Obesity-related inflammation is emerging as a major cause of insulin resistance and cardiovascular diseases. GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells. We hypothesized that GATA2 activity is controlled by insulin during adipogenesis, linking metabolic homeostasis and inflammation.

Menghini, R., Marchetti, V., Cardellini, M., Hribal, M., Mauriello, A., Lauro, D., et al. (2005). Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. CIRCULATION, 111(15), 1946-1953 [10.1161/01.CIR.0000161814.02942.B2].

Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis

MENGHINI, ROSSELLA;CARDELLINI, MARINA;MAURIELLO, ALESSANDRO;LAURO, DAVIDE;SBRACCIA, PAOLO;LAURO, RENATO;FEDERICI, MASSIMO
2005-04-19

Abstract

Obesity-related inflammation is emerging as a major cause of insulin resistance and cardiovascular diseases. GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells. We hypothesized that GATA2 activity is controlled by insulin during adipogenesis, linking metabolic homeostasis and inflammation.
19-apr-2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - ANATOMIA PATOLOGICA
English
Con Impact Factor ISI
Active Transport, Cell Nucleus; Obesity; DNA-Binding Proteins; Humans; Proto-Oncogene Proteins c-akt; Cell Differentiation; Arteriosclerosis; GATA2 Transcription Factor; Protein-Serine-Threonine Kinases; Adipose Tissue; Insulin; Phosphatidylinositol 3-Kinases; Inflammation; Proto-Oncogene Proteins; Transcription Factors; Phosphoproteins; Phosphorylation; Signal Transduction
Menghini, R., Marchetti, V., Cardellini, M., Hribal, M., Mauriello, A., Lauro, D., et al. (2005). Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. CIRCULATION, 111(15), 1946-1953 [10.1161/01.CIR.0000161814.02942.B2].
Menghini, R; Marchetti, V; Cardellini, M; Hribal, M; Mauriello, A; Lauro, D; Sbraccia, P; Lauro, R; Federici, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/36965
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