Background: We present a case of 72-year-old man with a history of metastatic melanoma diagnosed in 2015 presenting a stable disease in treatment with dabrafenib. Case Description: The patient had been surgically treated for a presumed intracranial parietooccipital metastasis. He presented 1 month later with a meningeal lesion associated with a subdural hematoma. A second surgical treatment confirmed the diagnosis of meningeal recurrence of metastatic melanoma. Conclusions: The most recent literature lacks studies defining the clinical phenomena of an early recurrence of intracranial melanoma with de novo involvement of dural compartment in patients in treatment with a target immunotherapy. The aim of this present study is to report a case of early recurrence of intracranial melanoma metastases with evidence of fast immunohistochemical and macroscopical mutation of pathologic elements, with an analysis of literature that shows the lack of well-described occurrences.
Armocida, D., Marzetti, F., Pesce, A., Caporlingua, A., D'Angelo, L., Santoro, A. (2020). Purely meningeal intracranial relapse of melanoma brain metastases after surgical resection and immunotherapy as a unique disease progression pattern: our experience and review of the literature. WORLD NEUROSURGERY, 134, 150-154 [10.1016/j.wneu.2019.10.101].
Purely meningeal intracranial relapse of melanoma brain metastases after surgical resection and immunotherapy as a unique disease progression pattern: our experience and review of the literature
Marzetti, Francesco;Pesce, Alessandro;D'Angelo, Luca;Santoro, Antonio
2020-01-01
Abstract
Background: We present a case of 72-year-old man with a history of metastatic melanoma diagnosed in 2015 presenting a stable disease in treatment with dabrafenib. Case Description: The patient had been surgically treated for a presumed intracranial parietooccipital metastasis. He presented 1 month later with a meningeal lesion associated with a subdural hematoma. A second surgical treatment confirmed the diagnosis of meningeal recurrence of metastatic melanoma. Conclusions: The most recent literature lacks studies defining the clinical phenomena of an early recurrence of intracranial melanoma with de novo involvement of dural compartment in patients in treatment with a target immunotherapy. The aim of this present study is to report a case of early recurrence of intracranial melanoma metastases with evidence of fast immunohistochemical and macroscopical mutation of pathologic elements, with an analysis of literature that shows the lack of well-described occurrences.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
