In healthy individuals, antigens from the gut lumen are tolerated by the mucosal immune system. However, a loss of tolerance toward the bacterial microflora probably causes inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis. The abnormal activation of the immune system in the gut of IBD patients is characterized by a cascade of cellular events orchestrated by cytokine cross talk between immune and non-immune cells. Interleukin (IL)-21, the newest member of the common Î³-chain-dependent cytokine family, is a key component of the inflammatory cascade in the gut. It is highly expressed in CD and sustains the ongoing T helper type 1 (Th1)-mediated immune response. IL-21 is essential for the differentiation of Th17 cells. IL-21 is also involved in recruiting T cells to the inflamed gut and eliciting the secretion of matrix-degrading enzymes by gut fibroblasts. Overall, there is now sufficient evidence to suggest that targeting IL-21 will be of therapeutic benefit in IBD.
Fantini M.C., M.G. (2008). IL-21 comes of age as a regulator of effector T cells in the gut. MUCOSAL IMMUNOLOGY, 1(2), 110-115.
|Tipologia:||Articolo su rivista|
|Citazione:||Fantini M.C., M.G. (2008). IL-21 comes of age as a regulator of effector T cells in the gut. MUCOSAL IMMUNOLOGY, 1(2), 110-115.|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/mi.2007.17|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2008|
|Titolo:||IL-21 comes of age as a regulator of effector T cells in the gut|
|Autori:||Fantini M.C., Monteleone G., MacDonald T.T.|
|Appare nelle tipologie:||01 - Articolo su rivista|