Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive tumor microenvironment (TME) through promoting angiogenesis, metabolic reprogramming, extracellular matrix remodeling, epithelial-mesenchymal transition (EMT), p53 inactivation, and immune evasion. Vascular normalization, a strategy aimed at restoring the structure and function of tumor blood vessels, has been shown to improve oxygen delivery and reverse hypoxia-induced signaling pathways, thus alleviates hypoxia and potentiates cancer immunotherapy. In this review, we discuss the mechanisms of tumor tissue hypoxia and its impacts on immune cells and cancer immunotherapy, as well as the approaches to induce tumor vascular normalization. We also summarize the evidence supporting the use of vascular normalization in combination with cancer immunotherapy, and highlight the challenges and future directions of this overlooked important field. By targeting the fundamental problem of tumor hypoxia, vascular normalization proposes a promising strategy to enhance the efficacy of cancer immunotherapy and improve clinical outcomes for cancer patients.

Fan, P., Zhang, N., Candi, E., Agostini, M., Piacentini, M., Bernassola, F., et al. (2023). Alleviating hypoxia to improve cancer immunotherapy. ONCOGENE, 42(49), 3591-3604 [10.1038/s41388-023-02869-2].

Alleviating hypoxia to improve cancer immunotherapy

Peng Fan;Eleonora Candi;Massimiliano Agostini
Membro del Collaboration Group
;
Mauro Piacentini;Bernassola Francesca;Bove Pierluigi;Mauriello Alessandro;Novelli Giuseppe;Rovella Valentina;Scimeca Manuel;Sica Giuseppe;Tisone Giuseppe;
2023-10-26

Abstract

Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive tumor microenvironment (TME) through promoting angiogenesis, metabolic reprogramming, extracellular matrix remodeling, epithelial-mesenchymal transition (EMT), p53 inactivation, and immune evasion. Vascular normalization, a strategy aimed at restoring the structure and function of tumor blood vessels, has been shown to improve oxygen delivery and reverse hypoxia-induced signaling pathways, thus alleviates hypoxia and potentiates cancer immunotherapy. In this review, we discuss the mechanisms of tumor tissue hypoxia and its impacts on immune cells and cancer immunotherapy, as well as the approaches to induce tumor vascular normalization. We also summarize the evidence supporting the use of vascular normalization in combination with cancer immunotherapy, and highlight the challenges and future directions of this overlooked important field. By targeting the fundamental problem of tumor hypoxia, vascular normalization proposes a promising strategy to enhance the efficacy of cancer immunotherapy and improve clinical outcomes for cancer patients.
26-ott-2023
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore BIO/11
English
Fan, P., Zhang, N., Candi, E., Agostini, M., Piacentini, M., Bernassola, F., et al. (2023). Alleviating hypoxia to improve cancer immunotherapy. ONCOGENE, 42(49), 3591-3604 [10.1038/s41388-023-02869-2].
Fan, P; Zhang, N; Candi, E; Agostini, M; Piacentini, M; Bernassola, F; Bove, P; Mauriello, A; Novelli, G; Rovella, V; Scimeca, M; Sica, G; Sun, Q; Tisone, G; Wang, Y; Shi, Y; Huang, Y; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/358102
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