In the last decade, immunotherapy (IT) has revolutionized oncology and found indications in many cancers, including hepatocellular carcinoma (HCC). In HCC, IT has become the leading systemic therapy for advanced diseases. At the same time, it carries the promise of being a valuable therapy in other settings, including intermediate-stage and unresectable disease, as a downstaging or conversion modality. More controversial is the role of IT in relationship to liver transplantation (LT): on one side, it could be a helpful tool to control or downstage HCC before LT or to treat tumor recurrence after LT, while on the other, it carries the risk of graft rejection and graft loss. This review aims to cover these concerns in depth and unravel the current literature.

Sensi, B., Angelico, R., Toti, L., Conte, L., Coppola, A., Tisone, G., et al. (2024). Mechanism, potential, and concerns of immunotherapy for hepatocellular carcinoma and liver transplantation. CURRENT MOLECULAR PHARMACOLOGY, 17 [10.2174/0118761429310703240823045808].

Mechanism, potential, and concerns of immunotherapy for hepatocellular carcinoma and liver transplantation

Sensi, Bruno;Angelico, Roberta;Toti, Luca;Conte, Luigi;Tisone, Giuseppe;Manzia, Tommaso Maria
2024-01-01

Abstract

In the last decade, immunotherapy (IT) has revolutionized oncology and found indications in many cancers, including hepatocellular carcinoma (HCC). In HCC, IT has become the leading systemic therapy for advanced diseases. At the same time, it carries the promise of being a valuable therapy in other settings, including intermediate-stage and unresectable disease, as a downstaging or conversion modality. More controversial is the role of IT in relationship to liver transplantation (LT): on one side, it could be a helpful tool to control or downstage HCC before LT or to treat tumor recurrence after LT, while on the other, it carries the risk of graft rejection and graft loss. This review aims to cover these concerns in depth and unravel the current literature.
2024
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MEDS-06/A - Chirurgia generale
English
Downstaging
Hepatocellular carcinoma
Immune checkpoint
Immunotherapy
Liver transplantation
Sensi, B., Angelico, R., Toti, L., Conte, L., Coppola, A., Tisone, G., et al. (2024). Mechanism, potential, and concerns of immunotherapy for hepatocellular carcinoma and liver transplantation. CURRENT MOLECULAR PHARMACOLOGY, 17 [10.2174/0118761429310703240823045808].
Sensi, B; Angelico, R; Toti, L; Conte, L; Coppola, A; Tisone, G; Manzia, Tm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/395869
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