et al. (2010). Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. INFLAMMATORY BOWEL DISEASES, 16(8), 1332-1339 [10.1002/ibd.21238].
Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases
MONTELEONE, IVAN;Stolfi, C;FANTINI, MASSIMO CLAUDIO;SILERI, PIERPAOLO;SICA, GIUSEPPE;PALLONE, FRANCESCO;MONTELEONE, GIOVANNI
2010-08-01
Abstract
We previously demonstrated that in inflammatory bowel disease (IBD) there is enhanced production of interleukin (IL)-21, a cytokine that activates multiple pathways that sustain mucosal inflammation. However, the phenotype of IL-21-producing cells in IBD, and the cytokine(s) they coproduce, is not known. We here characterized the cell source of IL-21 and determined which factors regulate IL-21 in the human gut.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
