The gut immune system has the challenge of responding to pathogens while remaining relatively unresponsive to food antigens and the commensal microflora. In the developed world, this ability appears to be breaking down, with chronic inflammatory diseases of the gut commonplace in the apparent absence of overt infections. In both mouse and man, mutations in genes that control innate immune recognition, adaptive immunity, and epithelial permeability are all associated with gut inflammation. This suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy.

MacDonald, T., & Monteleone, G. (2005). Immunity, inflammation, and allergy in the gut. SCIENCE, 307(5717), 1920-1925 [10.1126/science.1106442].

Immunity, inflammation, and allergy in the gut

MONTELEONE, GIOVANNI
2005

Abstract

The gut immune system has the challenge of responding to pathogens while remaining relatively unresponsive to food antigens and the commensal microflora. In the developed world, this ability appears to be breaking down, with chronic inflammatory diseases of the gut commonplace in the apparent absence of overt infections. In both mouse and man, mutations in genes that control innate immune recognition, adaptive immunity, and epithelial permeability are all associated with gut inflammation. This suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - Gastroenterologia
English
Allergies; Antigens; Diseases; Food products; Genes; Living systems studies; Epithelial permeability; Inflammation; Mutations; Pathogens; Immunology; food antigen; biology; allergy; antigen recognition; commensalism; enteritis; gene mutation; homeostasis; human; immunity; inflammation; innate immunity; intestine; intestine flora; microflora; priority journal; review; Animals; Antigens, Bacterial; Bacteria; Bacterial Physiology; Celiac Disease; Food Hypersensitivity; Gluten; Homeostasis; Humans; Immunity, Mucosal; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Mutation; Permeability; T-Lymphocytes
MacDonald, T., & Monteleone, G. (2005). Immunity, inflammation, and allergy in the gut. SCIENCE, 307(5717), 1920-1925 [10.1126/science.1106442].
Macdonald, Tt; Monteleone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/39215
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