Crohn's disease (CD) and ulcerative colitis (UC) are caused by the over-activity of the immune system. Current and novel therapies are designed to dampen these over-active C responses.C responses. Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases. The former has the molecular imprints of a Th1 dominant cell-mediated hypersensitivity response whereas the latter appears to involve antibody-mediated hypersensitivity.

Macdonald, T.t., Monteleone, G. (2006). Overview of role of the immune system in the pathogenesis of inflammatory bowel disease, 579, 98-107 [10.1007/0-387-33778-4_6].

Overview of role of the immune system in the pathogenesis of inflammatory bowel disease

MONTELEONE, GIOVANNI
2006-01-01

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are caused by the over-activity of the immune system. Current and novel therapies are designed to dampen these over-active C responses.C responses. Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases. The former has the molecular imprints of a Th1 dominant cell-mediated hypersensitivity response whereas the latter appears to involve antibody-mediated hypersensitivity.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - Gastroenterologia
English
CHRONIC GRANULOMATOUS-DISEASE; GROWTH-FACTOR-BETA; CD4(+) T-CELLS; CROHNS-DISEASE; ULCERATIVE-COLITIS; MATRIX METALLOPROTEINASES; COLLAGENOUS COLITIS; TRANSCRIPTION FACTOR; SIGNAL-TRANSDUCTION; INTERFERON-GAMMA
Macdonald, T.t., Monteleone, G. (2006). Overview of role of the immune system in the pathogenesis of inflammatory bowel disease, 579, 98-107 [10.1007/0-387-33778-4_6].
Macdonald, Tt; Monteleone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/39225
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