Whether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.

Filomeni, G. (2024). ‘NO-how’ enzymatic S-nitrosylation controls insulin pathophysiology. TRENDS IN ENDOCRINOLOGY AND METABOLISM [10.1016/j.tem.2024.02.010].

‘NO-how’ enzymatic S-nitrosylation controls insulin pathophysiology

Giuseppe Filomeni
2024-01-01

Abstract

Whether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.
2024
In corso di stampa
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Con Impact Factor ISI
nitric oxide; SNO-CoA; SCAN; biliverdin reductase; insulin receptor; heme-oxygenase 2
https://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(24)00039-0
Filomeni, G. (2024). ‘NO-how’ enzymatic S-nitrosylation controls insulin pathophysiology. TRENDS IN ENDOCRINOLOGY AND METABOLISM [10.1016/j.tem.2024.02.010].
Filomeni, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/357783
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