nanomedicine could improve the treatment of diabetes by exploiting various therapeutic mechanisms through the use of suitable nanoformulations. for example, glucose-sensitive nanoparticles can release insulin in response to high glucose levels, mimicking the physiological release of insulin. oral nanoformulations for insulin uptake via the gut represent a long-sought alternative to subcutaneous injections, which cause pain, discomfort, and possible local infection. nanoparticles containing oligonucleotides can be used in gene therapy and cell therapy to stimulate insulin production in β-cells or β-like cells and modulate the responses of T1DM-associated immune cells. In contrast, viral vectors do not induce immunogenicity. Finally, in diabetic wound healing, local delivery of nanoformulations containing regenerative molecules can stimulate tissue repair and thus provide a valuable tool to treat this diabetic complication. here, we describe these different approaches to diabetes treatment with nanoformulations and their potential for clinical application.

Andreadi, A., Lodeserto, P., Todaro, F., Meloni, M., Romano, M., Minasi, A., et al. (2024). Nanomedicine in the Treatment of Diabetes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(13) [10.3390/ijms25137028].

Nanomedicine in the Treatment of Diabetes

Aikaterini Andreadi
;
Pietro Lodeserto;Federica Todaro;Marco Meloni;Maria Romano;Alessandro Minasi;Alfonso Bellia;Davide Lauro
2024-01-01

Abstract

nanomedicine could improve the treatment of diabetes by exploiting various therapeutic mechanisms through the use of suitable nanoformulations. for example, glucose-sensitive nanoparticles can release insulin in response to high glucose levels, mimicking the physiological release of insulin. oral nanoformulations for insulin uptake via the gut represent a long-sought alternative to subcutaneous injections, which cause pain, discomfort, and possible local infection. nanoparticles containing oligonucleotides can be used in gene therapy and cell therapy to stimulate insulin production in β-cells or β-like cells and modulate the responses of T1DM-associated immune cells. In contrast, viral vectors do not induce immunogenicity. Finally, in diabetic wound healing, local delivery of nanoformulations containing regenerative molecules can stimulate tissue repair and thus provide a valuable tool to treat this diabetic complication. here, we describe these different approaches to diabetes treatment with nanoformulations and their potential for clinical application.
2024
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/13
English
insulin pathway
nanomedicine
nanoparticles
oral formulation
type 1 diabetes mellitus
wound healing
Andreadi, A., Lodeserto, P., Todaro, F., Meloni, M., Romano, M., Minasi, A., et al. (2024). Nanomedicine in the Treatment of Diabetes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(13) [10.3390/ijms25137028].
Andreadi, A; Lodeserto, P; Todaro, F; Meloni, M; Romano, M; Minasi, A; Bellia, A; Lauro, D
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/382943
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact