Obesity-related inflammation is emerging as a major cause of insulin resistance and cardiovascular diseases. GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells. We hypothesized that GATA2 activity is controlled by insulin during adipogenesis, linking metabolic homeostasis and inflammation.
Menghini, R., Marchetti, V., Cardellini, M., Hribal, M., Mauriello, A., Lauro, D., et al. (2005). Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. CIRCULATION, 111(15), 1946-1953 [10.1161/01.CIR.0000161814.02942.B2].
Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis
MENGHINI, ROSSELLA;CARDELLINI, MARINA;MAURIELLO, ALESSANDRO;LAURO, DAVIDE;SBRACCIA, PAOLO;LAURO, RENATO;FEDERICI, MASSIMO
2005-04-19
Abstract
Obesity-related inflammation is emerging as a major cause of insulin resistance and cardiovascular diseases. GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells. We hypothesized that GATA2 activity is controlled by insulin during adipogenesis, linking metabolic homeostasis and inflammation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.