Whether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.
Filomeni, G. (2024). ‘NO-how’ enzymatic S-nitrosylation controls insulin pathophysiology. TRENDS IN ENDOCRINOLOGY AND METABOLISM [10.1016/j.tem.2024.02.010].
‘NO-how’ enzymatic S-nitrosylation controls insulin pathophysiology
Giuseppe Filomeni
2024-01-01
Abstract
Whether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.File in questo prodotto:
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