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EnglishOsteoarthritis is a progressive joint disease characterized by cartilage degradation and bone remodeling. Transglutaminases catalyze a calcium-dependent transamidation reaction that produces covalent cross-linking of available substrate glutamine residues and modifies the extracellular matrix. Increased transglutaminases-mediated activity is reported in osteoarthritis, but the relative contribution of transglutaminases-2 (TG2) is uncertain. We describe TG2 expression in human femoral osteoarthritis and in wild-type and homozygous TG2 knockout mice after surgically-induced knee joint instability. Increased TG2 levels were observed in human and wild-type murine osteoarthritic cartilage compared to the respective controls. Histomorphometrical but not X-ray investigation documented in osteoarthritic TG2 knockout mice reduced cartilage destruction and an increased osteophyte formation compared to wild-type mice. These differences were associated with increased TGF beta-1 expression. In addition to confirming its important role in osteoarthritis development, our results demonstrated that TG2 expression differently influences cartilage destruction and bone remodeling, suggesting new targeted TG2-related therapeutic strategies.
Orlandi, A., Oliva, F., Taurisano, G., Candi, E., Di Lascio, A., Melino, G., et al. (2009). Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis. In AMINO ACIDS (pp.755-763). new York : Springer.
| Autori: | ||
| Autori: | Orlandi, A; Oliva, F; Taurisano, G; Candi, E; Di Lascio, A; Melino, G; Spagnoli, LG; Tarantino, U | |
| Titolo: | Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis | |
| Nome del convegno: | 9th Conference on Transglutaminase and Protein Crosslinking | |
| Luogo del convegno: | Marrakesh, MONACO | |
| Anno del convegno: | SEP, 2007 | |
| Rilevanza: | Rilevanza internazionale | |
| Data di pubblicazione: | 2009 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00726-008-0129-3 | |
| Settore Scientifico Disciplinare: | Settore MED/08 - Anatomia Patologica | |
| Lingua: | English | |
| Altre informazioni significative: | 9 | |
| Tipologia: | Intervento a convegno | |
| Citazione: | Orlandi, A., Oliva, F., Taurisano, G., Candi, E., Di Lascio, A., Melino, G., et al. (2009). Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis. In AMINO ACIDS (pp.755-763). new York : Springer. | |
| Appare nelle tipologie: | 02 - Intervento a convegno |
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